EGFR is a predicted scaffold protein, which is related to the following pathway(s).

CSK->SRC->IGF1R->CRK
CSK->SRC->PTK2->PXN
MAP2K1->MAPK1->PAK1->ESR1
PAK1->MAP2K1->MAPK1->GAB1
PAK1->MAP2K1->MAPK1->GRB10
PAK1->MAP2K1->MAPK1->SOS1
PAK1->MAP2K1->MAPK1->STAT5A


EGFR is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
INPPL1SRC->EGFR->CBL
PAK1RAF1->MAP2K1->MAPK1->EGFR->GRB2
PAK1RAF1->MAP2K1->MAPK1->EGFR->HGS
PAK1RAF1->MAP2K1->MAPK1->EGFR->PLCG1
GRB10SRC->RAF1->MAP2K1->MAPK1->EGFR
PTPN1MAPK1->EGFR->GRB2
PTPN1MAPK1->EGFR->STAT5B
PTPN1SRC->EGFR->GRB2
PTPN1SRC->EGFR->STAT5B
PTPN1CSNK2A1->CDC2->EGFR->GRB2
PTPN1CSNK2A1->CDC2->EGFR->STAT5B
METSRC->EGFR->CBL
METSRC->EGFR->GAB1
METSRC->EGFR->GRB2
METSRC->EGFR->HGS
METSRC->EGFR->PLCG1
KRT8P9MAPK1->EGFR->ANXA1
KRT8P9MAPK3->EGFR->ANXA1
PLD2PRKCA->EGFR->PLCG1
PLD2CSK->SRC->EGFR->PLCG1
DUSP3MAPK1->EGFR->STAT1
DUSP3MAP2K2->MAPK3->EGFR->STAT1
SHC1MAPK1->EGFR->CBL
SHC1MAPK1->EGFR->CRK
SHC1MAPK1->EGFR->GAB1
SHC1MAPK1->EGFR->GRB2
SHC1MAPK1->EGFR->PLCG1
SHC1MAPK1->EGFR->RASA1
SHC1MAPK1->EGFR->STAT5B
SHC1CSK->SRC->EGFR->CBL
SHC1CSK->SRC->EGFR->CRK
SHC1CSK->SRC->EGFR->GAB1
SHC1CSK->SRC->EGFR->GRB2
SHC1CSK->SRC->EGFR->PLCG1
SHC1CSK->SRC->EGFR->RASA1
SHC1CSK->SRC->EGFR->STAT5B
SHC1SYK->PRKCA->EGFR->CBL
SHC1SYK->PRKCA->EGFR->CRK
SHC1SYK->PRKCA->EGFR->GAB1
SHC1SYK->PRKCA->EGFR->GRB2
SHC1SYK->PRKCA->EGFR->PLCG1
SHC1SYK->PRKCA->EGFR->RASA1
SHC1SYK->PRKCA->EGFR->STAT5B
LYNCSK->SRC->EGFR->CBL
LYNCSK->SRC->EGFR->MUC1
LYNCSK->SRC->EGFR->PLCG1
LYNCSK->SRC->EGFR->RASA1
LYNCSK->SRC->EGFR->RGS16
RGS16CSK->SRC->EGFR
PTPN11MAPK3->EGFR->CBL
PTPN11MAPK3->EGFR->GAB1
PTPN11MAPK3->EGFR->GRB2
PTPN11MAPK3->EGFR->PLCG1
PTPN11MAPK3->EGFR->STAT1
PTPN11MAPK3->EGFR->STAT5B
PTPN11PRKCA->EGFR->CBL
PTPN11PRKCA->EGFR->GAB1
PTPN11PRKCA->EGFR->GRB2
PTPN11PRKCA->EGFR->PLCG1
PTPN11PRKCA->EGFR->STAT1
PTPN11PRKCA->EGFR->STAT5B
PTPN11PDGFRA->SRC->EGFR->CBL
PTPN11PDGFRA->SRC->EGFR->GAB1
PTPN11PDGFRA->SRC->EGFR->GRB2
PTPN11PDGFRA->SRC->EGFR->PLCG1
PTPN11PDGFRA->SRC->EGFR->STAT1
PTPN11PDGFRA->SRC->EGFR->STAT5B
PLCG1PDGFRA->SRC->EGFR->CBL
PLCG1PDGFRA->SRC->EGFR->GAB1
PLCG1PDGFRA->SRC->EGFR->GRB2
PLCG1PDGFRA->SRC->EGFR->RASA1
CBLCSK->SRC->EGFR->CRK
