PTPN1 is a predicted scaffold protein, which is related to the following pathway(s).

JAK2->STAT5A
MAPK1->CAPN2
MAPK1->STAT5A
SRC->BCAR1
SRC->CAV1
SRC->CDH2
SRC->CTNNB1
SRC->ESR1
SRC->IGF1R
SRC->NFKBIA
SRC->STAT5A
SRC->STAT5B
CDC2->CSNK2A1->AKT1
CDC2->CSNK2A1->BCR
CDC2->CSNK2A1->NFKBIA
MAPK1->EGFR->GRB2
MAPK1->EGFR->STAT5B
MAPK1->GSK3B->ESR1
SRC->EGFR->GRB2
SRC->EGFR->STAT5B
CSNK2A1->CDC2->EGFR->GRB2
CSNK2A1->CDC2->EGFR->STAT5B


PTPN1 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
GRB2PDGFRA->SRC->EGFR->PTPN1
PIN1PLK1->WEE1->CDC2->PTPN1
STAT5BMAPK1->EGFR->PTPN1
STAT5BPDGFRA->SRC->EGFR->PTPN1
IGF1RCSK->SRC->EGFR->PTPN1
CAV1MAPK1->EGFR->PTPN1
CAV1MAPK3->EGFR->PTPN1
CAV1CSK->SRC->EGFR->PTPN1
CAV1PDGFRA->SRC->EGFR->PTPN1
STAT5AMAPK1->EGFR->PTPN1
STAT5AMAPK3->EGFR->PTPN1
STAT5APDGFRA->SRC->EGFR->PTPN1
PDGFRBPDGFRA->SRC->EGFR->PTPN1
BCAR1SRC->EGFR->PTPN1


The sequence of PTPN1

Amino acids in red are phosphorylation sites determined by MS/MS

MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS 50
PFDHSRIKLH QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW 100
EQKSRGVVML NRVMEKGSLK CAQYWPQKEE KEMIFEDTNL KLTLISEDIK 150
SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE 200
SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVL 250
LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE 300
PPPEHIPPPP RPPKRILEPH NGKCREFFPN HQWVKEETQE DKDCPIKEEK 350
GSPLNAAPYG IESMSQDTEV RSRVVGGSLR GAQAASPAKG EPSLPEKDED 400
HALSYWKPFL VNMCVATVLT AGAYLCYRFL FNSNT

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