MAP2K1 is a predicted scaffold protein, which is related to the following pathway(s).

MAP2K1->MAPK1
MAPK1->MAP2K1->MAPK3
MAPK1->PAK1->BRAF
MAPK1->PAK1->FLNA
MAPK1->PAK1->RAF1


MAP2K1 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PAK1RAF1->MAP2K1->MAPK1->MBP
PAK1RAF1->MAP2K1->MAPK1->SMAD1
PAK1RAF1->MAP2K1->MAPK1->EGFR->GRB2
PAK1RAF1->MAP2K1->MAPK1->EGFR->HGS
PAK1RAF1->MAP2K1->MAPK1->EGFR->PLCG1
GRB10SRC->RAF1->MAP2K1->MAPK1->EGFR
PEBP4RAF1->MAP2K1
PRKCZMAPK1->MAP2K1->GSK3B->PSEN1
PRKCZMAPK1->MAP2K1->GSK3B->RELA
PRKCZMAPK1->MAP2K1->MAPK3->CASP9
PRKCZMAPK1->MAP2K1->MAPK3->IRS1
PRKCZMAPK1->MAP2K1->MAPK3->MBP
PRKCZMAPK1->MAP2K1->MAPK3->GSK3B->PSEN1
PRKCZMAPK1->MAP2K1->MAPK3->GSK3B->RELA
PRKCZSRC->RAF1->MAP2K1->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->GSK3B->RELA
PRKCZSRC->RAF1->MAP2K1->MAPK1->CASP9
PRKCZSRC->RAF1->MAP2K1->MAPK1->MBP
PRKCZSRC->RAF1->MAP2K1->MAPK1->RELA
PRKCZSRC->RAF1->MAP2K1->MAPK3->CASP9
PRKCZSRC->RAF1->MAP2K1->MAPK3->IRS1
PRKCZSRC->RAF1->MAP2K1->MAPK3->MBP
PRKCZSRC->RAF1->MAP2K1->MAPK1->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->MAPK1->GSK3B->RELA
PRKCZSRC->RAF1->MAP2K1->MAPK3->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->MAPK3->GSK3B->RELA
ELK1MAP2K1->MAPK1->FOS
ELK1MAP2K1->MAPK1->GRB10
ELK1MAPK1->MAP2K1->MAPK3->CEBPB
ELK1MAPK1->MAP2K1->MAPK3->FOS
ELK1MAPK1->MAP2K1->MAPK3->GRB10
PLK3MAP2K1->MAPK1
PLK3MAPK1->MAP2K1
EGFRMAP2K1->MAPK1->PAK1->ESR1
EGFRPAK1->MAP2K1->MAPK1->GAB1
EGFRPAK1->MAP2K1->MAPK1->GRB10
EGFRPAK1->MAP2K1->MAPK1->SOS1
EGFRPAK1->MAP2K1->MAPK1->STAT5A
RPS6KA4MAP2K1->MAPK1->FOS
RPS6KA4MAPK1->MAP2K1->MAPK3->FOS
MAP2K1IP1MAP2K1->MAPK1
MAP2K1IP1MAPK1->MAP2K1->MAPK3
MAPK14MAP2K1->MAPK1->DUSP1
MAPK14MAP2K1->MAPK1->DUSP16
MAPK14MAP2K1->MAPK1->DUSP6
MAPK14MAP2K1->MAPK1->MAPKAPK5
MAPK14MAP2K1->MAPK1->MBP
MAPK14MAP2K1->MAPK1->NFATC4
MAPK14MAP2K1->MAPK1->PLA2G4A
MAPK14MAP2K1->MAPK1->SMAD3
MAPK14MAP2K1->MAPK1->EGFR->GRB2
MAPK14MAP2K1->MAPK1->EGFR->STAT1
MAPK14MAP2K1->MAPK1->MAPKAPK2->CDC25B
MAPK14MAP2K1->MAPK1->MAPKAPK2->CREB1
MAPK14MAP2K1->MAPK1->MAPKAPK2->EEF2K
