| MAPK1 | -> | EGFR | -> | CRK | MAPK1 | -> | EGFR | -> | GRB2 | MAPK1 | -> | EGFR | -> | PLCG1 | MAPK3 | -> | EGFR | -> | CRK | MAPK3 | -> | EGFR | -> | GRB2 | MAPK3 | -> | EGFR | -> | PLCG1 |
GAB1 is a known scaffold protein, which is related to the following pathway(s).
| GRB2 | -> | SOS |
Reference:Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops.
PMID:16687399
| Scaffold Protein(s) | Related Pathway(s) | MET | SRC->EGFR->GAB1 | SHC1 | MAPK1->EGFR->GAB1 | SHC1 | PRKCD->MET->GAB1 | SHC1 | CSK->SRC->EGFR->GAB1 | SHC1 | SYK->PRKCA->EGFR->GAB1 | SHC1 | SYK->PRKCA->INSR->GAB1 | PTPN11 | MAPK3->EGFR->GAB1 | PTPN11 | PRKCA->EGFR->GAB1 | PTPN11 | PRKCA->INSR->GAB1 | PTPN11 | PDGFRA->SRC->EGFR->GAB1 | PLCG1 | PDGFRA->SRC->EGFR->GAB1 | EGFR | PAK1->MAP2K1->MAPK1->GAB1 | GRB2 | PDGFRA->SRC->EGFR->GAB1 | PDGFRB | PDGFRA->SRC->EGFR->GAB1 | CRK | PDGFRA->SRC->EGFR->GAB1 | PIK3R1 | PDGFRA->SRC->EGFR->GAB1 |
|---|
GAB1 is also a known signal protein, which is involved in the following pathway(s)
| Scaffold Protein(s) | Related Pathway(s) | PMID |
|---|---|---|
| CRK | SRC->GAB1 | 19350053 |
Reference:Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.
PMID:19350053
The sequence of GAB1
Amino acids in red are phosphorylation sites determined by MS/MS
MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN 50
DHAKKPIRII DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS 100
EEEMNKWVRC ICDICGFNPT EEDPVKPPGS SLQAPADLPL AINTAPPSTQ 150
ADSSSATLPP PYQLINVPPH LETLGIQEDP QDYLLLINCQ SKKPEPTRTH 200
ADSAKSTSSE TDCNDNVPSH KNPASSQSKH GMNGFFQQQM IYDSPPSRAP 250
SASVDSSLYN LPRSYSHDVL PKVSPSSTEA DGELYVFNTP SGTSSVETQM 300
RHVSISYDIP PTPGNTYQIP RTFPEGTLGQ TSKLDTIPDI PPPRPPKPHP 350
AHDRSPVETC SIPRTASDTD SSYCIPTAGM SPSRSNTIST VDLNKLRKDA 400
SSQDCYDIPR AFPSDRSSSL EGFHNHFKVK NVLTVGSVSS EELDENYVPM 450
NPNSPPRQHS SSFTEPIQEA NYVPMTPGTF DFSSFGMQVP PPAHMGFRSS 500
PKTPPRRPVP VADCEPPPVD RNLKPDRKGQ SPKILRLKPH GLERTDSQTI 550
GDFATRRKVK PAPLEIKPLP EWEELQAPVR SPITRSFARD SSRFPMSPRP 600
DSVHSTTSSS DSHDSEENYV PMNPNLSSED PNLFGSNSLD GGSSPMIKPK 650
GDKQVEYLDL DLDSGKSTPP RKQKSSGSGS SVADERVDYV VVDQQKTLAL 700
KSTREAWTDG RQSTESETPA KSVK