MAP2K4 is a predicted scaffold protein, which is related to the following pathway(s).

MAP3K1->MAP2K7->MAPK10
MAP3K1->MAP2K7->MAPK8
MAP3K1->MAP2K7->MAPK9



MAP2K4 is a known scaffold protein, which is related to the following pathway(s).

MEKK1->JNK

Reference:Organization and regulation of mitogen-activated protein kinase signaling pathways.

PMID:10209154


MAP2K4 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
DUSP22MAP2K4->MAPK8
MAP3K2MAP3K5->MAP2K4->MAPK8->SFN
MAP3K2MAP3K5->MAP2K4->MAPK8->YWHAB
MAP3K2MAP3K5->MAP2K4->MAPK8->YWHAZ
MAP2K7MAP3K11->MAP2K4->MAPK8->MAPK8IP1
MAP2K7MAP3K11->MAP2K4->MAPK9->MAPK8IP1
MAP2K7MAP3K5->MAP2K4->MAPK8->MAPK8IP1
MAP2K7MAP3K5->MAP2K4->MAPK9->MAPK8IP1
MAPK14MAP2K4->MAPK8->ATF2
MAPK14MAP2K4->MAPK8->BCL2
MAPK8IP3MAP3K11->MAP2K4->MAPK10
MAPK8IP3MAP3K5->MAP2K4->MAPK10
MAPK8IP3MAP3K11->MAP2K4->MAPK8->MAPK8IP1
MAPK8IP3MAP3K11->MAP2K4->MAPK9->MAPK8IP1
MAPK8IP3MAP3K5->MAP2K4->MAPK8->MAPK8IP1
MAPK8IP3MAP3K5->MAP2K4->MAPK9->MAPK8IP1



MAP2K4 is also a known signal protein, which is involved in the following pathway(s)

Scaffold Protein(s)Related Pathway(s)PMID
SH3RF1ARHGEF2->MAP3K11->MAP2K4->MAP2K7->MAPK812514131

Reference:POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.

PMID:12514131


The sequence of MAP2K4

Amino acids in red are phosphorylation sites determined by MS/MS

MAAPSPSGGG GSGGGRGSGT PGPVGSPAPG HPAVSSMQGK RKALKLNFAN 50
PPFKSTARFT LNPNPTGVQN PHIERLRTHS IESSGKLKIS PEQHWDFTAE 100
DLKDLGEIGR GAYGSVNKMV HKPSGQIMAV KRIRSTVDEK EQKQLLMDLD 150
VVMRSSDCPY IVQFYGALFR EGDCWICMEL MSTSFDKFYK YVYSVLDDVI 200
PEEILGKITL ATVKALNHLK ENLKIIHRDI KPSNILLDRS GNIKLCDFGI 250
SGQLVDSIAK TRDAGCRPYM APERIDPSAS RQGYDVRSDV WSLGITLYEL 300
ATGRFPYPKW NSVFDQLTQV VKGDPPQLSN SEEREFSPSF INFVNLCLTK 350
DESKRLKYKE LLKHPFILMY EERAVEVACY VCKILDQMPA TPSSPMYVD 400

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