KIT is a predicted scaffold protein, which is related to the following pathway(s).

LYN->BTK->TEC
SRC->ABL1->BCR
SRC->ABL1->CBL
SRC->ABL1->CRK
SRC->ABL1->CRKL
SRC->ABL1->BTK->TEC


KIT is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PTPN11PDGFRA->SRC->KIT
PLCG1PDGFRA->SRC->KIT
CBLCSK->SRC->KIT
CBLPDGFRA->SRC->KIT
CBLSYK->PRKCA->KIT
DOK1CSK->SRC->KIT
STAT5BPDGFRA->SRC->KIT
STAT5APDGFRA->SRC->KIT
PTPN6SYK->PRKCA->KIT
BTKSYK->PRKCA->KIT
CRKPDGFRA->SRC->KIT
RASA1CSK->SRC->KIT


The sequence of KIT

Amino acids in red are phosphorylation sites determined by MS/MS

MRGARGAWDF LCVLLLLLRV QTGSSQPSVS PGEPSPPSIH PGKSDLIVRV 50
GDEIRLLCTD PGFVKWTFEI LDETNENKQN EWITEKAEAT NTGKYTCTNK 100
HGLSNSIYVF VRDPAKLFLV DRSLYGKEDN DTLVRCPLTD PEVTNYSLKG 150
CQGKPLPKDL RFIPDPKAGI MIKSVKRAYH RLCLHCSVDQ EGKSVLSEKF 200
ILKVRPAFKA VPVVSVSKAS YLLREGEEFT VTCTIKDVSS SVYSTWKREN 250
SQTKLQEKYN SWHHGDFNYE RQATLTISSA RVNDSGVFMC YANNTFGSAN 300
VTTTLEVVDK GFINIFPMIN TTVFVNDGEN VDLIVEYEAF PKPEHQQWIY 350
MNRTFTDKWE DYPKSENESN IRYVSELHLT RLKGTEGGTY TFLVSNSDVN 400
AAIAFNVYVN TKPEILTYDR LVNGMLQCVA AGFPEPTIDW YFCPGTEQRC 450
SASVLPVDVQ TLNSSGPPFG KLVVQSSIDS SAFKHNGTVE CKAYNDVGKT 500
SAYFNFAFKG NNKEQIHPHT LFTPLLIGFV IVAGMMCIIV MILTYKYLQK 550
PMYEVQWKVV EEINGNNYVY IDPTQLPYDH KWEFPRNRLS FGKTLGAGAF 600
GKVVEATAYG LIKSDAAMTV AVKMLKPSAH LTEREALMSE LKVLSYLGNH 650
MNIVNLLGAC TIGGPTLVIT EYCCYGDLLN FLRRKRDSFI CSKQEDHAEA 700
ALYKNLLHSK ESSCSDSTNE YMDMKPGVSY VVPTKADKRR SVRIGSYIER 750
DVTPAIMEDD ELALDLEDLL SFSYQVAKGM AFLASKNCIH RDLAARNILL 800
THGRITKICD FGLARDIKND SNYVVKGNAR LPVKWMAPES IFNCVYTFES 850
DVWSYGIFLW ELFSLGSSPY PGMPVDSKFY KMIKEGFRML SPEHAPAEMY 900
DIMKTCWDAD PLKRPTFKQI VQLIEKQISE STNHIYSNLA NCSPNRQKPV 950
VDHSVRINSV GSTASSSQPL LVHDDV

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