MAPK1 is a predicted scaffold protein, which is related to the following pathway(s).

MAP2K1->MAPK1->DUSP1
MAP2K1->MAPK1->DUSP16
MAP2K1->MAPK1->DUSP6
MAP2K1->MAPK1->MAPKAPK5
MAP2K1->MAPK1->MBP
MAP2K1->MAPK1->NFATC4
MAP2K1->MAPK1->PLA2G4A
MAP2K1->MAPK1->SMAD3
MAP2K1->MAPK1->EGFR->GRB2
MAP2K1->MAPK1->EGFR->STAT1
MAP2K1->MAPK1->MAPKAPK2->CDC25B
MAP2K1->MAPK1->MAPKAPK2->CREB1
MAP2K1->MAPK1->MAPKAPK2->EEF2K
MAP2K1->MAPK1->MAPKAPK2->ESR1
MAPK1->MAP2K1->MAPK3->DUSP1
MAPK1->MAP2K1->MAPK3->DUSP6
MAPK1->MAP2K1->MAPK3->ELK1
MAPK1->MAP2K1->MAPK3->ESR1
MAPK1->MAP2K1->MAPK3->MBP
MAPK1->MAP2K1->MAPK3->MKNK1
MAPK1->MAP2K1->MAPK3->NFATC4
MAPK1->MAP2K1->MAPK3->EGFR->GRB2
MAPK1->MAP2K1->MAPK3->EGFR->STAT1


