SH3RF1 is a known scaffold protein, which is related to the following pathway(s).
| ARHGEF2 | -> | MAP3K11 | -> | MAP2K4 | -> | MAP2K7 | -> | MAPK8 |
Reference:POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.
PMID:12514131
The sequence of SH3RF1
Amino acids in red are phosphorylation sites determined by MS/MS
MDESALLDLL ECPVCLERLD ASAKVLPCQH TFCKRCLLGI VGSRNELRCP 50
ECRTLVGSGV EELPSNILLV RLLDGIKQRP WKPGPGGGSG TNCTNALRSQ 100
SSTVANCSSK DLQSSQGGQQ PRVQSWSPPV RGIPQLPCAK ALYNYEGKEP 150
GDLKFSKGDI IILRRQVDEN WYHGEVNGIH GFFPTNFVQI IKPLPQPPPQ 200
CKALYDFEVK DKEADKDCLP FAKDDVLTVI RRVDENWAEG MLADKIGIFP 250
ISYVEFNSAA KQLIEWDKPP VPGVDAGECS SAAAQSSTAP KHSDTKKNTK 300
KRHSFTSLTM ANKSSQASQN RHSMEISPPV LISSSNPTAA ARISELSGLS 350
CSAPSQVHIS TTGLIVTPPP SSPVTTGPSF TFPSDVPYQA ALGTLNPPLP 400
PPPLLAATVL ASTPPGATAA AAAAGMGPRP MAGSTDQIAH LRPQTRPSVY 450
VAIYPYTPRK EDELELRKGE MFLVFERCQD GWFKGTSMHT SKIGVFPGNY 500
VAPVTRAVTN ASQAKVPMST AGQTSRGVTM VSPSTAGGPA QKLQGNGVAG 550
SPSVVPAAVV SAAHIQTSPQ AKVLLHMTGQ MTVNQARNAV RTVAAHNQER 600
PTAAVTPIQV QNAAGLSPAS VGLSHHSLAS PQPAPLMPGS ATHTAAISIS 650
RASAPLACAA AAPLTSPSIT SASLEAEPSG RIVTVLPGLP TSPDSASSAC 700
GNSSATKPDK DSKKEKKGLL KLLSGASTKR KPRVSPPASP TLEVELGSAE 750
LPLQGAVGPE LPPGGGHGRA GSCPVDGDGP VTTAVAGAAL AQDAFHRKAS 800
SLDSAVPIAP PPRQACSSLG PVLNESRPVV CERHRVVVSY PPQSEAELEL 850
KEGDIVFVHK KREDGWFKGT LQRNGKTGLF PGSFVENI