| Scaffold Protein(s) | Related Pathway(s) | PELI2 | IRAK4->IRAK1 | PELI1 | IRAK4->IRAK1 |
|---|
IRAK1 is a known signal protein, which is involved in the following pathway(s)
| Scaffold Protein(s) | Related Pathway(s) | PMID |
|---|---|---|
| PELI1 | IRAK1->TRAF6 | 16951688 |
| PELI3 | IRAK1->TNF6->TAB1->NIK | 12874243 |
Reference:Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.
PMID:16951688
Reference:Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein.
PMID:12874243
The sequence of IRAK1
Amino acids in red are phosphorylation sites determined by MS/MS
MAGGPGPGEP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV 50
RDQTELRLCE RSGQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT 100
AWHPPAPLPS PGTTAPRPSS IPAPAEAEAW SPRKLPSSAS TFLSPAFPGS 150
QTHSGPELGL VPSPASLWPP PPSPAPSSTK PGPESSVSLL QGARPSPFCW 200
PLCEISRGTH NFSEELKIGE GGFGCVYRAV MRNTVYAVKR LKENADLEWT 250
AVKQSFLTEV EQLSRFRHPN IVDFAGYCAQ NGFYCLVYGF LPNGSLEDRL 300
HCQTQACPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE 350
RLTPKLGDFG LARFSRFAGS SPSQSSMVAR TQTVRGTLAY LPEEYIKTGR 400
LAVDTDTFSF GVVVLETLAG QRAVKTHGAR TKYLVYERLE KLQAVVAGVP 450
GHLEAASCIP PSPQENSYVS STGRAHSGAA PWQPLAAPSG ASAQAAEQLQ 500
RGPNQPVESD ESLGGLSAAL RSWHLTPSCP LDPAPLREAG CPQGDTAGES 550
SWGSGPGSRP TAVEGLALGS SASSSSEPPQ IIINPARQKM VQKLALYEDG 600
ALDSLQLLSS SSLPGLGLEQ DRQGPEESDE FQS