SRC is a predicted scaffold protein, which is related to the following pathway(s).

SYK->PRKCA->ADRBK1->PDGFRB->PTPN11
SYK->PRKCA->ADRBK1->PDGFRB->FYN->CAV1
SYK->PRKCA->ADRBK1->PDGFRB->FYN->CBL
SYK->PRKCA->ADRBK1->PDGFRB->FYN->CTNNB1
SYK->PRKCA->ADRBK1->PDGFRB->FYN->FYB
SYK->PRKCA->ADRBK1->PDGFRB->FYN->GRB10
SYK->PRKCA->ADRBK1->PDGFRB->FYN->MAP2
SYK->PRKCA->ADRBK1->PDGFRB->FYN->NMT1
SYK->PRKCA->ADRBK1->PDGFRB->FYN->SHC1
SYK->PRKCA->ADRBK1->PDGFRB->FYN->SKAP1


SRC is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
INPPL1SRC->BCAR1
INPPL1SRC->CBL
INPPL1SRC->SHC1
INPPL1SRC->ABL1->CBL
INPPL1SRC->EGFR->CBL
GRB10SRC->ABL1->BCR
GRB10SRC->RAF1->MAP2K1->MAPK1->EGFR
PECAM1CSK->SRC->CTNNB1
PECAM1CSK->SRC->ITGB3
PECAM1CSK->SRC->PIK3R1
PECAM1CSK->SRC->PTPN6
PTPN18CSK->SRC->ABL1->PSTPIP1
PTPN1SRC->BCAR1
PTPN1SRC->CAV1
PTPN1SRC->CDH2
PTPN1SRC->CTNNB1
PTPN1SRC->ESR1
PTPN1SRC->IGF1R
PTPN1SRC->NFKBIA
PTPN1SRC->STAT5A
PTPN1SRC->STAT5B
PTPN1SRC->EGFR->GRB2
PTPN1SRC->EGFR->STAT5B
FGRCSK->SRC->CBL
FGRCSK->SRC->PTK2
FGRCSK->SRC->SNCA
PRKCZSRC->RAF1->MAP2K1->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->GSK3B->RELA
PRKCZSRC->RAF1->MAP2K1->MAPK1->CASP9
PRKCZSRC->RAF1->MAP2K1->MAPK1->MBP
PRKCZSRC->RAF1->MAP2K1->MAPK1->RELA
PRKCZSRC->RAF1->MAP2K1->MAPK3->CASP9
PRKCZSRC->RAF1->MAP2K1->MAPK3->IRS1
PRKCZSRC->RAF1->MAP2K1->MAPK3->MBP
PRKCZSRC->RAF1->MAP2K1->MAPK1->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->MAPK1->GSK3B->RELA
PRKCZSRC->RAF1->MAP2K1->MAPK3->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->MAPK3->GSK3B->RELA
METSRC->EGFR->CBL
METSRC->EGFR->GAB1
METSRC->EGFR->GRB2
METSRC->EGFR->HGS
METSRC->EGFR->PLCG1
DAB2CSK->SRC->ITGB3
DAB2CSK->SRC->LRP1
PLD2CSK->SRC->CAV1
PLD2CSK->SRC->CAV2
PLD2CSK->SRC->EGFR->PLCG1
GJA1CSK->SRC->CAV1
PKD1SRC->PTK2->ACTN1
ARHGAP17SRC->ABL1->BTK
ARHGAP17SRC->ABL1->CRK
SHC1CSK->SRC->CBL
SHC1CSK->SRC->DAG1
SHC1CSK->SRC->ESR1
SHC1CSK->SRC->INPPL1
SHC1CSK->SRC->ITGB3
SHC1CSK->SRC->LRP1
SHC1CSK->SRC->PIK3R1
SHC1CSK->SRC->PLCG2
SHC1CSK->SRC->PLSCR1
SHC1CSK->SRC->PTK2
SHC1CSK->SRC->PTPN6
SHC1CSK->SRC->RAPGEF1
SHC1CSK->SRC->STAT5A
SHC1CSK->SRC->STAT5B
