PLCG2 is a predicted scaffold protein, which is related to the following pathway(s).

LCK->ITK->TEC
LYN->BTK->TEC
LYN->BTK->ITK->TEC


PLCG2 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
SHC1CSK->FYN->PLCG2
SHC1CSK->LYN->PLCG2
SHC1CSK->SRC->PLCG2
SHC1MAPK1->LCK->PLCG2
SHC1PDGFRB->FYN->PLCG2
LIME1LCK->PLCG2
LIME1LYN->PLCG2
SH3BP2FYN->PLCG2
SH3BP2LCK->PLCG2
PTPN11MAPK3->LCK->PLCG2
PTPN11PDGFRA->SRC->PLCG2
PTPN11PDGFRB->FYN->PLCG2
PRKD1SRC->ABL1->BTK->PLCG2
CD19ABL1->BTK->PLCG2
CD19LYN->BTK->PLCG2
DAPP1LCK->PLCG2
DAPP1LYN->PLCG2
DAPP1SRC->PLCG2
DAPP1LYN->BTK->PLCG2
TECLYN->BTK->PLCG2
FCER1GLYN->PLCG2
FCER1GLYN->BTK->PLCG2
KHDRBS1LYN->BTK->PLCG2
KHDRBS1MAPK1->LCK->PLCG2
GAB2LYN->PLCG2
GAB2SRC->PLCG2
GAB2MAPK1->LCK->PLCG2
GAB2MAPK3->LCK->PLCG2


The sequence of PLCG2

Amino acids in red are phosphorylation sites determined by MS/MS

MSTTVNVDSL AEYEKSQIKR ALELGTVMTV FSFRKSTPER RTVQVIMETR 50
QVAWSKTADK IEGFLDIMEI KEIRPGKNSK DFERAKAVRQ KEDCCFTILY 100
GTQFVLSTLS LAADSKEDAV NWLSGLKILH QEAMNASTPT IIESWLRKQI 150
YSVDQTRRNS ISLRELKTIL PLINFKVSSA KFLKDKFVEI GAHKDELSFE 200
QFHLFYKKLM FEQQKSILDE FKKDSSVFIL GNTDRPDASA VYLHDFQRFL 250
IHEQQEHWAQ DLNKVRERMT KFIDDTMRET AEPFLFVDEF LTYLFSRENS 300
IWDEKYDAVD MQDMNNPLSH YWISSSHNTY LTGDQLRSES SPEAYIRCLR 350
MGCRCIELDC WDGPDGKPVI YHGWTRTTKI KFDDVVQAIK DHAFVTSSFP 400
VILSIEEHCS VEQQRHMAKA FKEVFGDLLL TKPTEASADQ LPSPSQLREK 450
IIIKHKKLGP RGDVDVNMED KKDEHKQQGE LYMWDSIDQK WTRHYCAIAD 500
AKLSFSDDIE QTMEEEVPQD IPPTELHFGE KWFHKKVEKR TSAEKLLQEY 550
CMETGGKDGT FLVRESETFP NDYTLSFWRS GRVQHCRIRS TMEGGTLKYY 600
LTDNLTFSSI YALIQHYRET HLRCAEFELR LTDPVPNPNP HESKPWYYDS 650
LSRGEAEDML MRIPRDGAFL IRKREGSDSY AITFRARGKV KHCRINRDGR 700
HFVLGTSAYF ESLVELVSYY EKHSLYRKMR LRYPVTPELL ERYNMERDIN 750
SLYDVSRMYV DPSEINPSMP QRTVKALYDY KAKRSDELSF CRGALIHNVS 800
KEPGGWWKGD YGTRIQQYFP SNYVEDISTA DFEELEKQII EDNPLGSLCR 850
GILDLNTYNV VKAPQGKNQK SFVFILEPKQ QGDPPVEFAT DRVEELFEWF 900
QSIREITWKI DTKENNMKYW EKNQSIAIEL SDLVVYCKPT SKTKDNLENP 950
DFREIRSFVE TKADSIIRQK PVDLLKYNQK GLTRVYPKGQ RVDSSNYDPF 1000
RLWLCGSQMV ALNFQTADKY MQMNHALFSL NGRTGYVLQP ESMRTEKYDP 1050
MPPESQRKIL MTLTVKVLGA RHLPKLGRSI ACPFVEVEIC GAEYDNNKFK 1100
TTVVNDNGLS PIWAPTQEKV TFEIYDPNLA FLRFVVYEED MFSDPNFLAH 1150
ATYPIKAVKS GFRSVPLKNG YSEDIELASL LVFCEMRPVL ESEEELYSSC 1200
RQLRRRQEEL NNQLFLYDTH QNLRNANRDA LVKEFSVNEN QLQLYQEKCN 1250
KRLREKRVSN SKFYS

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