CBL is a predicted scaffold protein, which is related to the following pathway(s).

CSK->FYN->FYB
CSK->FYN->ITCH
CSK->FYN->SHC1
CSK->LYN->CD19
CSK->LYN->EPOR
CSK->LYN->STAT5A
CSK->SRC->INPPL1
CSK->SRC->KIT
CSK->SRC->PIK3R1
CSK->SRC->PTPN6
CSK->SRC->PXN
CSK->SRC->SHC1
CSK->SRC->SPRY2
CSK->SRC->STAT5A
CSK->SRC->STAT5B
LCK->ZAP70->LCP2
LCK->ZAP70->SHC1
PDGFRA->SRC->INPPL1
PDGFRA->SRC->KIT
PDGFRA->SRC->PIK3R1
PDGFRA->SRC->PTPN6
PDGFRA->SRC->PXN
PDGFRA->SRC->SHC1
PDGFRA->SRC->SPRY2
PDGFRA->SRC->STAT5A
PDGFRA->SRC->STAT5B
PDGFRB->FYN->FYB
PDGFRB->FYN->ITCH
PDGFRB->FYN->SHC1
SYK->PRKCA->CD5
SYK->PRKCA->KIT
SYK->PRKCA->PLCG1
SYK->PRKCA->PTPN6
SYK->PRKCA->SH3BP2
CSK->LYN->BTK->ITK
CSK->SRC->ABL1->BCR
CSK->SRC->ABL1->CRKL
CSK->SRC->EGFR->CRK
CSK->SRC->EGFR->GRB2
CSK->SRC->EGFR->PLCG1
CSK->SRC->EGFR->STAT5B
CSK->SRC->EGFR->VAV2
PDGFRA->SRC->ABL1->BCR
PDGFRA->SRC->ABL1->CRK
PDGFRA->SRC->ABL1->CRKL
PDGFRA->SRC->EGFR->CRK
PDGFRA->SRC->EGFR->GRB2
PDGFRA->SRC->EGFR->PLCG1
PDGFRA->SRC->EGFR->STAT5B
PDGFRA->SRC->EGFR->VAV2
SYK->PRKCA->EGFR->CRK
SYK->PRKCA->EGFR->GRB2
SYK->PRKCA->EGFR->PLCG1
SYK->PRKCA->EGFR->STAT5B
SYK->PRKCA->EGFR->VAV2
SYK->PRKCA->INSR->PIK3R1
SYK->PRKCA->INSR->SHC1
CSK->SRC->ABL1->BTK->ITK
PDGFRA->SRC->ABL1->BTK->ITK



CBL is a known scaffold protein, which is related to the following pathway(s).

PIK3CG->TRANCE-R

Reference:A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.

