| LYN | -> | EPOR | LYN | -> | PLCG2 | MAPK3 | -> | ETV6 | SRC | -> | PIK3R1 | SRC | -> | PLCG2 | SRC | -> | PTPN6 | SRC | -> | SHC1 | SYK | -> | SHC1 | MAPK1 | -> | EGFR | -> | GRB2 | MAPK1 | -> | LCK | -> | PLCG2 | MAPK1 | -> | LCK | -> | PTPN6 | MAPK1 | -> | LCK | -> | SHC1 | MAPK3 | -> | EGFR | -> | GRB2 | MAPK3 | -> | LCK | -> | PLCG2 | MAPK3 | -> | LCK | -> | PTPN6 | MAPK3 | -> | LCK | -> | SHC1 | SRC | -> | EGFR | -> | GRB2 | MAPK1 | -> | LCK | -> | ZAP70 | -> | SHC1 | MAPK3 | -> | LCK | -> | ZAP70 | -> | SHC1 |
GAB2 is a known scaffold protein, which is related to the following pathway(s).
| SHP2 | -> | P85 |
Reference:Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase.
PMID:11287610
| Scaffold Protein(s) | Related Pathway(s) | SHC1 | MAPK1->LCK->ZAP70->GAB2 | LAT | LCK->ZAP70->GAB2 | CD247 | LCK->ZAP70->GAB2 | PTPN6 | LCK->ZAP70->GAB2 |
|---|
The sequence of GAB2
Amino acids in red are phosphorylation sites determined by MS/MS
MSGGGDVVCT GWLRKSPPEK KLRRYAWKKR WFILRSGRMS GDPDVLEYYK 50
NDHSKKPLRI INLNFCEQVD AGLTFNKKEL QDSFVFDIKT SERTFYLVAE 100
TEEDMNKWVQ SICQICGFNQ AEESTDSLRN VSSAGHGPRS SPAELSSSSQ 150
HLLRERKSSA PSHSSQPTLF TFEPPVSNHM QPTLSTSAPQ EYLYLHQCIS 200
RRAENARSAS FSQGTRASFL MRSDTAVQKL AQGNGHCVNG ISGQVHGFYS 250
LPKPSRHNTE FRDSTYDLPR SLASHGHTKG SLTGSETDNE DVYTFKTPSN 300
TLCREFGDLL VDNMDVPATP LSAYQIPRTF TLDKNHNAMT VATPGDSAIA 350
PPPRPPKPSQ AETPRWGSPQ QRPPISENSR SVAATIPRRN TLPAMDNSRL 400
HRASSCETYE YPQRGGESAG RSAESMSDGV GSFLPGKMIV GRSDSTNSED 450
NYVPMNPGSS TLLAMERAGD NSQSVYIPMS PGAHHFDSLG YPSTTLPVHR 500
GPSRGSEIQP PPVNRNLKPD RKAKPTPLDL RNNTVIDELP FKSPITKSWS 550
RANHTFNSSS SQYCRPISTQ SITSTDSGDS EENYVPMQNP VSASPVPSGT 600
NSPAPKKSTG SVDYLALDFQ PSSPSPHRKP STSSVTSDEK VDYVQVDKEK 650
TQALQNTMQE WTDVRQSSEP SKGAKL