RAF1 is a predicted scaffold protein, which is related to the following pathway(s).

MAP2K1->MAPK1->PAK1->BRAF
MAP2K2->MAPK3->LCK->IL2RB
MAP2K2->MAPK3->LCK->VAV1
MAPK1->MAP2K1->MAPK3->GRB10
PAK1->MAP2K1->MAPK1->GRB10
PAK1->MAP2K1->MAPK1->MYC
MAPK1->MAP2K1->MAPK3->LCK->IL2RB
MAPK1->MAP2K1->MAPK3->LCK->VAV1
MAPK1->PAK1->MAP2K1->MAPK3->GRB10
PAK1->MAP2K1->MAPK1->LCK->IL2RB
PAK1->MAP2K1->MAPK1->LCK->VAV1
MAPK1->PAK1->MAP2K1->MAPK3->LCK->IL2RB
MAPK1->PAK1->MAP2K1->MAPK3->LCK->VAV1


RAF1 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PAK1RAF1->MAP2K1->MAPK1->MBP
PAK1RAF1->MAP2K1->MAPK1->SMAD1
PAK1RAF1->MAP2K1->MAPK1->EGFR->GRB2
PAK1RAF1->MAP2K1->MAPK1->EGFR->HGS
PAK1RAF1->MAP2K1->MAPK1->EGFR->PLCG1
GRB10SRC->RAF1->MAP2K1->MAPK1->EGFR
PEBP4RAF1->MAP2K1
PRKCZSRC->RAF1->MAP2K1->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->GSK3B->RELA
PRKCZSRC->RAF1->MAP2K1->MAPK1->CASP9
PRKCZSRC->RAF1->MAP2K1->MAPK1->MBP
PRKCZSRC->RAF1->MAP2K1->MAPK1->RELA
PRKCZSRC->RAF1->MAP2K1->MAPK3->CASP9
PRKCZSRC->RAF1->MAP2K1->MAPK3->IRS1
PRKCZSRC->RAF1->MAP2K1->MAPK3->MBP
PRKCZSRC->RAF1->MAP2K1->MAPK1->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->MAPK1->GSK3B->RELA
PRKCZSRC->RAF1->MAP2K1->MAPK3->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->MAPK3->GSK3B->RELA
PDGFRBPDGFRA->SRC->RAF1
INSRCSK->SRC->RAF1
MAPK8IP3SRC->RAF1->MAP2K1
KSR2RAF1->MAP2K1->MAPK1
KSR2RAF1->MAP2K1->MAPK3
MAP2K1MAPK1->PAK1->RAF1
PBPRAF1->MAP2K1->MAPK1
BRAFRAF1->MAP2K1->MAPK1
BRAFRAF1->MAP2K1->MAPK3
PEBP1RAF1->MAP2K1->MAPK1
VAV1RAF1->MAP2K1->MAPK1->EGFR->CBL
VAV1RAF1->MAP2K1->MAPK1->EGFR->CRK
VAV1RAF1->MAP2K1->MAPK1->EGFR->GRB2
VAV1RAF1->MAP2K1->MAPK1->EGFR->PLCG1
VAV1RAF1->MAP2K1->MAPK1->LCK->CBL
VAV1RAF1->MAP2K1->MAPK1->LCK->PRKCQ
VAV1RAF1->MAP2K1->MAPK1->LCK->PTPN6
VAV1RAF1->MAP2K1->MAPK1->LCK->ZAP70->LCP2



RAF1 is a known signal protein, which is involved in the following pathway(s)

Scaffold Protein(s)Related Pathway(s)PMID
MAP3K1RAF1->ERK210969079
YWHAGPKC->RAF114-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1
SLC9A1MAP3K7->RAF120936779

Reference:MEKK1 binds raf-1 and the ERK2 cascade components.

PMID:10969079

Reference: negative regulation by 14-3-3 phosphorylation.

PMID:14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1

Reference:A human MAP kinase interactome.

PMID:20936779


The sequence of RAF1

Amino acids in red are phosphorylation sites determined by MS/MS

MEHIQGAWKT ISNGFGFKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD 50
PSKTSNTIRV FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR 100
LLHEHKGKKA RLDWNTDAAS LIGEELQVDF LDHVPLTTHN FARKTFLKLA 150
FCDICQKFLL NGFRCQTCGY KFHEHCSTKV PTMCVDWSNI RQLLLFPNST 200
IGDSGVPALP SLTMRRMRES VSRMPVSSQH RYSTPHAFTF NTSSPSSEGS 250
LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL 300
SPTGWSQPKT PVPAQRERAP VSGTQEKNKI RPRGQRDSSY YWEIEASEVM 350
LSTRIGSGSF GTVYKGKWHG DVAVKILKVV DPTPEQFQAF RNEVAVLRKT 400
RHVNILLFMG YMTKDNLAIV TQWCEGSSLY KHLHVQETKF QMFQLIDIAR 450
QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL TVKIGDFGLA TVKSRWSGSQ 500
QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE LMTGELPYSH 550
INNRDQIIFM VGRGYASPDL SKLYKNCPKA MKRLVADCVK KVKEERPLFP 600
QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF 650

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