| INSR | -> | SHC1 | CDC2 | -> | EGFR | -> | STAT1 | CDC2 | -> | EGFR | -> | STAT5B | CDK5 | -> | SRC | -> | SHC1 | CDK5 | -> | SRC | -> | STAT1 | CDK5 | -> | SRC | -> | STAT3 | CDK5 | -> | SRC | -> | STAT5A | CDK5 | -> | SRC | -> | STAT5B | JAK3 | -> | JAK1 | -> | STAT1 | JAK3 | -> | JAK1 | -> | STAT3 | CDK5 | -> | SRC | -> | EGFR | -> | STAT1 | CDK5 | -> | SRC | -> | EGFR | -> | STAT5B |
The sequence of PTPN2
Amino acids in red are phosphorylation sites determined by MS/MS
MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD 50
VSPYDHSRVK LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM 100
VWQQKTKAVV MLNRIVEKES VKCAQYWPTD DQEMLFKETG FSVKLLSEDV 150
KSYYTVHLLQ LENINSGETR TISHFHYTTW PDFGVPESPA SFLNFLFKVR 200
ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD DINIKQVLLN 250
MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA 300
FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSESALR 350
KRIREDRKAT TAQKVQQMKQ RLNENERKRK RWLYWQPILT KMGFMSVILV 400
GAFVGWRLFF QQNAL