| RAF1 | -> | MAP2K1 | -> | MAPK1 | -> | EGFR | -> | CBL | RAF1 | -> | MAP2K1 | -> | MAPK1 | -> | EGFR | -> | CRK | RAF1 | -> | MAP2K1 | -> | MAPK1 | -> | EGFR | -> | GRB2 | RAF1 | -> | MAP2K1 | -> | MAPK1 | -> | EGFR | -> | PLCG1 | RAF1 | -> | MAP2K1 | -> | MAPK1 | -> | LCK | -> | CBL | RAF1 | -> | MAP2K1 | -> | MAPK1 | -> | LCK | -> | PRKCQ | RAF1 | -> | MAP2K1 | -> | MAPK1 | -> | LCK | -> | PTPN6 | RAF1 | -> | MAP2K1 | -> | MAPK1 | -> | LCK | -> | ZAP70 | -> | LCP2 |
| Scaffold Protein(s) | Related Pathway(s) | SH3BP2 | LCK->VAV1 | RAF1 | MAP2K2->MAPK3->LCK->VAV1 | RAF1 | MAPK1->MAP2K1->MAPK3->LCK->VAV1 | RAF1 | PAK1->MAP2K1->MAPK1->LCK->VAV1 | RAF1 | MAPK1->PAK1->MAP2K1->MAPK3->LCK->VAV1 |
|---|
The sequence of VAV1
Amino acids in red are phosphorylation sites determined by MS/MS
MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL 50
LPHAINLREV NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF 100
DVQDFGKVIY TLSALSWTPI AQNRGIMPFP TEEESVGDED IYSGLSDQID 150
DTVEEDEDLY DCVENEEAEG DEIYEDLMRS EPVSMPPKMT EYDKRCCCLR 200
EIQQTEEKYT DTLGSIQQHF LKPLQRFLKP QDIEIIFINI EDLLRVHTHF 250
LKEMKEALGT PGAANLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVAAA 300
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQEA 350
MEKENLRLAL DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLAHY 400
GRPKIDGELK ITSVERRSKM DRYAFLLDKA LLICKRRGDS YDLKDFVNLH 450
SFQVRDDSSG DRDNKKWSHM FLLIEDQGAQ GYELFFKTRE LKKKWMEQFE 500
MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF YQGYRCHRCR 550
ASAHKECLGR VPPCGRHGQD FPGTMKKDKL HRRAQDKKRN ELGLPKMEVF 600
QEYYGLPPPP GAIGPFLRLN PGDIVELTKA EAEQNWWEGR NTSTNEIGWF 650
PCNRVKPYVH GPPQDLSVHL WYAGPMERAG AESILANRSD GTFLVRQRVK 700
DAAEFAISIK YNVEVKHIKI MTAEGLYRIT EKKAFRGLTE LVEFYQQNSL 750
KDCFKSLDTT LQFPFKEPEK RTISRPAVGS TKYFGTAKAR YDFCARDRSE 800
LSLKEGDIIK ILNKKGQQGW WRGEIYGRVG WFPANYVEED YSEYC 850