XRCC1 is a known scaffold protein, which is related to the following pathway(s).

POLB->LIG3

Reference: interaction between DNA polymerase beta and the XRCC1 protein.

PMID:Reconstitution of DNA base excision-repair with purified human proteins

XRCC1 is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
BRCA1CDK2->CDK7->CDC2->CSNK2A1->XRCC1


The sequence of XRCC1

Amino acids in red are phosphorylation sites determined by MS/MS

MPEIRLRHVV SCSSQDSTHC AENLLKADTY RKWRAAKAGE KTISVVLQLE 50
KEEQIHSVDI GNDGSAFVEV LVGSSAGGAG EQDYEVLLVT SSFMSPSESR 100
SGSNPNRVRM FGPDKLVRAA AEKRWDRVKI VCSQPYSKDS PFGLSFVRFH 150
SPPDKDEAEA PSQKVTVTKL GQFRVKEEDE SANSLRPGAL FFSRINKTSP 200
VTASDPAGPS YAAATLQASS AASSASPVSR AIGSTSKPQE SPKGKRKLDL 250
NQEEKKTPSK PPAQLSPSVP KRPKLPAPTR TPATAPVPAR AQGAVTGKPR 300
GEGTEPRRPR AGPEELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR 350
PDWTRDSTHL ICAFANTPKY SQVLGLGGRI VRKEWVLDCH RMRRRLPSQR 400
YLMAGPGSSS EEDEASHSGG SGDEAPKLPQ KQPQTKTKPT QAAGPSSPQK 450
PPTPEETKAA SPVLQEDIDI EGVQSEGQDN GAEDSGDTED ELRRVAEQKE 500
HRLPPGQEEN GEDPYAGSTD ENTDSEEHQE PPDLPVPELP DFFQGKHFFL 550
YGEFPGDERR KLIRYVTAFN GELEDYMSDR VQFVITAQEW DPSFEEALMD 600
NPSLAFVRPR WIYSCNEKQK LLPHQLYGVV PQA

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