SYK is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
BLNKSYK->MAP4K1->LCP2
SHC1SYK->MAP4K1->LCP2
SHC1SYK->PRKCA->ITGB4
SHC1SYK->PRKCA->PLCG1
SHC1SYK->PRKCA->PTPN12
SHC1SYK->PRKCA->PTPN6
SHC1SYK->PTK2B->ESR1
SHC1SYK->PRKCA->EGFR->CBL
SHC1SYK->PRKCA->EGFR->CRK
SHC1SYK->PRKCA->EGFR->GAB1
SHC1SYK->PRKCA->EGFR->GRB2
SHC1SYK->PRKCA->EGFR->PLCG1
SHC1SYK->PRKCA->EGFR->RASA1
SHC1SYK->PRKCA->EGFR->STAT5B
SHC1SYK->PRKCA->INSR->CBL
SHC1SYK->PRKCA->INSR->DOK1
SHC1SYK->PRKCA->INSR->GAB1
SHC1SYK->PRKCA->INSR->PIK3R1
SH3BP2SYK->CBL
SH3BP2SYK->PLCG1
CBLSYK->PRKCA->CD5
CBLSYK->PRKCA->KIT
CBLSYK->PRKCA->PLCG1
CBLSYK->PRKCA->PTPN6
CBLSYK->PRKCA->SH3BP2
CBLSYK->PRKCA->EGFR->CRK
CBLSYK->PRKCA->EGFR->GRB2
CBLSYK->PRKCA->EGFR->PLCG1
CBLSYK->PRKCA->EGFR->STAT5B
CBLSYK->PRKCA->EGFR->VAV2
CBLSYK->PRKCA->INSR->PIK3R1
CBLSYK->PRKCA->INSR->SHC1
LATSYK->MAP4K1->LCP2
PTPN6SYK->PRKCA->CD5
PTPN6SYK->PRKCA->KIT
PTPN6SYK->PRKCA->MYH9
PTPN6SYK->PTK2B->ESR1
PTPN6SYK->PRKCA->EGFR->CBL
PTPN6SYK->PRKCA->EGFR->GRB2
PTPN6SYK->PRKCA->EGFR->STAT5B
PTPN6SYK->PRKCA->INSR->CBL
PTPN6SYK->PRKCA->INSR->DOK1
PTPN6SYK->PRKCA->INSR->PIK3R1
PTPN6SYK->PRKCA->INSR->SHC1
SRCSYK->PRKCA->ADRBK1->PDGFRB->PTPN11
SRCSYK->PRKCA->ADRBK1->PDGFRB->FYN->CAV1
SRCSYK->PRKCA->ADRBK1->PDGFRB->FYN->CBL
SRCSYK->PRKCA->ADRBK1->PDGFRB->FYN->CTNNB1
SRCSYK->PRKCA->ADRBK1->PDGFRB->FYN->FYB
SRCSYK->PRKCA->ADRBK1->PDGFRB->FYN->GRB10
SRCSYK->PRKCA->ADRBK1->PDGFRB->FYN->MAP2
SRCSYK->PRKCA->ADRBK1->PDGFRB->FYN->NMT1
SRCSYK->PRKCA->ADRBK1->PDGFRB->FYN->SHC1
SRCSYK->PRKCA->ADRBK1->PDGFRB->FYN->SKAP1
BTKSYK->PRKCA->KIT
BTKSYK->PRKCA->PLCG1
BTKSYK->PRKCA->PRKD1
BTKSYK->PRKCA->RPS6KB2
GAB2SYK->SHC1


The sequence of SYK

Amino acids in red are phosphorylation sites determined by MS/MS

MASSGMADSA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG 50
FALSVAHGRK AHHYTIEREL NGTYAIAGGR THASPADLCH YHSQESDGLV 100
CLLKKPFNRP QGVQPKTGPF EDLKENLIRE YVKQTWNLQG QALEQAIISQ 150
KPQLEKLIAT TAHEKMPWFH GKISREESEQ IVLIGSKTNG KFLIRARDNN 200
GSYALCLLHE GKVLHYRIDK DKTGKLSIPE GKKFDTLWQL VEHYSYKADG 250
LLRVLTVPCQ KIGTQGNVNF GGRPQLPGSH PATWSAGGII SRIKSYSFPK 300
PGHRKSSPAQ GNRQESTVSF NPYEPELAPW AADKGPQREA LPMDTEVYES 350
PYADPEEIRP KEVYLDRKLL TLEDKELGSG NFGTVKKGYY QMKKVVKTVA 400
VKILKNEAND PALKDELLAE ANVMQQLDNP YIVRMIGICE AESWMLVMEM 450
AELGPLNKYL QQNRHVKDKN IIELVHQVSM GMKYLEESNF VHRDLAARNV 500
LLVTQHYAKI SDFGLSKALR ADENYYKAQT HGKWPVKWYA PECINYYKFS 550
SKSDVWSFGV LMWEAFSYGQ KPYRGMKGSE VTAMLEKGER MGCPAGCPRE 600
MYDLMNLCWT YDVENRPGFA AVELRLRNYY YDVVN

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