MAPK1 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PAK1RAF1->MAP2K1->MAPK1->MBP
PAK1RAF1->MAP2K1->MAPK1->SMAD1
PAK1RAF1->MAP2K1->MAPK1->EGFR->GRB2
PAK1RAF1->MAP2K1->MAPK1->EGFR->HGS
PAK1RAF1->MAP2K1->MAPK1->EGFR->PLCG1
GRB10SRC->RAF1->MAP2K1->MAPK1->EGFR
PECAM1MAPK1->LCK->PTPN6
PTPN1MAPK1->CAPN2
PTPN1MAPK1->STAT5A
PTPN1MAPK1->EGFR->GRB2
PTPN1MAPK1->EGFR->STAT5B
PTPN1MAPK1->GSK3B->ESR1
PRKCZMAPK1->MAP2K1->GSK3B->PSEN1
PRKCZMAPK1->MAP2K1->GSK3B->RELA
PRKCZMAPK1->MAP2K1->MAPK3->CASP9
PRKCZMAPK1->MAP2K1->MAPK3->IRS1
PRKCZMAPK1->MAP2K1->MAPK3->MBP
PRKCZMAPK1->MAP2K1->MAPK3->GSK3B->PSEN1
PRKCZMAPK1->MAP2K1->MAPK3->GSK3B->RELA
PRKCZSRC->RAF1->MAP2K1->MAPK1->CASP9
PRKCZSRC->RAF1->MAP2K1->MAPK1->MBP
PRKCZSRC->RAF1->MAP2K1->MAPK1->RELA
PRKCZSRC->RAF1->MAP2K1->MAPK1->GSK3B->PSEN1
PRKCZSRC->RAF1->MAP2K1->MAPK1->GSK3B->RELA
KRT8P9MAPK1->EGFR->ANXA1
DUSP3MAPK1->EGFR->STAT1
SHC1MAPK1->EGFR->CBL
SHC1MAPK1->EGFR->CRK
SHC1MAPK1->EGFR->GAB1
SHC1MAPK1->EGFR->GRB2
SHC1MAPK1->EGFR->PLCG1
SHC1MAPK1->EGFR->RASA1
SHC1MAPK1->EGFR->STAT5B
SHC1MAPK1->LCK->CBL
SHC1MAPK1->LCK->ESR1
SHC1MAPK1->LCK->IL2RB
SHC1MAPK1->LCK->PLCG2
SHC1MAPK1->LCK->PTPN6
SHC1MAPK1->MAPKAPK2->ESR1
SHC1MAPK1->LCK->ZAP70->GAB2
SHC1MAPK1->LCK->ZAP70->LCP2
ELK1MAP2K1->MAPK1->FOS
ELK1MAP2K1->MAPK1->GRB10
ELK1MAPK1->MAP2K1->MAPK3->CEBPB
ELK1MAPK1->MAP2K1->MAPK3->FOS
ELK1MAPK1->MAP2K1->MAPK3->GRB10
PLK3MAP2K1->MAPK1
PLK3MAPK1->MAP2K1
EGFRMAP2K1->MAPK1->PAK1->ESR1
EGFRPAK1->MAP2K1->MAPK1->GAB1
EGFRPAK1->MAP2K1->MAPK1->GRB10
EGFRPAK1->MAP2K1->MAPK1->SOS1
EGFRPAK1->MAP2K1->MAPK1->STAT5A
RPS6KA4MAP2K1->MAPK1->FOS
RPS6KA4MAPK1->MAP2K1->MAPK3->FOS
STAT5BMAPK1->EGFR->CBL
STAT5BMAPK1->EGFR->CRK
STAT5BMAPK1->EGFR->PTPN1
STAT5BMAPK1->EGFR->STAT1
CAV1MAPK1->EGFR->PTPN1
MAP2K1IP1MAP2K1->MAPK1
MAP2K1IP1MAPK1->MAP2K1->MAPK3
STAT5AMAPK1->EGFR->CBL
STAT5AMAPK1->EGFR->CRK
STAT5AMAPK1->EGFR->PTPN1
STAT5AMAPK1->EGFR->STAT1
STAT5AMAPK1->EGFR->STAT5B
STAT5AMAPK1->LCK->CBL
STAT5AMAPK1->LCK->ESR1
STAT5AMAPK1->LCK->IL2RB
STAT5AMAPK1->LCK->SHC1
PTPRHMAPK1->LCK
MAPK14MAP2K1->MAPK1->DUSP1
MAPK14MAP2K1->MAPK1->DUSP16
MAPK14MAP2K1->MAPK1->DUSP6
MAPK14MAP2K1->MAPK1->MAPKAPK5
MAPK14MAP2K1->MAPK1->MBP
MAPK14MAP2K1->MAPK1->NFATC4
MAPK14MAP2K1->MAPK1->PLA2G4A
MAPK14MAP2K1->MAPK1->SMAD3
MAPK14MAP2K1->MAPK1->EGFR->GRB2
MAPK14MAP2K1->MAPK1->EGFR->STAT1
MAPK14MAP2K1->MAPK1->MAPKAPK2->CDC25B
MAPK14MAP2K1->MAPK1->MAPKAPK2->CREB1
MAPK14MAP2K1->MAPK1->MAPKAPK2->EEF2K
MAPK14MAP2K1->MAPK1->MAPKAPK2->ESR1
MAPK14MAPK1->MAP2K1->MAPK3->DUSP1
MAPK14MAPK1->MAP2K1->MAPK3->DUSP6
MAPK14MAPK1->MAP2K1->MAPK3->ELK1
MAPK14MAPK1->MAP2K1->MAPK3->ESR1
MAPK14MAPK1->MAP2K1->MAPK3->MBP
MAPK14MAPK1->MAP2K1->MAPK3->MKNK1
MAPK14MAPK1->MAP2K1->MAPK3->NFATC4
MAPK14MAPK1->MAP2K1->MAPK3->EGFR->GRB2
MAPK14MAPK1->MAP2K1->MAPK3->EGFR->STAT1
RAF1MAP2K1->MAPK1->PAK1->BRAF
RAF1MAPK1->MAP2K1->MAPK3->GRB10
RAF1PAK1->MAP2K1->MAPK1->GRB10
RAF1PAK1->MAP2K1->MAPK1->MYC
RAF1MAPK1->MAP2K1->MAPK3->LCK->IL2RB
RAF1MAPK1->MAP2K1->MAPK3->LCK->VAV1
RAF1MAPK1->PAK1->MAP2K1->MAPK3->GRB10
RAF1PAK1->MAP2K1->MAPK1->LCK->IL2RB
RAF1PAK1->MAP2K1->MAPK1->LCK->VAV1
RAF1MAPK1->PAK1->MAP2K1->MAPK3->LCK->IL2RB
RAF1MAPK1->PAK1->MAP2K1->MAPK3->LCK->VAV1
CASP9MAP2K1->MAPK1->CAPN2
CASP9MAPK1->MAP2K1->MAPK3->CAPN2
IFNAR1MAPK1->LCK->PTPN6
IFNAR1MAPK1->LCK->ZAP70
KSR2MAP3K8->MAP2K1->MAPK1
KSR2MAPK1->MAP2K1->MAPK3
KSR2RAF1->MAP2K1->MAPK1
MAP2K1MAPK1->PAK1->BRAF
MAP2K1MAPK1->PAK1->FLNA
MAP2K1MAPK1->PAK1->RAF1
KHDRBS1MAPK1->LCK->CBL
KHDRBS1MAPK1->LCK->ITK
KHDRBS1MAPK1->LCK->PLCG2
KHDRBS1MAPK1->LCK->PTPN6
GAB1MAPK1->EGFR->CRK
GAB1MAPK1->EGFR->GRB2
GAB1MAPK1->EGFR->PLCG1
PBPMAPK1->MAP2K1
PBPRAF1->MAP2K1->MAPK1
GAB2MAPK1->EGFR->GRB2
GAB2MAPK1->LCK->PLCG2
GAB2MAPK1->LCK->PTPN6
GAB2MAPK1->LCK->SHC1
GAB2MAPK1->LCK->ZAP70->SHC1
BRAFMAPK1->MAP2K1->MAPK3
BRAFRAF1->MAP2K1->MAPK1
PEBP1RAF1->MAP2K1->MAPK1
VAV1RAF1->MAP2K1->MAPK1->EGFR->CBL
VAV1RAF1->MAP2K1->MAPK1->EGFR->CRK
VAV1RAF1->MAP2K1->MAPK1->EGFR->GRB2
VAV1RAF1->MAP2K1->MAPK1->EGFR->PLCG1
VAV1RAF1->MAP2K1->MAPK1->LCK->CBL
VAV1RAF1->MAP2K1->MAPK1->LCK->PRKCQ
VAV1RAF1->MAP2K1->MAPK1->LCK->PTPN6
VAV1RAF1->MAP2K1->MAPK1->LCK->ZAP70->LCP2
RPS6KA2MAPK1->MAP2K1->MAPK3
DYRK1BMAPK1->MBP


The sequence of MAPK1

Amino acids in red are phosphorylation sites determined by MS/MS

MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR 50
VAIKKISPFE HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD 100
VYIVQDLMET DLYKLLKTQH LSNDHICYFL YQILRGLKYI HSANVLHRDL 150
KPSNLLLNTT CDLKICDFGL ARVADPDHDH TGFLTEYVAT RWYRAPEIML 200
NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE 250
DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK 300
RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE 350
TARFQPGYRS

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