EIF4E is a predicted scaffold protein, which is related to the following pathway(s).

FRAP1->RPS6KB1->EIF4B
RPS6KB1->FRAP1->EIF4EBP1


EIF4E is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
EIF4ERPS6KB1->FRAP1->EIF4EBP1



EIF4E is a known signal protein, which is involved in the following pathway(s)

Scaffold Protein(s)Related Pathway(s)PMID
EIF4G1EIF4A->EIF4E24505507
EIF4G2EIF4A->EIF4E9878069
EIF4G3EIF4A->EIF4E9878069

Reference:SEC14 and Spectrin Domains 1 (Sestd1), Dishevelled 2 (Dvl2) and Dapper Antagonist of Catenin-1 (Dact1) co-regulate the Wnt/Planar Cell Polarity (PCP) pathway during mammalian development.

PMID:24505507

Reference:Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.

PMID:9878069

Reference:Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.

PMID:9878069


The sequence of EIF4E

Amino acids in red are phosphorylation sites determined by MS/MS

MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN 50
DKSKTWQANL RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP 100
MWEDEKNKRG GRWLITLNKQ QRRSDLNRFW LETLLCLIGE SFDDYSDDVC 150
GAVVNVRAKG DKIAIWTTEC ENREAVTHIG RVYKERLGLP PKIVIGYQSH 200
ADTATKSGST TKNRFVV

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