PTPN11 is a predicted scaffold protein, which is related to the following pathway(s).

KDR->FLT4->SHC1
MAPK3->EGFR->CBL
MAPK3->EGFR->GAB1
MAPK3->EGFR->GRB2
MAPK3->EGFR->PLCG1
MAPK3->EGFR->STAT1
MAPK3->EGFR->STAT5B
MAPK3->LCK->CBL
MAPK3->LCK->CD33
MAPK3->LCK->PLCG2
MAPK3->LCK->PTPN6
MAPK3->LCK->SHC1
MAPK3->LCK->SLAMF1
MAPK3->LCK->SOCS3
PDGFRA->SRC->BCAR1
PDGFRA->SRC->BDKRB2
PDGFRA->SRC->CAV1
PDGFRA->SRC->CBL
PDGFRA->SRC->CD33
PDGFRA->SRC->IGF1R
PDGFRA->SRC->KIT
PDGFRA->SRC->MPZL1
PDGFRA->SRC->PIK3R1
PDGFRA->SRC->PLCG2
PDGFRA->SRC->PTPN6
PDGFRA->SRC->PXN
PDGFRA->SRC->SHC1
PDGFRA->SRC->SPRY2
PDGFRA->SRC->STAT1
PDGFRA->SRC->STAT3
PDGFRA->SRC->STAT5A
PDGFRA->SRC->STAT5B
PDGFRB->FYN->CAV1
PDGFRB->FYN->CBL
PDGFRB->FYN->PLCG2
PDGFRB->FYN->SHC1
PDGFRB->FYN->SLAMF1
PRKCA->EGFR->CBL
PRKCA->EGFR->GAB1
PRKCA->EGFR->GRB2
PRKCA->EGFR->PLCG1
PRKCA->EGFR->STAT1
PRKCA->EGFR->STAT5B
PRKCA->INSR->CBL
PRKCA->INSR->GAB1
PRKCA->INSR->PIK3R1
PRKCA->INSR->SHC1
PDGFRA->SRC->EGFR->CBL
PDGFRA->SRC->EGFR->GAB1
PDGFRA->SRC->EGFR->GRB2
PDGFRA->SRC->EGFR->PLCG1
PDGFRA->SRC->EGFR->STAT1
PDGFRA->SRC->EGFR->STAT5B
PDGFRA->SRC->PTK2->PXN


PTPN11 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
SRCSYK->PRKCA->ADRBK1->PDGFRB->PTPN11


The sequence of PTPN11

Amino acids in red are phosphorylation sites determined by MS/MS

MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA 50
VTHIKIQNTG DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY 100
PLNCADPTSE RWFHGHLSGK EAEKLLTEKG KHGSFLVRES QSHPGDFVLS 150
VRTGDDKGES NDGKSKVTHV MIRCQELKYD VGGGERFDSL TDLVEHYKKN 200
PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT DKVKQGFWEE 250
FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 300
VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS 350
RVIVMTTKEV ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE 400
LKLSKVGQGN TERTVWQYHF RTWPDHGVPS DPGGVLDFLE EVHHKQESIM 450
DAGPVVVHCS AGIGRTGTFI VIDILIDIIR EKGVDCDIDV PKTIQMVRSQ 500
RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH EYTNIKYSLA 550
DQTSGDQSPL PPCTPTPPCA EMREDSARVY ENVGLMQQQK SFR 600

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