STAT5B is a predicted scaffold protein, which is related to the following pathway(s).

JAK3->JAK1->STAT1
JAK3->JAK1->STAT3
MAPK1->EGFR->CBL
MAPK1->EGFR->CRK
MAPK1->EGFR->PTPN1
MAPK1->EGFR->STAT1
PDGFRA->SRC->CBL
PDGFRA->SRC->KIT
PDGFRA->SRC->PTPN6
PDGFRA->SRC->SHC1
PDGFRA->SRC->STAT1
PDGFRA->SRC->STAT3
PDGFRA->SRC->STAT5A
PDGFRA->SRC->EGFR->CBL
PDGFRA->SRC->EGFR->CRK
PDGFRA->SRC->EGFR->PTPN1
PDGFRA->SRC->EGFR->STAT1


STAT5B is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PTPN1SRC->STAT5B
PTPN1MAPK1->EGFR->STAT5B
PTPN1SRC->EGFR->STAT5B
PTPN1CSNK2A1->CDC2->EGFR->STAT5B
SHC1CSK->SRC->STAT5B
SHC1MAPK1->EGFR->STAT5B
SHC1CSK->SRC->EGFR->STAT5B
SHC1SYK->PRKCA->EGFR->STAT5B
PTPN11MAPK3->EGFR->STAT5B
PTPN11PDGFRA->SRC->STAT5B
PTPN11PRKCA->EGFR->STAT5B
PTPN11PDGFRA->SRC->EGFR->STAT5B
CBLCSK->SRC->STAT5B
CBLPDGFRA->SRC->STAT5B
CBLCSK->SRC->EGFR->STAT5B
CBLPDGFRA->SRC->EGFR->STAT5B
CBLSYK->PRKCA->EGFR->STAT5B
STAP2SRC->STAT5B
STAT5AMAPK1->EGFR->STAT5B
STAT5AMAPK3->EGFR->STAT5B
STAT5APDGFRA->SRC->STAT5B
STAT5APDGFRA->SRC->EGFR->STAT5B
PTPN6SRC->EGFR->STAT5B
PTPN6SYK->PRKCA->EGFR->STAT5B
PTPN2CDC2->EGFR->STAT5B
PTPN2CDK5->SRC->STAT5B
PTPN2CDK5->SRC->EGFR->STAT5B
PDGFRBPDGFRA->SRC->STAT5B
PDGFRBPDGFRA->SRC->EGFR->STAT5B
INSRCSK->SRC->STAT5B
CRKPDGFRA->SRC->STAT5B
CRKPDGFRA->SRC->EGFR->STAT5B


The sequence of STAT5B

Amino acids in red are phosphorylation sites determined by MS/MS

MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSVDLDN 50
PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR 100
CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE 150
LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFGPLA QLSPQERLSR 200
ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD 250
ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 300
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA 350
TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRK 400

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