PAK1 is a predicted scaffold protein, which is related to the following pathway(s).

RAF1->MAP2K1->MAPK1->MBP
RAF1->MAP2K1->MAPK1->SMAD1
RAF1->MAP2K1->MAPK1->EGFR->GRB2
RAF1->MAP2K1->MAPK1->EGFR->HGS
RAF1->MAP2K1->MAPK1->EGFR->PLCG1


PAK1 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
EGFRMAP2K1->MAPK1->PAK1->ESR1
EGFRPAK1->MAP2K1->MAPK1->GAB1
EGFRPAK1->MAP2K1->MAPK1->GRB10
EGFRPAK1->MAP2K1->MAPK1->SOS1
EGFRPAK1->MAP2K1->MAPK1->STAT5A
RAF1MAP2K1->MAPK1->PAK1->BRAF
RAF1PAK1->MAP2K1->MAPK1->GRB10
RAF1PAK1->MAP2K1->MAPK1->MYC
RAF1MAPK1->PAK1->MAP2K1->MAPK3->GRB10
RAF1PAK1->MAP2K1->MAPK1->LCK->IL2RB
RAF1PAK1->MAP2K1->MAPK1->LCK->VAV1
RAF1MAPK1->PAK1->MAP2K1->MAPK3->LCK->IL2RB
RAF1MAPK1->PAK1->MAP2K1->MAPK3->LCK->VAV1
MAP2K1MAPK1->PAK1->BRAF
MAP2K1MAPK1->PAK1->FLNA
MAP2K1MAPK1->PAK1->RAF1


The sequence of PAK1

Amino acids in red are phosphorylation sites determined by MS/MS

MSNNGLDIQD KPPAPPMRNT STMIGAGSKD AGTLNHGSKP LPPNPEEKKK 50
KDRFYRSILP GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP 100
EQWARLLQTS NITKSEQKKN PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA 150
EDYNSSNALN VKAVSETPAV PPVSEDEDDD DDDATPPPVI APRPEHTKSV 200
YTRSVIEPLP VTPTRDVATS PISPTENNTT PPDALTRNTE KQKKKPKMSD 250
EEILEKLRSI VSVGDPKKKY TRFEKIGQGA SGTVYTAMDV ATGQEVAIKQ 300
MNLQQQPKKE LIINEILVMR ENKNPNIVNY LDSYLVGDEL WVVMEYLAGG 350
SLTDVVTETC MDEGQIAAVC RECLQALEFL HSNQVIHRDI KSDNILLGMD 400
GSVKLTDFGF CAQITPEQSK RSTMVGTPYW MAPEVVTRKA YGPKVDIWSL 450
GIMAIEMIEG EPPYLNENPL RALYLIATNG TPELQNPEKL SAIFRDFLNR 500
CLEMDVEKRG SAKELLQHQF LKIAKPLSSL TPLIAAAKEA TKNNH 550

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