CSK is a predicted scaffold protein, which is related to the following pathway(s).

SRC->EGFR->CBL
SRC->EGFR->RASA1
SRC->EGFR->RGS16
SRC->IGF1R->ADRB2
SRC->PTK2->PXN


CSK is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PECAM1CSK->FYN->CTNNB1
PECAM1CSK->SRC->CTNNB1
PECAM1CSK->SRC->ITGB3
PECAM1CSK->SRC->PIK3R1
PECAM1CSK->SRC->PTPN6
PTPN18CSK->SRC->ABL1->PSTPIP1
FGRCSK->SRC->CBL
FGRCSK->SRC->PTK2
FGRCSK->SRC->SNCA
DAB2CSK->SRC->ITGB3
DAB2CSK->SRC->LRP1
PLD2CSK->FYN->CAV1
PLD2CSK->SRC->CAV1
PLD2CSK->SRC->CAV2
PLD2CSK->SRC->EGFR->PLCG1
GJA1CSK->SRC->CAV1
SHC1CSK->FYN->CBL
SHC1CSK->FYN->CD247
SHC1CSK->FYN->FCGR2A
SHC1CSK->FYN->PLCG2
SHC1CSK->LYN->EPOR
SHC1CSK->LYN->FCGR2A
SHC1CSK->LYN->PLCG2
SHC1CSK->LYN->STAT5A
SHC1CSK->SRC->CBL
SHC1CSK->SRC->DAG1
SHC1CSK->SRC->ESR1
SHC1CSK->SRC->INPPL1
SHC1CSK->SRC->ITGB3
SHC1CSK->SRC->LRP1
SHC1CSK->SRC->PIK3R1
SHC1CSK->SRC->PLCG2
SHC1CSK->SRC->PLSCR1
SHC1CSK->SRC->PTK2
SHC1CSK->SRC->PTPN6
SHC1CSK->SRC->RAPGEF1
SHC1CSK->SRC->STAT5A
SHC1CSK->SRC->STAT5B
SHC1CSK->SRC->ABL1->BCR
SHC1CSK->SRC->ABL1->CBL
SHC1CSK->SRC->ABL1->CRKL
SHC1CSK->SRC->ABL1->PLSCR1
SHC1CSK->SRC->EGFR->CBL
SHC1CSK->SRC->EGFR->CRK
SHC1CSK->SRC->EGFR->GAB1
SHC1CSK->SRC->EGFR->GRB2
SHC1CSK->SRC->EGFR->PLCG1
SHC1CSK->SRC->EGFR->RASA1
SHC1CSK->SRC->EGFR->STAT5B
SHC1CSK->SRC->IGF1R->CRK
LYNCSK->SRC->EGFR->CBL
LYNCSK->SRC->EGFR->MUC1
LYNCSK->SRC->EGFR->PLCG1
LYNCSK->SRC->EGFR->RASA1
LYNCSK->SRC->EGFR->RGS16
RGS16CSK->SRC->EGFR
EGFRCSK->SRC->IGF1R->CRK
EGFRCSK->SRC->PTK2->PXN
CBLCSK->FYN->FYB
CBLCSK->FYN->ITCH
CBLCSK->FYN->SHC1
CBLCSK->LYN->CD19
CBLCSK->LYN->EPOR
CBLCSK->LYN->STAT5A
CBLCSK->SRC->INPPL1
CBLCSK->SRC->KIT
CBLCSK->SRC->PIK3R1
CBLCSK->SRC->PTPN6
CBLCSK->SRC->PXN
CBLCSK->SRC->SHC1
CBLCSK->SRC->SPRY2
CBLCSK->SRC->STAT5A
CBLCSK->SRC->STAT5B
CBLCSK->LYN->BTK->ITK
CBLCSK->SRC->ABL1->BCR
CBLCSK->SRC->ABL1->CRKL
CBLCSK->SRC->EGFR->CRK
CBLCSK->SRC->EGFR->GRB2
CBLCSK->SRC->EGFR->PLCG1
CBLCSK->SRC->EGFR->STAT5B
CBLCSK->SRC->EGFR->VAV2
CBLCSK->SRC->ABL1->BTK->ITK
DOK1CSK->FYN->GRB10
DOK1CSK->FYN->SHC1
DOK1CSK->SRC->GRB10
DOK1CSK->SRC->ITGB3
DOK1CSK->SRC->KIT
DOK1CSK->SRC->PIK3R1
DOK1CSK->SRC->PTPN6
DOK1CSK->SRC->SHC1
DOK1CSK->SRC->ABL1->CRKL
DOK3CSK->FYN
DOK3CSK->LYN
PTK2CSK->FYN->CD79B
PTK2CSK->FYN->SHC1
PTK2CSK->FYN->TGFB1I1
PTK2CSK->LYN->CD79B
PTK2CSK->SRC->BCAR1
PTK2CSK->SRC->BMX
PTK2CSK->SRC->GSN
PTK2CSK->SRC->ITGB3
