JAK1 is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
CXCR4JAK3->JAK1->STAT1
CXCR4JAK3->JAK1->STAT3
PRMT5JAK3->JAK1->TYK2
STAT5BJAK3->JAK1->STAT1
STAT5BJAK3->JAK1->STAT3
STAT5AJAK3->JAK1->STAT1
STAT5AJAK3->JAK1->STAT3
PTPN6JAK3->JAK1->TYK2->IFNAR1
PTPN2JAK3->JAK1->STAT1
PTPN2JAK3->JAK1->STAT3
IL7RJAK3->JAK1->STAT3
SKB1JAK3->JAK1->TYK2
STAT2JAK1->TYK2->IFNAR1
STATIP1JAK1->STAT1
STATIP1JAK1->STAT3
STATIP1JAK1->TYK2
STAM2JAK3->JAK1->TYK2
PIK3R1JAK3->JAK1->TYK2->IFNAR1
IFNAR2JAK1->TYK2->GNB2L1
IFNAR2JAK1->TYK2->IFNAR1
IL2RBJAK3->JAK1->STAT1
IL2RBJAK3->JAK1->STAT3
PTPRCJAK3->JAK1->TYK2->IFNAR1
IL2RGJAK3->JAK1->STAT1


The sequence of JAK1

Amino acids in red are phosphorylation sites determined by MS/MS

MQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVIF YLSDREPLRL 50
GSGEYTAEEL CIRAAQACRI SPLCHNLFAL YDENTKLWYA PNRTITVDDK 100
MSLRLHYRMR FYFTNWHGTN DNEQSVWRHS PKKQKNGYEK KKIPDATPLL 150
DASSLEYLFA QGQYDLVKCL APIRDPKTEQ DGHDIENECL GMAVLAISHY 200
AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI NNVFKDFLKE 250
FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 300
WFHSNDGGNV LYYEVMVTGN LGIQWRHKPN VVSVEKEKNK LKRKKLENKH 350
KKDEEKNKIR EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE 400
EALSFVSLVD GYFRLTADAH HYLCTDVAPP LIVHNIQNGC HGPICTEYAI 450
NKLRQEGSEE GMYVLRWSCT DFDNILMTVT CFEKSEQVQG AQKQFKNFQI 500
EVQKGRYSLH GSDRSFPSLG DLMSHLKKQI LRTDNISFML KRCCQPKPRE 550
ISNLLVATKK AQEWQPVYPM SQLSFDRILK KDLVQGEHLG RGTRTHIYSG 600
TLMDYKDDEG TSEEKKIKVI LKVLDPSHRD ISLAFFEAAS MMRQVSHKHI 650
VYLYGVCVRD VENIMVEEFV EGGPLDLFMH RKSDVLTTPW KFKVAKQLAS 700
ALSYLEDKDL VHGNVCTKNL LLAREGIDSE CGPFIKLSDP GIPITVLSRQ 750
ECIERIPWIA PECVEDSKNL SVAADKWSFG TTLWEICYNG EIPLKDKTLI 800
EKERFYESRC RPVTPSCKEL ADLMTRCMNY DPNQRPFFRA IMRDINKLEE 850
QNPDIVSEKK PATEVDPTHF EKRFLKRIRD LGEGHFGKVE LCRYDPEGDN 900
TGEQVAVKSL KPESGGNHIA DLKKEIEILR NLYHENIVKY KGICTEDGGN 950
GIKLIMEFLP SGSLKEYLPK NKNKINLKQQ LKYAVQICKG MDYLGSRQYV 1000
HRDLAARNVL VESEHQVKIG DFGLTKAIET DKEYYTVKDD RDSPVFWYAP 1050
ECLMQSKFYI ASDVWSFGVT LHELLTYCDS DSSPMALFLK MIGPTHGQMT 1100
VTRLVNTLKE GKRLPCPPNC PDEVYQLMRK CWEFQPSNRT SFQNLIEGFE 1150
ALLK

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