CBLCSK->SRC->EGFR->GRB2
CBLCSK->SRC->EGFR->PLCG1
CBLCSK->SRC->EGFR->STAT5B
CBLCSK->SRC->EGFR->VAV2
CBLPDGFRA->SRC->EGFR->CRK
CBLPDGFRA->SRC->EGFR->GRB2
CBLPDGFRA->SRC->EGFR->PLCG1
CBLPDGFRA->SRC->EGFR->STAT5B
CBLPDGFRA->SRC->EGFR->VAV2
CBLSYK->PRKCA->EGFR->CRK
CBLSYK->PRKCA->EGFR->GRB2
CBLSYK->PRKCA->EGFR->PLCG1
CBLSYK->PRKCA->EGFR->STAT5B
CBLSYK->PRKCA->EGFR->VAV2
PLEC1CDC2->EGFR->GRB2
FASPRKCA->EGFR->CALM1
FASSRC->EGFR->CALM1
GRB2PDGFRA->SRC->EGFR->CBL
GRB2PDGFRA->SRC->EGFR->CRK
GRB2PDGFRA->SRC->EGFR->GAB1
GRB2PDGFRA->SRC->EGFR->MUC1
GRB2PDGFRA->SRC->EGFR->PLCG1
GRB2PDGFRA->SRC->EGFR->PTPN1
GRB2PDGFRA->SRC->EGFR->RASA1
GRB2PDGFRA->SRC->EGFR->VAV2
PTK2CSK->SRC->EGFR->CRK
PTK2CSK->SRC->EGFR->GRB2
PTK2CSK->SRC->EGFR->PLCG1
PTK2CSK->SRC->EGFR->STAT1
KRT18P19CDC2->EGFR->CBL
KRT18P19CDC2->EGFR->HGS
KRT18P19PRKCA->EGFR->CBL
KRT18P19PRKCA->EGFR->HGS
MUC1SRC->EGFR->GRB2
STAT5BMAPK1->EGFR->CBL
STAT5BMAPK1->EGFR->CRK
STAT5BMAPK1->EGFR->PTPN1
STAT5BMAPK1->EGFR->STAT1
STAT5BPDGFRA->SRC->EGFR->CBL
STAT5BPDGFRA->SRC->EGFR->CRK
STAT5BPDGFRA->SRC->EGFR->PTPN1
STAT5BPDGFRA->SRC->EGFR->STAT1
IGF1RCSK->SRC->EGFR->CRK
IGF1RCSK->SRC->EGFR->PTPN1
IGF1RCSK->SRC->EGFR->RASA1
PRKD1SRC->EGFR->PLCG1
CAV1MAPK1->EGFR->PTPN1
CAV1MAPK3->EGFR->PTPN1
CAV1CSK->SRC->EGFR->PTPN1
CAV1PDGFRA->SRC->EGFR->PTPN1
STAT5AMAPK1->EGFR->CBL
STAT5AMAPK1->EGFR->CRK
STAT5AMAPK1->EGFR->PTPN1
STAT5AMAPK1->EGFR->STAT1
STAT5AMAPK1->EGFR->STAT5B
STAT5AMAPK3->EGFR->CBL
STAT5AMAPK3->EGFR->CRK
STAT5AMAPK3->EGFR->PTPN1
STAT5AMAPK3->EGFR->STAT1
STAT5AMAPK3->EGFR->STAT5B
STAT5APDGFRA->SRC->EGFR->CBL
STAT5APDGFRA->SRC->EGFR->CRK
STAT5APDGFRA->SRC->EGFR->PTPN1
STAT5APDGFRA->SRC->EGFR->STAT1
STAT5APDGFRA->SRC->EGFR->STAT5B
PTPN6SRC->EGFR->CBL
PTPN6SRC->EGFR->GRB2
PTPN6SRC->EGFR->STAT5B
PTPN6SYK->PRKCA->EGFR->CBL
PTPN6SYK->PRKCA->EGFR->GRB2
PTPN6SYK->PRKCA->EGFR->STAT5B
PTPN2CDC2->EGFR->STAT1
PTPN2CDC2->EGFR->STAT5B
PTPN2CDK5->SRC->EGFR->STAT1
PTPN2CDK5->SRC->EGFR->STAT5B
MAPK14MAP2K1->MAPK1->EGFR->GRB2
MAPK14MAP2K1->MAPK1->EGFR->STAT1
MAPK14MAPK1->MAP2K1->MAPK3->EGFR->GRB2
MAPK14MAPK1->MAP2K1->MAPK3->EGFR->STAT1
PDGFRBPDGFRA->SRC->EGFR->CBL
PDGFRBPDGFRA->SRC->EGFR->CRK
PDGFRBPDGFRA->SRC->EGFR->GAB1