MAPK14MAP2K1->MAPK1->MAPKAPK2->ESR1
MAPK14MAPK1->MAP2K1->MAPK3->DUSP1
MAPK14MAPK1->MAP2K1->MAPK3->DUSP6
MAPK14MAPK1->MAP2K1->MAPK3->ELK1
MAPK14MAPK1->MAP2K1->MAPK3->ESR1
MAPK14MAPK1->MAP2K1->MAPK3->MBP
MAPK14MAPK1->MAP2K1->MAPK3->MKNK1
MAPK14MAPK1->MAP2K1->MAPK3->NFATC4
MAPK14MAPK1->MAP2K1->MAPK3->EGFR->GRB2
MAPK14MAPK1->MAP2K1->MAPK3->EGFR->STAT1
RAF1MAP2K1->MAPK1->PAK1->BRAF
RAF1MAPK1->MAP2K1->MAPK3->GRB10
RAF1PAK1->MAP2K1->MAPK1->GRB10
RAF1PAK1->MAP2K1->MAPK1->MYC
RAF1MAPK1->MAP2K1->MAPK3->LCK->IL2RB
RAF1MAPK1->MAP2K1->MAPK3->LCK->VAV1
RAF1MAPK1->PAK1->MAP2K1->MAPK3->GRB10
RAF1PAK1->MAP2K1->MAPK1->LCK->IL2RB
RAF1PAK1->MAP2K1->MAPK1->LCK->VAV1
RAF1MAPK1->PAK1->MAP2K1->MAPK3->LCK->IL2RB
RAF1MAPK1->PAK1->MAP2K1->MAPK3->LCK->VAV1
CASP9MAP2K1->MAPK1->CAPN2
CASP9MAPK1->MAP2K1->MAPK3->CAPN2
MAPK8IP3SRC->RAF1->MAP2K1
KSR2MAP3K8->MAP2K1->MAPK1
KSR2MAP3K8->MAP2K1->MAPK3
KSR2MAPK1->MAP2K1->MAPK3
KSR2RAF1->MAP2K1->MAPK1
KSR2RAF1->MAP2K1->MAPK3
PBPMAPK1->MAP2K1
PBPRAF1->MAP2K1->MAPK1
BRAFMAPK1->MAP2K1->MAPK3
BRAFRAF1->MAP2K1->MAPK1
BRAFRAF1->MAP2K1->MAPK3
PEBP1RAF1->MAP2K1->MAPK1
VAV1RAF1->MAP2K1->MAPK1->EGFR->CBL
VAV1RAF1->MAP2K1->MAPK1->EGFR->CRK
VAV1RAF1->MAP2K1->MAPK1->EGFR->GRB2
VAV1RAF1->MAP2K1->MAPK1->EGFR->PLCG1
VAV1RAF1->MAP2K1->MAPK1->LCK->CBL
VAV1RAF1->MAP2K1->MAPK1->LCK->PRKCQ
VAV1RAF1->MAP2K1->MAPK1->LCK->PTPN6
VAV1RAF1->MAP2K1->MAPK1->LCK->ZAP70->LCP2
RPS6KA2MAPK1->MAP2K1->MAPK3


The sequence of MAP2K1

Amino acids in red are phosphorylation sites determined by MS/MS

MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL 50
EAFLTQKQKV GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH 100
LEIKPAIRNQ IIRELQVLHE CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS 150
LDQVLKKAGR IPEQILGKVS IAVIKGLTYL REKHKIMHRD VKPSNILVNS 200
RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY SVQSDIWSMG 250
LSLVEMAVGR YPIPPPDAKE LELMFGCQVE GDAAETPPRP RTPGRPLSSY 300
GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA 350
DLKQLMVHAF IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA AGV 400

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