SHC1CSK->SRC->ABL1->BCR
SHC1CSK->SRC->ABL1->CBL
SHC1CSK->SRC->ABL1->CRKL
SHC1CSK->SRC->ABL1->PLSCR1
SHC1CSK->SRC->EGFR->CBL
SHC1CSK->SRC->EGFR->CRK
SHC1CSK->SRC->EGFR->GAB1
SHC1CSK->SRC->EGFR->GRB2
SHC1CSK->SRC->EGFR->PLCG1
SHC1CSK->SRC->EGFR->RASA1
SHC1CSK->SRC->EGFR->STAT5B
SHC1CSK->SRC->IGF1R->CRK
CD33SRC->PTPN6
LYNCSK->SRC->EGFR->CBL
LYNCSK->SRC->EGFR->MUC1
LYNCSK->SRC->EGFR->PLCG1
LYNCSK->SRC->EGFR->RASA1
LYNCSK->SRC->EGFR->RGS16
RGS16CSK->SRC->EGFR
PTPN11PDGFRA->SRC->BCAR1
PTPN11PDGFRA->SRC->BDKRB2
PTPN11PDGFRA->SRC->CAV1
PTPN11PDGFRA->SRC->CBL
PTPN11PDGFRA->SRC->CD33
PTPN11PDGFRA->SRC->IGF1R
PTPN11PDGFRA->SRC->KIT
PTPN11PDGFRA->SRC->MPZL1
PTPN11PDGFRA->SRC->PIK3R1
PTPN11PDGFRA->SRC->PLCG2
PTPN11PDGFRA->SRC->PTPN6
PTPN11PDGFRA->SRC->PXN
PTPN11PDGFRA->SRC->SHC1
PTPN11PDGFRA->SRC->SPRY2
PTPN11PDGFRA->SRC->STAT1
PTPN11PDGFRA->SRC->STAT3
PTPN11PDGFRA->SRC->STAT5A
PTPN11PDGFRA->SRC->STAT5B
PTPN11PDGFRA->SRC->EGFR->CBL
PTPN11PDGFRA->SRC->EGFR->GAB1
PTPN11PDGFRA->SRC->EGFR->GRB2
PTPN11PDGFRA->SRC->EGFR->PLCG1
PTPN11PDGFRA->SRC->EGFR->STAT1
PTPN11PDGFRA->SRC->EGFR->STAT5B
PTPN11PDGFRA->SRC->PTK2->PXN
PLCG1PDGFRA->SRC->CBL
PLCG1PDGFRA->SRC->GNB2L1
PLCG1PDGFRA->SRC->KIT
PLCG1PDGFRA->SRC->PTK2
PLCG1PDGFRA->SRC->SHC1
PLCG1PDGFRA->SRC->ABL1->BCR
PLCG1PDGFRA->SRC->ABL1->CBL
PLCG1PDGFRA->SRC->ABL1->PRKD1
PLCG1PDGFRA->SRC->EGFR->CBL
PLCG1PDGFRA->SRC->EGFR->GAB1
PLCG1PDGFRA->SRC->EGFR->GRB2
PLCG1PDGFRA->SRC->EGFR->RASA1
PLCG1PDGFRA->SRC->ABL1->BTK->TEC
PLCG1PDGFRA->SRC->ABL1->BTK->WAS
PLCG1PDGFRA->SRC->ABL1->BTK->ITK->CD28
PLCG1PDGFRA->SRC->ABL1->BTK->ITK->TEC
DAB1CDK5->SRC->ITGB3
DAB1CDK5->SRC->LRP1
EGFRCSK->SRC->IGF1R->CRK
EGFRCSK->SRC->PTK2->PXN
CBLCSK->SRC->INPPL1
CBLCSK->SRC->KIT
CBLCSK->SRC->PIK3R1
CBLCSK->SRC->PTPN6
CBLCSK->SRC->PXN
CBLCSK->SRC->SHC1
CBLCSK->SRC->SPRY2
CBLCSK->SRC->STAT5A
CBLCSK->SRC->STAT5B
CBLPDGFRA->SRC->INPPL1
CBLPDGFRA->SRC->KIT
CBLPDGFRA->SRC->PIK3R1
CBLPDGFRA->SRC->PTPN6
CBLPDGFRA->SRC->PXN
CBLPDGFRA->SRC->SHC1
CBLPDGFRA->SRC->SPRY2
CBLPDGFRA->SRC->STAT5A
CBLPDGFRA->SRC->STAT5B
CBLCSK->SRC->ABL1->BCR
CBLCSK->SRC->ABL1->CRKL
CBLCSK->SRC->EGFR->CRK
