PTK2 is a predicted scaffold protein, which is related to the following pathway(s).

CSK->FYN->CD79B
CSK->FYN->SHC1
CSK->FYN->TGFB1I1
CSK->LYN->CD79B
CSK->SRC->BCAR1
CSK->SRC->BMX
CSK->SRC->GSN
CSK->SRC->ITGB3
CSK->SRC->PIK3R1
CSK->SRC->PXN
CSK->SRC->SHC1
CSK->SRC->STAT1
PDGFRB->FYN->CD79B
PDGFRB->FYN->SHC1
PDGFRB->FYN->TGFB1I1
CSK->SRC->EGFR->CRK
CSK->SRC->EGFR->GRB2
CSK->SRC->EGFR->PLCG1
CSK->SRC->EGFR->STAT1
CSK->SRC->IGF1R->CRK


PTK2 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
FGRCSK->SRC->PTK2
PKD1SRC->PTK2->ACTN1
SHC1CSK->SRC->PTK2
PTPN11PDGFRA->SRC->PTK2->PXN
PLCG1PDGFRA->SRC->PTK2
EGFRCSK->SRC->PTK2->PXN
GRB2PDGFRA->SRC->PTK2->PXN
IGF1RCSK->SRC->PTK2->PXN
PTPRHPTK2->PXN
PDGFRBPDGFRA->SRC->PTK2
CSKSRC->PTK2->PXN
PXNCSK->SRC->PTK2
INSRCSK->SRC->PTK2
GSNCSK->SRC->PTK2->PXN
CRKPDGFRA->SRC->PTK2->PXN
PIK3R1PDGFRA->SRC->PTK2->PXN
BCAR1SRC->PTK2->PXN
ITGB3PDGFRA->SRC->PTK2
DDEF1SRC->PTK2->PXN


The sequence of PTK2

Amino acids in red are phosphorylation sites determined by MS/MS

MAAAYLDPNL NHTPNSSTKT HLGTGMERSP GAMERVLKVF HYFESNSEPT 50
TWASIIRHGD ATDVRGIIQK IVDSHKVKHV ACYGFRLSHL RSEEVHWLHV 100
DMGVSSVREK YELAHPPEEW KYELRIRYLP KGFLNQFTED KPTLNFFYQQ 150
VKSDYMLEIA DQVDQEIALK LGCLEIRRSY WEMRGNALEK KSNYEVLEKD 200
VGLKRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI LKFFEILSPV 250
YRFDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGCNP THLADFTQVQ 300
TIQYSNSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL 350
VNGTSQSFII RPQKEGERAL PSIPKLANSE KQGMRTHAVS VSETDDYAEI 400
IDEEDTYTMP STRDYEIQRE RIELGRCIGE GQFGDVHQGI YMSPENPALA 450
VAIKTCKNCT SDSVREKFLQ EALTMRQFDH PHIVKLIGVI TENPVWIIME 500
LCTLGELRSF LQVRKYSLDL ASLILYAYQL STALAYLESK RFVHRDIAAR 550
NVLVSSNDCV KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT 600
SASDVWMFGV CMWEILMHGV KPFQGVKNND VIGRIENGER LPMPPNCPPT 650
LYSLMTKCWA YDPSRRPRFT ELKAQLSTIL EEEKAQQEER MRMESRRQAT 700
VSWDSGGSDE APPKPSRPGY PSPRSSEGFY PSPQHMVQTN HYQDSTVLDL 750
RGIGQVLPTH LMEERLIRQQ QEMEEDQRWL EKEERFLKPD VRLSRGSIDR 800
EDGSLQGPIG NQHIYQPVGK PDPAAPPKKP PRPGAPGHLG SLASLSSPAD 850
SYNEGVKLQP QEISPPPTAN LDRSNDKVYE NVTGLVKAVI EMSSKIQPAP 900
PEEYVPMVKE VGLALRTLLA TVDETIPLLP ASTHREIEMA QKLLNSDLGE 950
LINKMKLAQQ YVMTSLQQEY KKQMLTAAHA LAVDAKNLLD VIDQARLKML 1000
GQTRPH

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