ZAP70 is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
SHC1MAPK1->LCK->ZAP70->GAB2
SHC1MAPK1->LCK->ZAP70->LCP2
SH3BP2LCK->ZAP70
PLCG1LCK->ZAP70->LCP2
PLCG1LCK->ZAP70->SHC1
CBLLCK->ZAP70->LCP2
CBLLCK->ZAP70->SHC1
LATLCK->ZAP70->GAB2
LATLCK->ZAP70->LCP2
PAG1LCK->ZAP70->LCP2
PAG1LCK->ZAP70->SHC1
CD247LCK->ZAP70->GAB2
CD247LCK->ZAP70->SH2B3
CD247LCK->ZAP70->SHC1
PTPN6LCK->ZAP70->GAB2
PTPN6LCK->ZAP70->LCP2
PTPN6LCK->ZAP70->SHC1
LCP2LCK->ZAP70->SHC1
RASA1LCK->ZAP70->SHC1
IFNAR1MAPK1->LCK->ZAP70
FCGR3ALCK->ZAP70->SHC1
GAB2MAPK1->LCK->ZAP70->SHC1
GAB2MAPK3->LCK->ZAP70->SHC1
CD3ELCK->ZAP70->SHC1
VAV1RAF1->MAP2K1->MAPK1->LCK->ZAP70->LCP2


The sequence of ZAP70

Amino acids in red are phosphorylation sites determined by MS/MS

MPDPAAHLPF FYGSISRAEA EEHLKLAGMA DGLFLLRQCL RSLGGYVLSL 50
VHDVRFHHFP IERQLNGTYA IAGGKAHCGP AELCEFYSRD PDGLPCNLRK 100
PCNRPSGLEP QPGVFDCLRD AMVRDYVRQT WKLEGEALEQ AIISQAPQVE 150
KLIATTAHER MPWYHSSLTR EEAERKLYSG AQTDGKFLLR PRKEQGTYAL 200
SLIYGKTVYH YLISQDKAGK YCIPEGTKFD TLWQLVEYLK LKADGLIYCL 250
KEACPNSSAS NASGAAAPTL PAHPSTLTHP QRRIDTLNSD GYTPEPARIT 300
SPDKPRPMPM DTSVYESPYS DPEELKDKKL FLKRDNLLIA DIELGCGNFG 350
SVRQGVYRMR KKQIDVAIKV LKQGTEKADT EEMMREAQIM HQLDNPYIVR 400
LIGVCQAEAL MLVMEMAGGG PLHKFLVGKR EEIPVSNVAE LLHQVSMGMK 450
YLEEKNFVHR DLAARNVLLV NRHYAKISDF GLSKALGADD SYYTARSAGK 500
WPLKWYAPEC INFRKFSSRS DVWSYGVTMW EALSYGQKPY KKMKGPEVMA 550
FIEQGKRMEC PPECPPELYA LMSDCWIYKW EDRPDFLTVE QRMRACYYSL 600
ASKVEGPPGS TQKAEAACA

Home