PMID:11406619


CBL is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
INPPL1SRC->CBL
INPPL1SRC->ABL1->CBL
INPPL1SRC->EGFR->CBL
FGRCSK->SRC->CBL
METSRC->EGFR->CBL
SHC1CSK->FYN->CBL
SHC1CSK->SRC->CBL
SHC1MAPK1->EGFR->CBL
SHC1MAPK1->LCK->CBL
SHC1PDGFRB->FYN->CBL
SHC1CSK->SRC->ABL1->CBL
SHC1CSK->SRC->EGFR->CBL
SHC1SYK->PRKCA->EGFR->CBL
SHC1SYK->PRKCA->INSR->CBL
LYNCSK->SRC->EGFR->CBL
SH3BP2ABL1->CBL
SH3BP2FYN->CBL
SH3BP2LCK->CBL
SH3BP2SYK->CBL
PTPN11MAPK3->EGFR->CBL
PTPN11MAPK3->LCK->CBL
PTPN11PDGFRA->SRC->CBL
PTPN11PDGFRB->FYN->CBL
PTPN11PRKCA->EGFR->CBL
PTPN11PRKCA->INSR->CBL
PTPN11PDGFRA->SRC->EGFR->CBL
PLCG1PDGFRA->SRC->CBL
PLCG1PDGFRB->FYN->CBL
PLCG1PDGFRA->SRC->ABL1->CBL
PLCG1PDGFRA->SRC->EGFR->CBL
GRB2PDGFRA->SRC->ABL1->CBL
GRB2PDGFRA->SRC->EGFR->CBL
KRT18P19CDC2->EGFR->CBL
KRT18P19PRKCA->EGFR->CBL
STAT5BMAPK1->EGFR->CBL
STAT5BPDGFRA->SRC->CBL
STAT5BPDGFRA->SRC->EGFR->CBL
PIK3R2PDGFRB->FYN->CBL
STAT5AMAPK1->EGFR->CBL
STAT5AMAPK1->LCK->CBL
STAT5AMAPK3->EGFR->CBL
STAT5AMAPK3->LCK->CBL
STAT5APDGFRA->SRC->CBL
STAT5APDGFRA->SRC->EGFR->CBL
PTPN6SRC->ABL1->CBL
PTPN6SRC->EGFR->CBL
PTPN6SYK->PRKCA->EGFR->CBL
PTPN6SYK->PRKCA->INSR->CBL
SRCSYK->PRKCA->ADRBK1->PDGFRB->FYN->CBL
PDGFRBPDGFRA->SRC->CBL
PDGFRBPDGFRA->SRC->EGFR->CBL
CSKSRC->EGFR->CBL
PXNCSK->FYN->CBL
PXNCSK->SRC->CBL
PXNCSK->SRC->ABL1->CBL
PXNCSK->SRC->EGFR->CBL
INSRCSK->SRC->CBL
CRKPDGFRA->SRC->CBL
CRKPDGFRB->FYN->CBL
CRKPDGFRA->SRC->ABL1->CBL
CRKPDGFRA->SRC->EGFR->CBL
KITSRC->ABL1->CBL
PIK3R1PDGFRA->SRC->ABL1->CBL
PIK3R1PDGFRA->SRC->EGFR->CBL
KHDRBS1MAPK1->LCK->CBL
VAV1RAF1->MAP2K1->MAPK1->EGFR->CBL
VAV1RAF1->MAP2K1->MAPK1->LCK->CBL


The sequence of CBL

Amino acids in red are phosphorylation sites determined by MS/MS

MAGNVKKSSG AGGGSGSGGS GSGGLIGLMK DAFQPHHHHH HHLSPHPPGT 50
VDKKMVEKCW KLMDKVVRLC QNPKLALKNS PPYILDLLPD TYQHLRTILS 100
RYEGKMETLG ENEYFRVFME NLMKKTKQTI SLFKEGKERM YEENSQPRRN 150
LTKLSLIFSH MLAELKGIFP SGLFQGDTFR ITKADAAEFW RKAFGEKTIV 200
PWKSFRQALH EVHPISSGLE AMALKSTIDL TCNDYISVFE FDIFTRLFQP 250
WSSLLRNWNS LAVTHPGYMA FLTYDEVKAR LQKFIHKPGS YIFRLSCTRL 300
GQWAIGYVTA DGNILQTIPH NKPLFQALID GFREGFYLFP DGRNQNPDLT 350
GLCEPTPQDH IKVTQEQYEL YCEMGSTFQL CKICAENDKD VKIEPCGHLM 400
CTSCLTSWQE SEGQGCPFCR CEIKGTEPIV VDPFDPRGSG SLLRQGAEGA 450
PSPNYDDDDD ERADDTLFMM KELAGAKVER PPSPFSMAPQ ASLPPVPPRL 500
DLLPQRVCVP SSASALGTAS KAASGSLHKD KPLPVPPTLR DLPPPPPPDR 550
PYSVGAESRP QRRPLPCTPG DCPSRDKLPP VPSSRLGDSW LPRPIPKVPV 600
SAPSSSDPWT GRELTNRHSL PFSLPSQMEP RPDVPRLGST FSLDTSMSMN 650
SSPLVGPECD HPKIKPSSSA NAIYSLAARP LPVPKLPPGE QCEGEEDTEY 700
MTPSSRPLRP LDTSQSSRAC DCDQQIDSCT YEAMYNIQSQ APSITESSTF 750
GEGNLAAAHA NTGPEESENE DDGYDVPKPP VPAVLARRTL SDISNASSSF 800
GWLSLDGDPT TNVTEGSQVP ERPPKPFPRR INSERKAGSC QQGSGPAASA 850
ATASPQLSSE IENLMSQGYS YQDIQKALVI AQNNIEMAKN ILREFVSISS 900
PAHVAT

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