CBLCSK->SRC->EGFR->GRB2
CBLCSK->SRC->EGFR->PLCG1
CBLCSK->SRC->EGFR->STAT5B
CBLCSK->SRC->EGFR->VAV2
CBLPDGFRA->SRC->ABL1->BCR
CBLPDGFRA->SRC->ABL1->CRK
CBLPDGFRA->SRC->ABL1->CRKL
CBLPDGFRA->SRC->EGFR->CRK
CBLPDGFRA->SRC->EGFR->GRB2
CBLPDGFRA->SRC->EGFR->PLCG1
CBLPDGFRA->SRC->EGFR->STAT5B
CBLPDGFRA->SRC->EGFR->VAV2
CBLCSK->SRC->ABL1->BTK->ITK
CBLPDGFRA->SRC->ABL1->BTK->ITK
DOK1CSK->SRC->GRB10
DOK1CSK->SRC->ITGB3
DOK1CSK->SRC->KIT
DOK1CSK->SRC->PIK3R1
DOK1CSK->SRC->PTPN6
DOK1CSK->SRC->SHC1
DOK1CSK->SRC->ABL1->CRKL
FASSRC->EGFR->CALM1
GRB2PDGFRA->SRC->ABL1->BCR
GRB2PDGFRA->SRC->ABL1->CBL
GRB2PDGFRA->SRC->ABL1->CRK
GRB2PDGFRA->SRC->ABL1->CRKL
GRB2PDGFRA->SRC->ABL1->MUC1
GRB2PDGFRA->SRC->ABL1->WASF2
GRB2PDGFRA->SRC->EGFR->CBL
GRB2PDGFRA->SRC->EGFR->CRK
GRB2PDGFRA->SRC->EGFR->GAB1
GRB2PDGFRA->SRC->EGFR->MUC1
GRB2PDGFRA->SRC->EGFR->PLCG1
GRB2PDGFRA->SRC->EGFR->PTPN1
GRB2PDGFRA->SRC->EGFR->RASA1
GRB2PDGFRA->SRC->EGFR->VAV2
GRB2PDGFRA->SRC->PTK2->PXN
PTPN21SRC->BMX
PTK2CSK->SRC->BCAR1
PTK2CSK->SRC->BMX
PTK2CSK->SRC->GSN
PTK2CSK->SRC->ITGB3
PTK2CSK->SRC->PIK3R1
PTK2CSK->SRC->PXN
PTK2CSK->SRC->SHC1
PTK2CSK->SRC->STAT1
PTK2CSK->SRC->EGFR->CRK
PTK2CSK->SRC->EGFR->GRB2
PTK2CSK->SRC->EGFR->PLCG1
PTK2CSK->SRC->EGFR->STAT1
PTK2CSK->SRC->IGF1R->CRK
DNM1CDK5->SRC->CAV1
DNM1CDK5->SRC->CTTN
DNM1CDK5->SRC->GNB2L1
DNM1CDK5->SRC->PIK3R1
DNM1CDK5->SRC->SH3GL1
MUC1SRC->EGFR->GRB2
STAT5BPDGFRA->SRC->CBL
STAT5BPDGFRA->SRC->KIT
STAT5BPDGFRA->SRC->PTPN6
STAT5BPDGFRA->SRC->SHC1
STAT5BPDGFRA->SRC->STAT1
STAT5BPDGFRA->SRC->STAT3
STAT5BPDGFRA->SRC->STAT5A
STAT5BPDGFRA->SRC->EGFR->CBL
STAT5BPDGFRA->SRC->EGFR->CRK
STAT5BPDGFRA->SRC->EGFR->PTPN1
STAT5BPDGFRA->SRC->EGFR->STAT1
SYN1CDK5->SRC->PAK2
SYN1CDK5->SRC->PIK3R1
SYN1CDK5->SRC->SPTAN1
IGF1RCSK->SRC->ESR1
IGF1RCSK->SRC->GNB2L1
IGF1RCSK->SRC->GRB10
IGF1RCSK->SRC->PIK3R1
IGF1RCSK->SRC->PXN
IGF1RCSK->SRC->SHC1
IGF1RCSK->SRC->STAT3
IGF1RCSK->SRC->EGFR->CRK
IGF1RCSK->SRC->EGFR->PTPN1
IGF1RCSK->SRC->EGFR->RASA1
IGF1RCSK->SRC->PTK2->PXN
PRKD1SRC->EGFR->PLCG1
PRKD1SRC->ABL1->BTK->PLCG2
CAV1CSK->SRC->BMX
CAV1CSK->SRC->CAV2
CAV1CSK->SRC->CTNNB1
CAV1CSK->SRC->DAG1
CAV1CSK->SRC->ESR1
