MAPK3 is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PRKCZMAPK1->MAP2K1->MAPK3->CASP9
PRKCZMAPK1->MAP2K1->MAPK3->IRS1
PRKCZMAPK1->MAP2K1->MAPK3->MBP
PRKCZMAPK1->MAP2K1->MAPK3->GSK3B->PSEN1
PRKCZMAPK1->MAP2K1->MAPK3->GSK3B->RELA
PRKCZSRC->RAF1->MAP2K1->MAPK3->CASP9
PRKCZSRC->RAF1->MAP2K1->MAPK3->IRS1
PRKCZSRC->RAF1->MAP2K1->MAPK3->MBP
PRKCZSRC->RAF1->MAP2K1->MAPK3->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->MAPK3->GSK3B->RELA
KRT8P9MAPK3->EGFR->ANXA1
DUSP3MAP2K2->MAPK3->EGFR->STAT1
ELK1MAPK1->MAP2K1->MAPK3->CEBPB
ELK1MAPK1->MAP2K1->MAPK3->FOS
ELK1MAPK1->MAP2K1->MAPK3->GRB10
PTPN11MAPK3->EGFR->CBL
PTPN11MAPK3->EGFR->GAB1
PTPN11MAPK3->EGFR->GRB2
PTPN11MAPK3->EGFR->PLCG1
PTPN11MAPK3->EGFR->STAT1
PTPN11MAPK3->EGFR->STAT5B
PTPN11MAPK3->LCK->CBL
PTPN11MAPK3->LCK->CD33
PTPN11MAPK3->LCK->PLCG2
PTPN11MAPK3->LCK->PTPN6
PTPN11MAPK3->LCK->SHC1
PTPN11MAPK3->LCK->SLAMF1
PTPN11MAPK3->LCK->SOCS3
RPS6KA4MAPK1->MAP2K1->MAPK3->FOS
CAV1MAPK3->EGFR->PTPN1
MAP2K1IP1MAP2K2->MAPK3
MAP2K1IP1MAPK1->MAP2K1->MAPK3
STAT5AMAPK3->EGFR->CBL
STAT5AMAPK3->EGFR->CRK
STAT5AMAPK3->EGFR->PTPN1
STAT5AMAPK3->EGFR->STAT1
STAT5AMAPK3->EGFR->STAT5B
STAT5AMAPK3->LCK->CBL
STAT5AMAPK3->LCK->ESR1
STAT5AMAPK3->LCK->IL2RB
STAT5AMAPK3->LCK->SHC1
MAPK14MAPK1->MAP2K1->MAPK3->DUSP1
MAPK14MAPK1->MAP2K1->MAPK3->DUSP6
MAPK14MAPK1->MAP2K1->MAPK3->ELK1
MAPK14MAPK1->MAP2K1->MAPK3->ESR1
MAPK14MAPK1->MAP2K1->MAPK3->MBP
MAPK14MAPK1->MAP2K1->MAPK3->MKNK1
MAPK14MAPK1->MAP2K1->MAPK3->NFATC4
MAPK14MAPK1->MAP2K1->MAPK3->EGFR->GRB2
MAPK14MAPK1->MAP2K1->MAPK3->EGFR->STAT1
RAF1MAP2K2->MAPK3->LCK->IL2RB
RAF1MAP2K2->MAPK3->LCK->VAV1
RAF1MAPK1->MAP2K1->MAPK3->GRB10
RAF1MAPK1->MAP2K1->MAPK3->LCK->IL2RB
RAF1MAPK1->MAP2K1->MAPK3->LCK->VAV1
RAF1MAPK1->PAK1->MAP2K1->MAPK3->GRB10
RAF1MAPK1->PAK1->MAP2K1->MAPK3->LCK->IL2RB
RAF1MAPK1->PAK1->MAP2K1->MAPK3->LCK->VAV1
CASP9MAP2K2->MAPK3->CAPN2
CASP9MAPK1->MAP2K1->MAPK3->CAPN2
KSR2MAP3K8->MAP2K1->MAPK3
KSR2MAPK1->MAP2K1->MAPK3
KSR2RAF1->MAP2K1->MAPK3
BCL3MAPK3->GSK3B->NFKB1
GAB1MAPK3->EGFR->CRK
GAB1MAPK3->EGFR->GRB2
GAB1MAPK3->EGFR->PLCG1
GAB2MAPK3->ETV6
GAB2MAPK3->EGFR->GRB2
GAB2MAPK3->LCK->PLCG2
GAB2MAPK3->LCK->PTPN6
GAB2MAPK3->LCK->SHC1
GAB2MAPK3->LCK->ZAP70->SHC1
BRAFMAPK1->MAP2K1->MAPK3
BRAFRAF1->MAP2K1->MAPK3
RPS6KA2MAPK1->MAP2K1->MAPK3



MAPK3 is a known signal protein, which is involved in the following pathway(s)

Scaffold Protein(s)Related Pathway(s)PMID
SPAG9MAPK3->MAP2K615767678

Reference:Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.

PMID:15767678


The sequence of MAPK3

Amino acids in red are phosphorylation sites determined by MS/MS

MAAAAAQGGG GGEPRRTEGV GPGVPGEVEM VKGQPFDVGP RYTQLQYIGE 50
GAYGMVSSAY DHVRKTRVAI KKISPFEHQT YCQRTLREIQ ILLRFRHENV 100
IGIRDILRAS TLEAMRDVYI VQDLMETDLY KLLKSQQLSN DHICYFLYQI 150
LRGLKYIHSA NVLHRDLKPS NLLINTTCDL KICDFGLARI ADPEHDHTGF 200
LTEYVATRWY RAPEIMLNSK GYTKSIDIWS VGCILAEMLS NRPIFPGKHY 250
LDQLNHILGI LGSPSQEDLN CIINMKARNY LQSLPSKTKV AWAKLFPKSD 300
SKALDLLDRM LTFNPNKRIT VEEALAHPYL EQYYDPTDEP VAEEPFTFAM 350
ELDDLPKERL KELIFQETAR FQPGVLEAP

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