| JAK3 | -> | JAK1 | -> | STAT1 | JAK3 | -> | JAK1 | -> | STAT3 | MAPK1 | -> | EGFR | -> | CBL | MAPK1 | -> | EGFR | -> | CRK | MAPK1 | -> | EGFR | -> | PTPN1 | MAPK1 | -> | EGFR | -> | STAT1 | MAPK1 | -> | EGFR | -> | STAT5B | MAPK1 | -> | LCK | -> | CBL | MAPK1 | -> | LCK | -> | ESR1 | MAPK1 | -> | LCK | -> | IL2RB | MAPK1 | -> | LCK | -> | SHC1 | MAPK3 | -> | EGFR | -> | CBL | MAPK3 | -> | EGFR | -> | CRK | MAPK3 | -> | EGFR | -> | PTPN1 | MAPK3 | -> | EGFR | -> | STAT1 | MAPK3 | -> | EGFR | -> | STAT5B | MAPK3 | -> | LCK | -> | CBL | MAPK3 | -> | LCK | -> | ESR1 | MAPK3 | -> | LCK | -> | IL2RB | MAPK3 | -> | LCK | -> | SHC1 | PDGFRA | -> | SRC | -> | BMX | PDGFRA | -> | SRC | -> | CBL | PDGFRA | -> | SRC | -> | ESR1 | PDGFRA | -> | SRC | -> | KIT | PDGFRA | -> | SRC | -> | SHC1 | PDGFRA | -> | SRC | -> | STAT1 | PDGFRA | -> | SRC | -> | STAT3 | PDGFRA | -> | SRC | -> | STAT5B | PDGFRA | -> | SRC | -> | EGFR | -> | CBL | PDGFRA | -> | SRC | -> | EGFR | -> | CRK | PDGFRA | -> | SRC | -> | EGFR | -> | PTPN1 | PDGFRA | -> | SRC | -> | EGFR | -> | STAT1 | PDGFRA | -> | SRC | -> | EGFR | -> | STAT5B |
| Scaffold Protein(s) | Related Pathway(s) | PTPN1 | JAK2->STAT5A | PTPN1 | MAPK1->STAT5A | PTPN1 | SRC->STAT5A | SHC1 | CSK->LYN->STAT5A | SHC1 | CSK->SRC->STAT5A | PTPN11 | PDGFRA->SRC->STAT5A | EGFR | PAK1->MAP2K1->MAPK1->STAT5A | CBL | CSK->LYN->STAT5A | CBL | CSK->SRC->STAT5A | CBL | PDGFRA->SRC->STAT5A | STAT5B | PDGFRA->SRC->STAT5A | STAP2 | JAK2->STAT5A | STAP2 | SRC->STAT5A | PTPN2 | CDK5->SRC->STAT5A | PDGFRB | PDGFRA->SRC->STAT5A | INSR | CSK->SRC->STAT5A | CRK | PDGFRA->SRC->STAT5A |
|---|
The sequence of STAT5A
Amino acids in red are phosphorylation sites determined by MS/MS
MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN 50
PQDRAQATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQKTYDR 100
CPLELVRCIR HILYNEQRLV REANNCSSPA GILVDAMSQK HLQINQTFEE 150
LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFAQLA QLSPQERLSR 200
ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD 250
ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 300
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA 350
TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC 400
CVMEYHQATG TLSAHFRNMS LKRIKRADRR GAESVTEEKF TVLFESQFSV 450
GSNELVFQVK TLSLPVVVIV HGSQDHNATA TVLWDNAFAE PGRVPFAVPD 500
KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN SSSHLEDYSG 550
LSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK 600
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPERNL WNLKPFTTRD 650
FSIRSLADRL GDLSYLIYVF PDRPKDEVFS KYYTPVLAKA VDGYVKPQIK 700
QVVPEFVNAS ADAGGSSATY MDQAPSPAVC PQAPYNMYPQ NPDHVLDQDG 750
EFDLDETMDV ARHVEELLRR PMDSLDSRLS PPAGLFTSAR GSLS 800