CAV1CSK->SRC->LRP1
CAV1CSK->SRC->PTPN6
CAV1PDGFRA->SRC->BMX
CAV1PDGFRA->SRC->CAV2
CAV1PDGFRA->SRC->CTNNB1
CAV1PDGFRA->SRC->DAG1
CAV1PDGFRA->SRC->ESR1
CAV1PDGFRA->SRC->LRP1
CAV1PDGFRA->SRC->PTPN6
CAV1CSK->SRC->EGFR->PTPN1
CAV1PDGFRA->SRC->EGFR->PTPN1
CAV1CSK->SRC->ABL1->BTK->BMX
CAV1PDGFRA->SRC->ABL1->BTK->BMX
SHBPDGFRA->SRC->PIK3R1
DAPP1SRC->PLCG2
STAP2SRC->STAT3
STAP2SRC->STAT5A
STAP2SRC->STAT5B
STAT5APDGFRA->SRC->BMX
STAT5APDGFRA->SRC->CBL
STAT5APDGFRA->SRC->ESR1
STAT5APDGFRA->SRC->KIT
STAT5APDGFRA->SRC->SHC1
STAT5APDGFRA->SRC->STAT1
STAT5APDGFRA->SRC->STAT3
STAT5APDGFRA->SRC->STAT5B
STAT5APDGFRA->SRC->EGFR->CBL
STAT5APDGFRA->SRC->EGFR->CRK
STAT5APDGFRA->SRC->EGFR->PTPN1
STAT5APDGFRA->SRC->EGFR->STAT1
STAT5APDGFRA->SRC->EGFR->STAT5B
PTPN6SRC->ABL1->BCR
PTPN6SRC->ABL1->CBL
PTPN6SRC->EGFR->CBL
PTPN6SRC->EGFR->GRB2
PTPN6SRC->EGFR->STAT5B
PTPN2CDK5->SRC->SHC1
PTPN2CDK5->SRC->STAT1
PTPN2CDK5->SRC->STAT3
PTPN2CDK5->SRC->STAT5A
PTPN2CDK5->SRC->STAT5B
PTPN2CDK5->SRC->EGFR->STAT1
PTPN2CDK5->SRC->EGFR->STAT5B
DOK4SRC->IGF1R->CRK
PDGFRBPDGFRA->SRC->ARAF
PDGFRBPDGFRA->SRC->CBL
PDGFRBPDGFRA->SRC->GRB10
PDGFRBPDGFRA->SRC->ITGB3
PDGFRBPDGFRA->SRC->PIK3R1
PDGFRBPDGFRA->SRC->PTK2
PDGFRBPDGFRA->SRC->RAF1
PDGFRBPDGFRA->SRC->SHC1
PDGFRBPDGFRA->SRC->STAT1
PDGFRBPDGFRA->SRC->STAT3
PDGFRBPDGFRA->SRC->STAT5A
PDGFRBPDGFRA->SRC->STAT5B
PDGFRBPDGFRA->SRC->EGFR->CBL
PDGFRBPDGFRA->SRC->EGFR->CRK
PDGFRBPDGFRA->SRC->EGFR->GAB1
PDGFRBPDGFRA->SRC->EGFR->GRB2
PDGFRBPDGFRA->SRC->EGFR->PLCG1
PDGFRBPDGFRA->SRC->EGFR->PTPN1
PDGFRBPDGFRA->SRC->EGFR->RASA1
PDGFRBPDGFRA->SRC->EGFR->STAT1
PDGFRBPDGFRA->SRC->EGFR->STAT5B
PDGFRBPDGFRA->SRC->EGFR->VAV2
CSKSRC->EGFR->CBL
CSKSRC->EGFR->RASA1
CSKSRC->EGFR->RGS16
CSKSRC->IGF1R->ADRB2
CSKSRC->PTK2->PXN
PXNCSK->SRC->BCAR1
PXNCSK->SRC->CBL
PXNCSK->SRC->GSN
PXNCSK->SRC->PIK3R1
PXNCSK->SRC->PTK2
PXNCSK->SRC->ABL1->BCR
PXNCSK->SRC->ABL1->CBL
PXNCSK->SRC->ABL1->CRKL
PXNCSK->SRC->EGFR->CBL
PXNCSK->SRC->EGFR->CRK
PXNCSK->SRC->EGFR->GRB2
PXNCSK->SRC->EGFR->RASA1
PXNCSK->SRC->IGF1R->CRK
INSRCSK->SRC->CAV1
INSRCSK->SRC->CBL
INSRCSK->SRC->GNB2L1
INSRCSK->SRC->GRB10
INSRCSK->SRC->PIK3R1
