Bioinformatics Lab @ Wilmer Institute, Johns Hopkins University

Tissue-specific Gene Expression and Regulation (TiGER)

TiGER is a database developed by the Bioinformatics Lab at Wilmer Eye Institute of Johns Hopkins University. The database contains tissue-specific gene expression profiles or expressed sequence tag (EST) data, cis-regulatory module (CRM) data, and combinatorial gene regulation data. Learn more about the database.

To download the raw data files, click here. To search the database, use the following three views:

 Gene View

Enter a RefSeq gene (e.g., NM_052964), a UniGene (e.g., Hs.2182) or a gene symbol (e.g., myod1):


 Transcription Factor View

Enter a transcription factor name:
(e.g., crx)


 Tissue View

Select a tissue:




1. Liu, X., Yu, X., Zack, D.J., Zhu, H., Qian, J. (2008) TiGER: a database for tissue-specific gene expression and regulation. BMC Bioinformatics. 9:271.
2. Yu, X., Lin, J., Zack, D.J., Qian, J. (2007) Identification of tissue-specific cis-regulatory modules based on interactions between transcription factors. BMC Bioinformatics. 8:437.
3. Yu, X., Lin, J., Zack, D.J., Qian, J. (2006) Computational analysis of tissue-specific combinatorial gene regulation: predicting interaction between transcription factors in human tissues. Nucleic Acids Res. 34, 49254936.
4. Yu, X., Lin, J., Masuda, T., Esumi, N., Zack, D.J., Qian, J. (2006) Genome-wide prediction and characterization of interactions between transcription factors in Saccharomyces cerevisiae. Nucleic Acids Res. 34, 917927.

Contact:  Jiang Qian (