| KDR | -> | FLT4 | -> | SHC1 | MAPK3 | -> | EGFR | -> | CBL | MAPK3 | -> | EGFR | -> | GAB1 | MAPK3 | -> | EGFR | -> | GRB2 | MAPK3 | -> | EGFR | -> | PLCG1 | MAPK3 | -> | EGFR | -> | STAT1 | MAPK3 | -> | EGFR | -> | STAT5B | MAPK3 | -> | LCK | -> | CBL | MAPK3 | -> | LCK | -> | CD33 | MAPK3 | -> | LCK | -> | PLCG2 | MAPK3 | -> | LCK | -> | PTPN6 | MAPK3 | -> | LCK | -> | SHC1 | MAPK3 | -> | LCK | -> | SLAMF1 | MAPK3 | -> | LCK | -> | SOCS3 | PDGFRA | -> | SRC | -> | BCAR1 | PDGFRA | -> | SRC | -> | BDKRB2 | PDGFRA | -> | SRC | -> | CAV1 | PDGFRA | -> | SRC | -> | CBL | PDGFRA | -> | SRC | -> | CD33 | PDGFRA | -> | SRC | -> | IGF1R | PDGFRA | -> | SRC | -> | KIT | PDGFRA | -> | SRC | -> | MPZL1 | PDGFRA | -> | SRC | -> | PIK3R1 | PDGFRA | -> | SRC | -> | PLCG2 | PDGFRA | -> | SRC | -> | PTPN6 | PDGFRA | -> | SRC | -> | PXN | PDGFRA | -> | SRC | -> | SHC1 | PDGFRA | -> | SRC | -> | SPRY2 | PDGFRA | -> | SRC | -> | STAT1 | PDGFRA | -> | SRC | -> | STAT3 | PDGFRA | -> | SRC | -> | STAT5A | PDGFRA | -> | SRC | -> | STAT5B | PDGFRB | -> | FYN | -> | CAV1 | PDGFRB | -> | FYN | -> | CBL | PDGFRB | -> | FYN | -> | PLCG2 | PDGFRB | -> | FYN | -> | SHC1 | PDGFRB | -> | FYN | -> | SLAMF1 | PRKCA | -> | EGFR | -> | CBL | PRKCA | -> | EGFR | -> | GAB1 | PRKCA | -> | EGFR | -> | GRB2 | PRKCA | -> | EGFR | -> | PLCG1 | PRKCA | -> | EGFR | -> | STAT1 | PRKCA | -> | EGFR | -> | STAT5B | PRKCA | -> | INSR | -> | CBL | PRKCA | -> | INSR | -> | GAB1 | PRKCA | -> | INSR | -> | PIK3R1 | PRKCA | -> | INSR | -> | SHC1 | PDGFRA | -> | SRC | -> | EGFR | -> | CBL | PDGFRA | -> | SRC | -> | EGFR | -> | GAB1 | PDGFRA | -> | SRC | -> | EGFR | -> | GRB2 | PDGFRA | -> | SRC | -> | EGFR | -> | PLCG1 | PDGFRA | -> | SRC | -> | EGFR | -> | STAT1 | PDGFRA | -> | SRC | -> | EGFR | -> | STAT5B | PDGFRA | -> | SRC | -> | PTK2 | -> | PXN |
| Scaffold Protein(s) | Related Pathway(s) | SRC | SYK->PRKCA->ADRBK1->PDGFRB->PTPN11 |
|---|
The sequence of PTPN11
Amino acids in red are phosphorylation sites determined by MS/MS
MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA 50
VTHIKIQNTG DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY 100
PLNCADPTSE RWFHGHLSGK EAEKLLTEKG KHGSFLVRES QSHPGDFVLS 150
VRTGDDKGES NDGKSKVTHV MIRCQELKYD VGGGERFDSL TDLVEHYKKN 200
PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT DKVKQGFWEE 250
FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 300
VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS 350
RVIVMTTKEV ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE 400
LKLSKVGQGN TERTVWQYHF RTWPDHGVPS DPGGVLDFLE EVHHKQESIM 450
DAGPVVVHCS AGIGRTGTFI VIDILIDIIR EKGVDCDIDV PKTIQMVRSQ 500
RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH EYTNIKYSLA 550
DQTSGDQSPL PPCTPTPPCA EMREDSARVY ENVGLMQQQK SFR 600