SHC1 is a predicted scaffold protein, which is related to the following pathway(s).

CSK->FYN->CBL
CSK->FYN->CD247
CSK->FYN->FCGR2A
CSK->FYN->PLCG2
CSK->LYN->EPOR
CSK->LYN->FCGR2A
CSK->LYN->PLCG2
CSK->LYN->STAT5A
CSK->SRC->CBL
CSK->SRC->DAG1
CSK->SRC->ESR1
CSK->SRC->INPPL1
CSK->SRC->ITGB3
CSK->SRC->LRP1
CSK->SRC->PIK3R1
CSK->SRC->PLCG2
CSK->SRC->PLSCR1
CSK->SRC->PTK2
CSK->SRC->PTPN6
CSK->SRC->RAPGEF1
CSK->SRC->STAT5A
CSK->SRC->STAT5B
MAPK1->EGFR->CBL
MAPK1->EGFR->CRK
MAPK1->EGFR->GAB1
MAPK1->EGFR->GRB2
MAPK1->EGFR->PLCG1
MAPK1->EGFR->RASA1
MAPK1->EGFR->STAT5B
MAPK1->LCK->CBL
MAPK1->LCK->ESR1
MAPK1->LCK->IL2RB
MAPK1->LCK->PLCG2
MAPK1->LCK->PTPN6
MAPK1->MAPKAPK2->ESR1
PDGFRB->FYN->CBL
PDGFRB->FYN->CD247
PDGFRB->FYN->FCGR2A
PDGFRB->FYN->PLCG2
PRKCD->MET->GAB1
SYK->MAP4K1->LCP2
SYK->PRKCA->ITGB4
SYK->PRKCA->PLCG1
SYK->PRKCA->PTPN12
SYK->PRKCA->PTPN6
SYK->PTK2B->ESR1
CSK->SRC->ABL1->BCR
CSK->SRC->ABL1->CBL
CSK->SRC->ABL1->CRKL
CSK->SRC->ABL1->PLSCR1
CSK->SRC->EGFR->CBL
CSK->SRC->EGFR->CRK
CSK->SRC->EGFR->GAB1
CSK->SRC->EGFR->GRB2
CSK->SRC->EGFR->PLCG1
CSK->SRC->EGFR->RASA1
CSK->SRC->EGFR->STAT5B
CSK->SRC->IGF1R->CRK
MAPK1->LCK->ZAP70->GAB2
MAPK1->LCK->ZAP70->LCP2
SYK->PRKCA->EGFR->CBL
SYK->PRKCA->EGFR->CRK
SYK->PRKCA->EGFR->GAB1
SYK->PRKCA->EGFR->GRB2
SYK->PRKCA->EGFR->PLCG1
SYK->PRKCA->EGFR->RASA1
SYK->PRKCA->EGFR->STAT5B
SYK->PRKCA->INSR->CBL
SYK->PRKCA->INSR->DOK1
SYK->PRKCA->INSR->GAB1
SYK->PRKCA->INSR->PIK3R1



SHC1 is a known scaffold protein, which is related to the following pathway(s).

GRB2->PTPN12

Reference:Temporal regulation of EGF signalling networks by the scaffold protein Shc1.

PMID:23846654


SHC1 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
INPPL1SRC->SHC1
PTPN11KDR->FLT4->SHC1
PTPN11MAPK3->LCK->SHC1
PTPN11PDGFRA->SRC->SHC1
PTPN11PDGFRB->FYN->SHC1
PTPN11PRKCA->INSR->SHC1
PLCG1LCK->ZAP70->SHC1
PLCG1PDGFRA->SRC->SHC1
PLCG1PDGFRB->FYN->SHC1
CBLCSK->FYN->SHC1
CBLCSK->SRC->SHC1
CBLLCK->ZAP70->SHC1
CBLPDGFRA->SRC->SHC1
CBLPDGFRB->FYN->SHC1
CBLSYK->PRKCA->INSR->SHC1
DOK1CSK->FYN->SHC1
DOK1CSK->SRC->SHC1
PTK2CSK->FYN->SHC1
PTK2CSK->SRC->SHC1
PTK2PDGFRB->FYN->SHC1
STAT5BPDGFRA->SRC->SHC1
PAG1CSK->FYN->SHC1
PAG1LCK->ZAP70->SHC1
IGF1RCSK->SRC->SHC1
PIK3R2PDGFRB->FYN->SHC1
CD247CSK->FYN->SHC1
CD247LCK->ZAP70->SHC1
STAT5AMAPK1->LCK->SHC1
STAT5AMAPK3->LCK->SHC1
STAT5APDGFRA->SRC->SHC1
PTPN6LCK->ZAP70->SHC1
PTPN6SYK->PRKCA->INSR->SHC1
PTPN2INSR->SHC1
PTPN2CDK5->SRC->SHC1
SRCSYK->PRKCA->ADRBK1->PDGFRB->FYN->SHC1
LCP2LCK->ZAP70->SHC1
PDGFRBPDGFRA->SRC->SHC1
INSRCSK->SRC->SHC1
CRKPDGFRA->SRC->SHC1
CRKPDGFRB->FYN->SHC1
RASA1CSK->SRC->SHC1
RASA1LCK->ZAP70->SHC1
FCGR3ALCK->ZAP70->SHC1
ITGB3PDGFRA->SRC->SHC1
DDR2SRC->SHC1
CEACAM1INSR->SHC1
CEACAM1SRC->SHC1
DAG1CSK->FYN->SHC1
DAG1CSK->SRC->SHC1
GAB2SRC->SHC1
GAB2SYK->SHC1
GAB2MAPK1->LCK->SHC1
GAB2MAPK3->LCK->SHC1
GAB2MAPK1->LCK->ZAP70->SHC1
GAB2MAPK3->LCK->ZAP70->SHC1
CD3ELCK->ZAP70->SHC1
CDH5CSK->SRC->SHC1


The sequence of SHC1

Amino acids in red are phosphorylation sites determined by MS/MS

MNLLPPKPKY NPLRNESLSS MEEGASGSTP PEELPSPPAS SLGPILPPLP 50
GDDSPTTLCS FFPRMSNLRL ANPAGGRPGS KGEPGRAADD GEGIVGAAMP 100
DSGPLPLLQD MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH 150
PNDKVMGPGV SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP 200
GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ 250
IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV 300
ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY 350
NDFPGKEPPL GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV 400
GGDPEVRKQM PPPPPCPGRE LFDDPSYVNV QNLDKARQAV GGAGPPNPAI 450
NGSAPRDLFD MKPFEDALRV PPPPQSVSMA EQLRGEPWFH GKLSRREAEA 500
LLQLNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG VVRTKDHRFE 550
SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL

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