PDGFRBPDGFRA->SRC->EGFR->GRB2
PDGFRBPDGFRA->SRC->EGFR->PLCG1
PDGFRBPDGFRA->SRC->EGFR->PTPN1
PDGFRBPDGFRA->SRC->EGFR->RASA1
PDGFRBPDGFRA->SRC->EGFR->STAT1
PDGFRBPDGFRA->SRC->EGFR->STAT5B
PDGFRBPDGFRA->SRC->EGFR->VAV2
CSKSRC->EGFR->CBL
CSKSRC->EGFR->RASA1
CSKSRC->EGFR->RGS16
PXNCSK->SRC->EGFR->CBL
PXNCSK->SRC->EGFR->CRK
PXNCSK->SRC->EGFR->GRB2
PXNCSK->SRC->EGFR->RASA1
CRKPDGFRA->SRC->EGFR->CBL
CRKPDGFRA->SRC->EGFR->GAB1
CRKPDGFRA->SRC->EGFR->GRB2
CRKPDGFRA->SRC->EGFR->STAT5B
RASA1CSK->SRC->EGFR->GRB2
RASA1CSK->SRC->EGFR->PLCG1
CTNND1SRC->EGFR->MUC1
PIK3R1PDGFRA->SRC->EGFR->CBL
PIK3R1PDGFRA->SRC->EGFR->CRK
PIK3R1PDGFRA->SRC->EGFR->GAB1
PIK3R1PDGFRA->SRC->EGFR->GRB2
PIK3R1PDGFRA->SRC->EGFR->HGS
PIK3R1PDGFRA->SRC->EGFR->RASA1
CDCP1SRC->EGFR
BCAR1SRC->EGFR->CRK
BCAR1SRC->EGFR->GRB2
BCAR1SRC->EGFR->PTPN1
CAV2SRC->EGFR->RASA1
WASSRC->EGFR->GRB2
WASSRC->EGFR->PLCG1
CEACAM1SRC->EGFR
CBLCSRC->EGFR->CRK
CBLCSRC->EGFR->GRB2
GAB1MAPK1->EGFR->CRK
GAB1MAPK1->EGFR->GRB2
GAB1MAPK1->EGFR->PLCG1
GAB1MAPK3->EGFR->CRK
GAB1MAPK3->EGFR->GRB2
GAB1MAPK3->EGFR->PLCG1
GAB2MAPK1->EGFR->GRB2
GAB2MAPK3->EGFR->GRB2
GAB2SRC->EGFR->GRB2
VAV1RAF1->MAP2K1->MAPK1->EGFR->CBL
VAV1RAF1->MAP2K1->MAPK1->EGFR->CRK
VAV1RAF1->MAP2K1->MAPK1->EGFR->GRB2
VAV1RAF1->MAP2K1->MAPK1->EGFR->PLCG1



EGFR is a known signal protein, which is involved in the following pathway(s)

Scaffold Protein(s)Related Pathway(s)PMID
CD2APEGFR->CTTN12672817

Reference:A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton.

PMID:12672817


The sequence of EGFR

Amino acids in red are phosphorylation sites determined by MS/MS

MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS 50
LQRMFNNCEV VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP 100
LENLQIIRGN MYYENSYALA VLSNYDANKT GLKELPMRNL QEILHGAVRF 150
SNNPALCNVE SIQWRDIVSS DFLSNMSMDF QNHLGSCQKC DPSCPNGSCW 200
GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC TGPRESDCLV 250
CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300
VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS 350
INATNIKHFK NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE 400
ITGLS

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