LYN is a predicted scaffold protein, which is related to the following pathway(s).

CSK->SRC->EGFR->CBL
CSK->SRC->EGFR->MUC1
CSK->SRC->EGFR->PLCG1
CSK->SRC->EGFR->RASA1
CSK->SRC->EGFR->RGS16


LYN is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PLCG2LYN->BTK->TEC
PLCG2LYN->BTK->ITK->TEC
SHC1CSK->LYN->EPOR
SHC1CSK->LYN->FCGR2A
SHC1CSK->LYN->PLCG2
SHC1CSK->LYN->STAT5A
LIME1LYN->PLCG2
PLCG1LYN->BTK->TEC
PLCG1LYN->BTK->WAS
PLCG1LYN->BTK->ITK->CD28
PLCG1LYN->BTK->ITK->TEC
CBLCSK->LYN->CD19
CBLCSK->LYN->EPOR
CBLCSK->LYN->STAT5A
CBLCSK->LYN->BTK->ITK
DOK3CSK->LYN
PTK2CSK->LYN->CD79B
PPP1R8LYN->CSNK2A1->HDAC2
PPP1R8LYN->CSNK2A1->STC2
CD19LYN->BTK->PLCG2
DAPP1LYN->PLCG2
DAPP1LYN->BTK->PLCG2
TECLYN->BTK->BMX
TECLYN->BTK->PLCG2
TECLYN->BTK->WAS
GP6LYN->FCGR2A
LY6G5BLYN->CSNK2A1->CDC25B
LY6G5BLYN->CSNK2A1->CDC34
LY6G5BLYN->CSNK2A1->EIF5
LY6G5BLYN->CSNK2A1->FAF1
LY6G5BLYN->CSNK2A1->RNF7
LY6G5BLYN->CSNK2A1->CDC2->CDC25B
KITLYN->BTK->TEC
CSNK2BLYN->CSNK2A1->CDC34
CSNK2BLYN->CSNK2A1->FAF1
CSNK2BLYN->CSNK2A1->RNF7
CSNK2BLYN->CSNK2A1->RNPS1
FCER1GLYN->PLCG2
FCER1GLYN->BTK->PLCG2
KHDRBS1LYN->BTK->ITK
KHDRBS1LYN->BTK->PLCG2
RPS6KB2LYN->BTK
GAB2LYN->EPOR
GAB2LYN->PLCG2
HCLS1LYN->CSNK2A1->WAS
RPS6KB1LYN->CSNK2A1->AKT1
RPS6KB1LYN->CSNK2A1->MAPK9
RPS6KB1LYN->CSNK2A1->CDC2->CSNK2B


The sequence of LYN

Amino acids in red are phosphorylation sites determined by MS/MS

MGCIKSKGKD SLSDDGVDLK TQPVRNTERT IYVRDPTSNK QQRPVPESQL 50
LPGQRFQTKD PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW 100
KAKSLLTKKE GFIPSNYVAK LNTLETEEWF FKDITRKDAE RQLLAPGNSA 150
GAFLIRESET LKGSFSLSVR DFDPVHGDVI KHYKIRSLDN GGYYISPRIT 200
FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW EIPRESIKLV 250
KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 300
KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ 350
IAEGMAYIER KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR 400
EGAKFPIKWT APEAINFGCF TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA 450
DVMTALSQGY RMPRVENCPD ELYDIMKMCW KEKAEERPTF DYLQSVLDDF 500
YTATEGQYQQ QP

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