PIK3R1 is a predicted scaffold protein, which is related to the following pathway(s).

JAK3->JAK1->TYK2->IFNAR1
PDGFRA->SRC->ABL1->CBL
PDGFRA->SRC->ABL1->CRK
PDGFRA->SRC->ABL1->CRKL
PDGFRA->SRC->ABL1->NFKBIA
PDGFRA->SRC->EGFR->CBL
PDGFRA->SRC->EGFR->CRK
PDGFRA->SRC->EGFR->GAB1
PDGFRA->SRC->EGFR->GRB2
PDGFRA->SRC->EGFR->HGS
PDGFRA->SRC->EGFR->RASA1
PDGFRA->SRC->IGF1R->CRK
PDGFRA->SRC->PTK2->PXN


PIK3R1 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PECAM1CSK->SRC->PIK3R1
SHC1CSK->SRC->PIK3R1
SHC1SYK->PRKCA->INSR->PIK3R1
PTPN11PDGFRA->SRC->PIK3R1
PTPN11PRKCA->INSR->PIK3R1
CBLCSK->SRC->PIK3R1
CBLPDGFRA->SRC->PIK3R1
CBLSYK->PRKCA->INSR->PIK3R1
DOK1CSK->SRC->PIK3R1
PTK2CSK->SRC->PIK3R1
DNM1CDK5->SRC->PIK3R1
SYN1CDK5->SRC->PIK3R1
IGF1RCSK->SRC->PIK3R1
SHBPDGFRA->SRC->PIK3R1
PTPN6SYK->PRKCA->INSR->PIK3R1
PDGFRBPDGFRA->SRC->PIK3R1
PXNCSK->SRC->PIK3R1
INSRCSK->SRC->PIK3R1
CRKPDGFRA->SRC->PIK3R1
RASA1CSK->SRC->PIK3R1
GAB2SRC->PIK3R1


The sequence of PIK3R1

Amino acids in red are phosphorylation sites determined by MS/MS

MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGQEARP 50
EEIGWLNGYN ETTGERGDFP GTYVEYIGRK KISPPTPKPR PPRPLPVAPG 100
SSKTEADVEQ QALTLPDLAE QFAPPDIAPP LLIKLVEAIE KKGLECSTLY 150
RTQSSSNLAE LRQLLDCDTP SVDLEMIDVH VLADAFKRYL LDLPNPVIPA 200
AVYSEMISLA PEVQSSEEYI QLLKKLIRSP SIPHQYWLTL QYLLKHFFKL 250
SQTSSKNLLN ARVLSEIFSP MLFRFSAASS DNTENLIKVI EILISTEWNE 300
RQPAPALPPK PPKPTTVANN GMNNNMSLQD AEWYWGDISR EEVNEKLRDT 350
ADGTFLVRDA STKMHGDYTL TLRKGGNNKL IKIFHRDGKY GFSDPLTFSS 400
VVELINHYRN ESLAQYNPKL DVKLLYPVSK YQQDQVVKED NIEAVGKKLH 450
EYNTQFQEKS REYDRLYEEY TRTSQEIQMK RTAIEAFNET IKIFEEQCQT 500
QERYSKEYIE KFKREGNEKE IQRIMHNYDK LKSRISEIID SRRRLEEDLK 550
KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN 600
ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE 650
SSKQGCYACS VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH 700
TSLVQHNDSL NVTLAYPVYA QQRR

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