PTK2CSK->SRC->PIK3R1
PTK2CSK->SRC->PXN
PTK2CSK->SRC->SHC1
PTK2CSK->SRC->STAT1
PTK2CSK->SRC->EGFR->CRK
PTK2CSK->SRC->EGFR->GRB2
PTK2CSK->SRC->EGFR->PLCG1
PTK2CSK->SRC->EGFR->STAT1
PTK2CSK->SRC->IGF1R->CRK
PAG1CSK->FYN->SHC1
IGF1RCSK->SRC->ESR1
IGF1RCSK->SRC->GNB2L1
IGF1RCSK->SRC->GRB10
IGF1RCSK->SRC->PIK3R1
IGF1RCSK->SRC->PXN
IGF1RCSK->SRC->SHC1
IGF1RCSK->SRC->STAT3
IGF1RCSK->SRC->EGFR->CRK
IGF1RCSK->SRC->EGFR->PTPN1
IGF1RCSK->SRC->EGFR->RASA1
IGF1RCSK->SRC->PTK2->PXN
CAV1CSK->FYN->CTNNB1
CAV1CSK->SRC->BMX
CAV1CSK->SRC->CAV2
CAV1CSK->SRC->CTNNB1
CAV1CSK->SRC->DAG1
CAV1CSK->SRC->ESR1
CAV1CSK->SRC->LRP1
CAV1CSK->SRC->PTPN6
CAV1CSK->SRC->EGFR->PTPN1
CAV1CSK->SRC->ABL1->BTK->BMX
CD247CSK->FYN->SHC1
PXNCSK->FYN->CBL
PXNCSK->FYN->TGFB1I1
PXNCSK->SRC->BCAR1
PXNCSK->SRC->CBL
PXNCSK->SRC->GSN
PXNCSK->SRC->PIK3R1
PXNCSK->SRC->PTK2
PXNCSK->SRC->ABL1->BCR
PXNCSK->SRC->ABL1->CBL
PXNCSK->SRC->ABL1->CRKL
PXNCSK->SRC->EGFR->CBL
PXNCSK->SRC->EGFR->CRK
PXNCSK->SRC->EGFR->GRB2
PXNCSK->SRC->EGFR->RASA1
PXNCSK->SRC->IGF1R->CRK
INSRCSK->SRC->CAV1
INSRCSK->SRC->CBL
INSRCSK->SRC->GNB2L1
INSRCSK->SRC->GRB10
INSRCSK->SRC->PIK3R1
INSRCSK->SRC->PTK2
INSRCSK->SRC->PTPN6
INSRCSK->SRC->RAF1
INSRCSK->SRC->SHC1
INSRCSK->SRC->STAT5A
INSRCSK->SRC->STAT5B
INSRCSK->SRC->IGF1R->ADRB2
INSRCSK->SRC->IGF1R->CRK
GSNCSK->SRC->BCAR1
GSNCSK->SRC->PXN
GSNCSK->SRC->PTK2->PXN
RASA1CSK->SRC->CAV2
RASA1CSK->SRC->GNB2L1
RASA1CSK->SRC->GRLF1
RASA1CSK->SRC->IGF1R
RASA1CSK->SRC->KIT
RASA1CSK->SRC->PIK3R1
RASA1CSK->SRC->PXN
RASA1CSK->SRC->SHC1
RASA1CSK->SRC->ABL1->BCR
RASA1CSK->SRC->EGFR->GRB2
RASA1CSK->SRC->EGFR->PLCG1
DAG1CSK->FYN->CAV1
DAG1CSK->FYN->SHC1
DAG1CSK->SRC->CAV1
DAG1CSK->SRC->SHC1
CDH5CSK->SRC->CTNNB1
CDH5CSK->SRC->SHC1


The sequence of CSK

Amino acids in red are phosphorylation sites determined by MS/MS

MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA 50
KNKVGREGII PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE 100
TGLFLVREST NYPGDYTLCV SCDGKVEHYR IMYHASKLSI DEEVYFENLM 150
QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ DEFYRSGWAL NMKELKLLQT 200
IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM TQLRHSNLVQ 250
LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV 350
KWTAPEALRE KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE 400
KGYKMDAPDG CPPAVYEVMK NCWHLDAAMR PSFLQLREQL EHIKTHELHL 450

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