| LCK | -> | ITK | -> | CD28 | LCK | -> | ITK | -> | TEC | LCK | -> | ZAP70 | -> | LCP2 | LCK | -> | ZAP70 | -> | SHC1 | LYN | -> | BTK | -> | TEC | LYN | -> | BTK | -> | WAS | PDGFRA | -> | SRC | -> | CBL | PDGFRA | -> | SRC | -> | GNB2L1 | PDGFRA | -> | SRC | -> | KIT | PDGFRA | -> | SRC | -> | PTK2 | PDGFRA | -> | SRC | -> | SHC1 | PDGFRB | -> | FYN | -> | CBL | PDGFRB | -> | FYN | -> | SHC1 | LYN | -> | BTK | -> | ITK | -> | CD28 | LYN | -> | BTK | -> | ITK | -> | TEC | PDGFRA | -> | SRC | -> | ABL1 | -> | BCR | PDGFRA | -> | SRC | -> | ABL1 | -> | CBL | PDGFRA | -> | SRC | -> | ABL1 | -> | PRKD1 | PDGFRA | -> | SRC | -> | EGFR | -> | CBL | PDGFRA | -> | SRC | -> | EGFR | -> | GAB1 | PDGFRA | -> | SRC | -> | EGFR | -> | GRB2 | PDGFRA | -> | SRC | -> | EGFR | -> | RASA1 | PDGFRA | -> | SRC | -> | ABL1 | -> | BTK | -> | TEC | PDGFRA | -> | SRC | -> | ABL1 | -> | BTK | -> | WAS | PDGFRA | -> | SRC | -> | ABL1 | -> | BTK | -> | ITK | -> | CD28 | PDGFRA | -> | SRC | -> | ABL1 | -> | BTK | -> | ITK | -> | TEC |
| Scaffold Protein(s) | Related Pathway(s) | PAK1 | RAF1->MAP2K1->MAPK1->EGFR->PLCG1 | MET | SRC->EGFR->PLCG1 | PLD2 | PRKCA->EGFR->PLCG1 | PLD2 | CSK->SRC->EGFR->PLCG1 | SHC1 | MAPK1->EGFR->PLCG1 | SHC1 | SYK->PRKCA->PLCG1 | SHC1 | CSK->SRC->EGFR->PLCG1 | SHC1 | SYK->PRKCA->EGFR->PLCG1 | LYN | CSK->SRC->EGFR->PLCG1 | SH3BP2 | FGFR1->PLCG1 | SH3BP2 | SYK->PLCG1 | PTPN11 | MAPK3->EGFR->PLCG1 | PTPN11 | PRKCA->EGFR->PLCG1 | PTPN11 | PDGFRA->SRC->EGFR->PLCG1 | CBL | SYK->PRKCA->PLCG1 | CBL | CSK->SRC->EGFR->PLCG1 | CBL | PDGFRA->SRC->EGFR->PLCG1 | CBL | SYK->PRKCA->EGFR->PLCG1 | GRB2 | PDGFRA->SRC->EGFR->PLCG1 | PTK2 | CSK->SRC->EGFR->PLCG1 | PRKD1 | SRC->EGFR->PLCG1 | BTK | SYK->PRKCA->PLCG1 | PDGFRB | PDGFRA->SRC->EGFR->PLCG1 | RASA1 | CSK->SRC->EGFR->PLCG1 | WAS | SRC->EGFR->PLCG1 | GAB1 | MAPK1->EGFR->PLCG1 | GAB1 | MAPK3->EGFR->PLCG1 | VAV1 | RAF1->MAP2K1->MAPK1->EGFR->PLCG1 |
|---|
PLCG1 is a known signal protein, which is involved in the following pathway(s)
| Scaffold Protein(s) | Related Pathway(s) | PMID |
|---|---|---|
| SLC9A3R2 | P2Y1R->PLCG1 | 15901899 |
Reference:P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2.
PMID:15901899
The sequence of PLCG1
Amino acids in red are phosphorylation sites determined by MS/MS
MAGAASPCAN GCGPGAPSDA EVLHLCRSLE VGTVMTLFYS KKSQRPERKT 50
FQVKLETRQI TWSRGADKIE GAIDIREIKE IRPGKTSRDF DRYQEDPAFR 100
PDQSHCFVIL YGMEFRLKTL SLQATSEDEV NMWIKGLTWL MEDTLQAPTP 150
LQIERWLRKQ FYSVDRNRED RISAKDLKNM LSQVNYRVPN MRFLRERLTD 200
LEQRSGDITY GQFAQLYRSL MYSAQKTMDL PFLEASTLRA GERPELCRVS 250
LPEFQQFLLD YQGELWAVDR LQVQEFMLSF LRDPLREIEE PYFFLDEFVT 300
FLFSKENSVW NSQLDAVCPD TMNNPLSHYW ISSSHNTYLT GDQFSSESSL 350
EAYARCLRMG CRCIELDCWD GPDGMPVIYH GHTLTTKIKF SDVLHTIKEH 400
AFVASEYPVI LSIEDHCSIA QQRNMAQYFK KVLGDTLLTK PVEISADGLP 450
SPNQLKRKIL IKHKKLAEGS AYEEVPTSMM YSENDISNSI KNGILYLEDP 500
VNHEWYPHYF VLTSSKIYYS EETSSDQGNE DEEEPKEVSS STELHSNEKW 550
FHGKLGAGRD GRHIAERLLT EYCIETGAPD GSFLVRESET FVGDYTLSFW 600
RNGKVQHCRI HSRQDAGTPK FFLTDNLVFD SLYDLITHYQ QVPLRCNEFE 650
MRLSEPVPQT NAHESKEWYH ASLTRAQAEH MLMRVPRDGA FLVRKRNEPN 700
SYAISFRAEG KIKHCRVQQE GQTVMLGNSE FDSLVDLISY YEKHPLYRKM 750
KLRYPINEEA LEKIGTAEPD YGALYEGRNP GFYVEANPMP TFKCAVKALF 800
DYKAQREDEL TFIKSAIIQN VEKQEGGWWR GDYGGKKQLW FPSNYVEEMV 850
NPVALEPERE HLDENSPLGD LLRGVLDVPA CQIAIRPEGK NNRLFVFSIS 900
MASVAHWSLD VAADSQEELQ DWVKKIREVA QTADARLTEG KIMERRKKIA 950
LELSELVVYC RPVPFDEEKI GTERACYRDM SSFPETKAEK YVNKAKGKKF 1000
LQYNRLQLSR IYPKGQRLDS SNYDPLPMWI CGSQLVALNF QTPDKPMQMN 1050
QALFMTGRHC GYVLQPSTMR DEAFDPFDKS SLRGLEPCAI SIEVLGARHL 1100
PKNGRGIVCP FVEIEVAGAE YDSTKQKTEF VVDNGLNPVW PAKPFHFQIS 1150
NPEFAFLRFV VYEEDMFSDQ NFLAQATFPV KGLKTGYRAV PLKNNYSEDL 1200
ELASLLIKID IFPAKQENGD LSPFSGTSLR ERGSDASGQL FHGRAREGSF 1250
ESRYQQPFED FRISQEHLAD HFDSRERRAP RRTRVNGDNR L 1300