INSRCSK->SRC->PTK2
INSRCSK->SRC->PTPN6
INSRCSK->SRC->RAF1
INSRCSK->SRC->SHC1
INSRCSK->SRC->STAT5A
INSRCSK->SRC->STAT5B
INSRCSK->SRC->IGF1R->ADRB2
INSRCSK->SRC->IGF1R->CRK
GSNCSK->SRC->BCAR1
GSNCSK->SRC->PXN
GSNCSK->SRC->PTK2->PXN
CRKPDGFRA->SRC->BCAR1
CRKPDGFRA->SRC->CBL
CRKPDGFRA->SRC->IGF1R
CRKPDGFRA->SRC->KIT
CRKPDGFRA->SRC->PIK3R1
CRKPDGFRA->SRC->PLSCR1
CRKPDGFRA->SRC->PXN
CRKPDGFRA->SRC->RAPGEF1
CRKPDGFRA->SRC->SHC1
CRKPDGFRA->SRC->STAT5A
CRKPDGFRA->SRC->STAT5B
CRKPDGFRA->SRC->ABL1->CBL
CRKPDGFRA->SRC->ABL1->CRKL
CRKPDGFRA->SRC->ABL1->PLSCR1
CRKPDGFRA->SRC->EGFR->CBL
CRKPDGFRA->SRC->EGFR->GAB1
CRKPDGFRA->SRC->EGFR->GRB2
CRKPDGFRA->SRC->EGFR->STAT5B
CRKPDGFRA->SRC->PTK2->PXN
RASA1CSK->SRC->CAV2
RASA1CSK->SRC->GNB2L1
RASA1CSK->SRC->GRLF1
RASA1CSK->SRC->IGF1R
RASA1CSK->SRC->KIT
RASA1CSK->SRC->PIK3R1
RASA1CSK->SRC->PXN
RASA1CSK->SRC->SHC1
RASA1CSK->SRC->ABL1->BCR
RASA1CSK->SRC->EGFR->GRB2
RASA1CSK->SRC->EGFR->PLCG1
CTNND1SRC->EGFR->MUC1
SH3BP1SRC->ABL1->CRK
KITSRC->ABL1->BCR
KITSRC->ABL1->CBL
KITSRC->ABL1->CRK
KITSRC->ABL1->CRKL
KITSRC->ABL1->BTK->TEC
PIK3R1PDGFRA->SRC->ABL1->CBL
PIK3R1PDGFRA->SRC->ABL1->CRK
PIK3R1PDGFRA->SRC->ABL1->CRKL
PIK3R1PDGFRA->SRC->ABL1->NFKBIA
PIK3R1PDGFRA->SRC->EGFR->CBL
PIK3R1PDGFRA->SRC->EGFR->CRK
PIK3R1PDGFRA->SRC->EGFR->GAB1
PIK3R1PDGFRA->SRC->EGFR->GRB2
PIK3R1PDGFRA->SRC->EGFR->HGS
PIK3R1PDGFRA->SRC->EGFR->RASA1
PIK3R1PDGFRA->SRC->IGF1R->CRK
PIK3R1PDGFRA->SRC->PTK2->PXN
MAPK8IP3SRC->RAF1->MAP2K1
CDCP1SRC->EGFR
BCAR1SRC->ABL1->CRK
BCAR1SRC->ABL1->CRKL
BCAR1SRC->EGFR->CRK
BCAR1SRC->EGFR->GRB2
BCAR1SRC->EGFR->PTPN1
BCAR1SRC->PTK2->PXN
CAV2SRC->EGFR->RASA1
ITGB3PDGFRA->SRC->PDPK1
ITGB3PDGFRA->SRC->PTK2
ITGB3PDGFRA->SRC->SHC1
WASSRC->EGFR->GRB2
WASSRC->EGFR->PLCG1
DDR2SRC->SHC1
CEACAM1SRC->ANXA2
CEACAM1SRC->EGFR
CEACAM1SRC->PTPN6
CEACAM1SRC->PXN
CEACAM1SRC->SHC1
CBLCSRC->SPRY2
CBLCSRC->EGFR->CRK
CBLCSRC->EGFR->GRB2
DAG1CSK->SRC->CAV1
DAG1CSK->SRC->SHC1
RPS6KB2SRC->PDPK1
DDEF1SRC->PTK2->PXN
GAB2SRC->PIK3R1
GAB2SRC->PLCG2
GAB2SRC->PTPN6
GAB2SRC->SHC1
GAB2SRC->EGFR->GRB2
CDH5CSK->SRC->CTNNB1
CDH5CSK->SRC->SHC1
EVLSRC->ABL1->CRKL
SNURFSRC->ESR1



