MAPK8 is a predicted scaffold protein, which is related to the following pathway(s).

MAP3K1->MAP2K7->MAPK8->MAPK8IP1
MAP3K11->MAP2K4->MAPK8->MAPK8IP1
MAP3K5->MAP2K4->MAPK8->MAPK8IP1
MAP2K7->MAPK8->MAPK8IP1


MAPK8 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
SH2D3AMAPK8->SFN
DUSP22MAP2K4->MAPK8
DUSP22MAP2K7->MAPK8
MAP3K2MAP2K7->MAPK8->SFN
MAP3K2MAP2K7->MAPK8->YWHAB
MAP3K2MAP2K7->MAPK8->YWHAZ
MAP3K2MAP3K5->MAP2K4->MAPK8->SFN
MAP3K2MAP3K5->MAP2K4->MAPK8->YWHAB
MAP3K2MAP3K5->MAP2K4->MAPK8->YWHAZ
MAP2K7MAP3K11->MAP2K4->MAPK8->MAPK8IP1
MAP2K7MAP3K5->MAP2K4->MAPK8->MAPK8IP1
MAPK14MAP2K4->MAPK8->ATF2
MAPK14MAP2K4->MAPK8->BCL2
MAPK8IP3MAP3K1->MAP2K7->MAPK8->MAPK8IP1
MAPK8IP3MAP3K11->MAP2K4->MAPK8->MAPK8IP1
MAPK8IP3MAP3K5->MAP2K4->MAPK8->MAPK8IP1
DUSP16MAPK8->MAPK8IP1
MAP2K4MAP3K1->MAP2K7->MAPK8
MAPK8IP2MAP2K7->MAPK8->MAPK8IP1



MAPK8 is a known signal protein, which is involved in the following pathway(s)

Scaffold Protein(s)Related Pathway(s)PMID
SH3RF1ARHGEF2->MAP3K11->MAP2K4->MAP2K7->MAPK812514131

Reference:POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.

PMID:12514131


The sequence of MAPK8

Amino acids in red are phosphorylation sites determined by MS/MS

MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER 50
NVAIKKLSRP FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE 100
FQDVYIVMEL MDANLCQVIQ MELDHERMSY LLYQMLCGIK HLHSAGIIHR 150
DLKPSNIVVK SDCTLKILDF GLARTAGTSF MMTPYVVTRY YRAPEVILGM 200
GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ LGTPCPEFMK 250
KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE 350
EWKELIYKEV MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS 400
SMSTDPTLAS DTDSSLEAAA GPLGCCR

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