PTPN6 is a predicted scaffold protein, which is related to the following pathway(s).

LCK->ZAP70->GAB2
LCK->ZAP70->LCP2
LCK->ZAP70->SHC1
SRC->ABL1->BCR
SRC->ABL1->CBL
SRC->EGFR->CBL
SRC->EGFR->GRB2
SRC->EGFR->STAT5B
SYK->PRKCA->CD5
SYK->PRKCA->KIT
SYK->PRKCA->MYH9
SYK->PTK2B->ESR1
JAK3->JAK1->TYK2->IFNAR1
SYK->PRKCA->EGFR->CBL
SYK->PRKCA->EGFR->GRB2
SYK->PRKCA->EGFR->STAT5B
SYK->PRKCA->INSR->CBL
SYK->PRKCA->INSR->DOK1
SYK->PRKCA->INSR->PIK3R1
SYK->PRKCA->INSR->SHC1


PTPN6 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PECAM1CSK->SRC->PTPN6
PECAM1MAPK1->LCK->PTPN6
SHC1CSK->SRC->PTPN6
SHC1MAPK1->LCK->PTPN6
SHC1SYK->PRKCA->PTPN6
CD33SRC->PTPN6
PTPN11MAPK3->LCK->PTPN6
PTPN11PDGFRA->SRC->PTPN6
CBLCSK->SRC->PTPN6
CBLPDGFRA->SRC->PTPN6
CBLSYK->PRKCA->PTPN6
DOK1CSK->SRC->PTPN6
STAT5BPDGFRA->SRC->PTPN6
CAV1CSK->SRC->PTPN6
CAV1PDGFRA->SRC->PTPN6
INSRCSK->SRC->PTPN6
IFNAR1MAPK1->LCK->PTPN6
CEACAM1SRC->PTPN6
KHDRBS1MAPK1->LCK->PTPN6
GAB2SRC->PTPN6
GAB2MAPK1->LCK->PTPN6
GAB2MAPK3->LCK->PTPN6
VAV1RAF1->MAP2K1->MAPK1->LCK->PTPN6


The sequence of PTPN6

Amino acids in red are phosphorylation sites determined by MS/MS

MLSRGWFHRD LSGLDAETLL KGRGVHGSFL ARPSRKNQGD FSLSVRVGDQ 50
VTHIRIQNSG DFYDLYGGEK FATLTELVEY YTQQQGVLQD RDGTIIHLKY 100
PLNCSDPTSE RWYHGHMSGG QAETLLQAKG EPWTFLVRES LSQPGDFVLS 150
VLSDQPKAGP GSPLRVTHIK VMCEGGRYTV GGLETFDSLT DLVEHFKKTG 200
IEEASGAFVY LRQPYYATRV NAADIENRVL ELNKKQESED TAKAGFWEEF 250
ESLQKQEVKN LHQRLEGQRP ENKGKNRYKN ILPFDHSRVI LQGRDSNIPG 300
SDYINANYIK NQLLGPDENA KTYIASQGCL EATVNDFWQM AWQENSRVIV 350
MTTREVEKGR NKCVPYWPEV GMQRAYGPYS VTNCGEHDTT EYKLRTLQVS 400
PLDNGDLIRE IWHYQYLSWP DHGVPSEPGG VLSFLDQINQ RQESLPHAGP 450
IIVHCSAGIG RTGTIIVIDM LMENISTKGL DCDIDIQKTI QMVRAQRSGM 500
VQTEAQYKFI YVAIAQFIET TKKKLEVLQS QKGQESEYGN ITYPPAMKNA 550
HAKASRTSSK HKEDVYENLH TKNKREEKVK KQRSADKEKS KGSLKRK 600

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