PLK1 is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PIN1PLK1->WEE1->CDC2->CDC25C
PIN1PLK1->WEE1->CDC2->CDC27
PIN1PLK1->WEE1->CDC2->PTPN1
PIN1PLK1->WEE1->CDC2->TOP2A
PIN1PLK1->WEE1->CDC2->CSNK2A1->JUN
PIN1PLK1->WEE1->CDC2->CSNK2A1->TOP2A
CDC25CPLK1->CHEK2->TP53
PKMYT1PLK1->CCNB1
PKMYT1PLK1->PIN1
MYT1PLK1->PIN1


The sequence of PLK1

Amino acids in red are phosphorylation sites determined by MS/MS

MSAAVTAGKL ARAPADPGKA GVPGVAAPGA PAAAPPAKEI PEVLVDPRSR 50
RRYVRGRFLG KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQREKMSM 100
EISIHRSLAH QHVVGFHGFF EDNDFVFVVL ELCRRRSLLE LHKRRKALTE 150
PEARYYLRQI VLGCQYLHRN RVIHRDLKLG NLFLNEDLEV KIGDFGLATK 200
VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI MYTLLVGKPP 250
FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPTINELL 300
NDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSNRKPL TVLNKGLENP 350
LPERPREKEE PVVRETGEVV DCHLSDMLQQ LHSVNASKPS ERGLVRQEEA 400
EDPACIPIFW VSKWVDYSDK YGLGYQLCDN SVGVLFNDST RLILYNDGDS 450
LQYIERDGTE SYLTVSSHPN SLMKKITLLK YFRNYMSEHL LKAGANITPR 500
EGDELARLPY LRTWFRTRSA IILHLSNGSV QINFFQDHTK LILCPLMAAV 550
TYIDEKRDFR TYRLSLLEEY GCCKELASRL RYARTMVDKL LSSRSASNRL 600
KAS

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