SRC is a known signal protein, which is involved in the following pathway(s)

Scaffold Protein(s)Related Pathway(s)PMID
CAV1GNAI1->HRAS->SRC8910575
CRKSRC->GAB119350053

Reference:Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases.

PMID:8910575

Reference:Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.

PMID:19350053


The sequence of SRC

Amino acids in red are phosphorylation sites determined by MS/MS

MGSNKSKPKD ASQRRRSLEP AENVHGAGGG AFPASQTPSK PASADGHRGP 50
SAAFAPAAAE PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE 100
TDLSFKKGER LQIVNNTEGD WWLAHSLSTG QTGYIPSNYV APSDSIQAEE 150
WYFGKITRRE SERLLLNAEN PRGTFLVRES ETTKGAYCLS VSDFDNAKGL 200
NVKHYKIRKL DSGGFYITSR TQFNSLQQLV AYYSKHADGL CHRLTTVCPT 250
SKPQTQGLAK DAWEIPRESL RLEVKLGQGC FGEVWMGTWN GTTRVAIKTL 300
KPGTMSPEAF LQEAQVMKKL RHEKLVQLYA VVSEEPIYIV TEYMSKGSLL 350
DFLKGETGKY LRLPQLVDMA AQIASGMAYV ERMNYVHRDL RAANILVGEN 400
LVCKVADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALYG RFTIKSDVWS 450
FGILLTELTT KGRVPYPGMV NREVLDQVER GYRMPCPPEC PESLHDLMCQ 500
CWRKEPEERP TFEYLQAFLE DYFTSTEPQY QPGENL

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