LCP2 is a predicted scaffold protein, which is related to the following pathway(s).

LCK->ZAP70->SHC1



LCP2 is a known scaffold protein, which is related to the following pathway(s).

GRAP2->LAT

Reference:Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT.

PMID:10224278


LCP2 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
BLNKSYK->MAP4K1->LCP2
SHC1SYK->MAP4K1->LCP2
SHC1MAPK1->LCK->ZAP70->LCP2
PLCG1LCK->ZAP70->LCP2
CBLLCK->ZAP70->LCP2
LATLCK->ZAP70->LCP2
LATSYK->MAP4K1->LCP2
PAG1LCK->ZAP70->LCP2
PTPN6LCK->ZAP70->LCP2
VAV1RAF1->MAP2K1->MAPK1->LCK->ZAP70->LCP2


The sequence of LCP2

Amino acids in red are phosphorylation sites determined by MS/MS

MALRNVPFRS EVLGWDPDSL ADYFKKLNYK DCEKAVKKYH IDGARFLNLT 50
ENDIQKFPKL RVPILSKLSQ EINKNEERRS IFTRKPQVPR FPEETESHEE 100
DNGGWSSFEE DDYESPNDDQ DGEDDGDYES PNEEEEAPVE DDADYEPPPS 150
NDEEALQNSI LPAKPFPNSN SMYIDRPPSG KTPQQPPVPP QRPMAALPPP 200
PAGRNHSPLP PPQTNHEEPS RSRNHKTAKL PAPSIDRSTK PPLDRSLAPF 250
DREPFTLGKK PPFSDKPSIP AGRSLGEHLP KIQKPPLPPT TERHERSSPL 300
PGKKPPVPKH GWGPDRREND EDDVHQRPLP QPALLPMSSN TFPSRSTKPS 350
PMNPLPSSHM PGAFSESNSS FPQSASLPPY FSQGPSNRPP IRAEGRNFPL 400
PLPNKPRPPS PAEEENSLNE EWYVSYITRP EAEAALRKIN QDGTFLVRDS 450
SKKTTTNPYV LMVLYKDKVY NIQIRYQKES QVYLLGTGLR GKEDFLSVSD 500
IIDYFRKMPL LLIDGKNRGS RYQCTLTHAA GYP

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