PSEN1 is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PRKCZMAPK1->MAP2K1->GSK3B->PSEN1
PRKCZMAPK1->MAP2K1->MAPK3->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->MAPK1->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->MAPK3->GSK3B->PSEN1


The sequence of PSEN1

Amino acids in red are phosphorylation sites determined by MS/MS

MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DNRERQEHND RRSLGHPEPL 50
SNGRPQGNSR QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI 100
KSVSFYTRKD GQLIYTPFTE DTETVGQRAL HSILNAAIMI SVIVVMTILL 150
VVLYKYRCYK VIHAWLIISS LLLLFFFSFI YLGEVFKTYN VAVDYITVAL 200
LIWNFGVVGM ISIHWKGPLR LQQAYLIMIS ALMALVFIKY LPEWTAWLIL 250
AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE 300
GDPEAQRRVS KNSKYNAEST ERESQDTVAE NDDGGFSEEW EAQRDSHLGP 350
HRSTPESRAA VQELSSSILA GEDPEERGVK LGLGDFIFYS VLVGKASATA 400
SGDWNTTIAC FVAILIGLCL TLLLLAIFKK ALPALPISIT FGLVFYFATD 450
YLVQPFMDQL AFHQFYI

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