PXN is a predicted scaffold protein, which is related to the following pathway(s).

CSK->FYN->CBL
CSK->FYN->TGFB1I1
CSK->SRC->BCAR1
CSK->SRC->CBL
CSK->SRC->GSN
CSK->SRC->PIK3R1
CSK->SRC->PTK2
CSK->SRC->ABL1->BCR
CSK->SRC->ABL1->CBL
CSK->SRC->ABL1->CRKL
CSK->SRC->EGFR->CBL
CSK->SRC->EGFR->CRK
CSK->SRC->EGFR->GRB2
CSK->SRC->EGFR->RASA1
CSK->SRC->IGF1R->CRK


PXN is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PTPN11PDGFRA->SRC->PXN
PTPN11PDGFRA->SRC->PTK2->PXN
EGFRCSK->SRC->PTK2->PXN
CBLCSK->SRC->PXN
CBLPDGFRA->SRC->PXN
GRB2PDGFRA->SRC->PTK2->PXN
PTK2CSK->SRC->PXN
IGF1RCSK->SRC->PXN
IGF1RCSK->SRC->PTK2->PXN
PTPRHPTK2->PXN
CSKSRC->PTK2->PXN
GSNCSK->SRC->PXN
GSNCSK->SRC->PTK2->PXN
CRKPDGFRA->SRC->PXN
CRKPDGFRA->SRC->PTK2->PXN
RASA1CSK->SRC->PXN
PIK3R1PDGFRA->SRC->PTK2->PXN
BCAR1SRC->PTK2->PXN
CEACAM1SRC->PXN
DDEF1SRC->PTK2->PXN


The sequence of PXN

Amino acids in red are phosphorylation sites determined by MS/MS

MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP 50
PPPSSEALNG TILDPLDQWQ PSGSRFIHQQ PQSSSPVYGS SAKTSSVSNP 100
QDSVGSPCSR VGEEEHVYSF PNKQKSAEPS PTVMSTSLGS NLSELDRLLL 150
ELNAVQHNPP GFPADEANSS PPLPGALSPL YGVPETNSPL GGKAGPLTKE 200
KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG EMSSPQRVTS 250
TQQQTRISAS SATRELDELM ASLSDFKFMA QGKTGSSSPP GGPPKPGSQL 300
DSMLGSLQSD LNKLGVATVA KGVCGACKKP IAGQVVTAMG KTWHPEHFVC 350
THCQEEIGSR NFFERDGQPY CEKDYHNLFS PRCYYCNGPI LDKVVTALDR 400
TWHPEHFFCA QCGAFFGPEG FHEKDGKAYC RKDYFDMFAP KCGGCARAIL 450
ENYISALNTL WHPECFVCRE CFTPFVNGSF FEHDGQPYCE VHYHERRGSL 500
CSGCQKPITG RCITAMAKKF HPEHFVCAFC LKQLNKGTFK EQNDKPYCQN 550
CFLKLFC

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