LCK is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PECAM1MAPK1->LCK->PTPN6
PLCG2LCK->ITK->TEC
SHC1MAPK1->LCK->CBL
SHC1MAPK1->LCK->ESR1
SHC1MAPK1->LCK->IL2RB
SHC1MAPK1->LCK->PLCG2
SHC1MAPK1->LCK->PTPN6
SHC1MAPK1->LCK->ZAP70->GAB2
SHC1MAPK1->LCK->ZAP70->LCP2
LIME1LCK->PLCG2
SH3BP2LCK->CBL
SH3BP2LCK->PLCG2
SH3BP2LCK->VAV1
SH3BP2LCK->VAV2
SH3BP2LCK->ZAP70
PTPN11MAPK3->LCK->CBL
PTPN11MAPK3->LCK->CD33
PTPN11MAPK3->LCK->PLCG2
PTPN11MAPK3->LCK->PTPN6
PTPN11MAPK3->LCK->SHC1
PTPN11MAPK3->LCK->SLAMF1
PTPN11MAPK3->LCK->SOCS3
PLCG1LCK->ITK->CD28
PLCG1LCK->ITK->TEC
PLCG1LCK->ZAP70->LCP2
PLCG1LCK->ZAP70->SHC1
CBLLCK->ZAP70->LCP2
CBLLCK->ZAP70->SHC1
LATLCK->ZAP70->GAB2
LATLCK->ZAP70->LCP2
PAG1LCK->ZAP70->LCP2
PAG1LCK->ZAP70->SHC1
DAPP1LCK->PLCG2
CD247LCK->ZAP70->GAB2
CD247LCK->ZAP70->SH2B3
CD247LCK->ZAP70->SHC1
STAT5AMAPK1->LCK->CBL
STAT5AMAPK1->LCK->ESR1
STAT5AMAPK1->LCK->IL2RB
STAT5AMAPK1->LCK->SHC1
STAT5AMAPK3->LCK->CBL
STAT5AMAPK3->LCK->ESR1
STAT5AMAPK3->LCK->IL2RB
STAT5AMAPK3->LCK->SHC1
PTPN6LCK->ZAP70->GAB2
PTPN6LCK->ZAP70->LCP2
PTPN6LCK->ZAP70->SHC1
PTPRHMAPK1->LCK
LCP2LCK->ZAP70->SHC1
RAF1MAP2K2->MAPK3->LCK->IL2RB
RAF1MAP2K2->MAPK3->LCK->VAV1
RAF1MAPK1->MAP2K1->MAPK3->LCK->IL2RB
RAF1MAPK1->MAP2K1->MAPK3->LCK->VAV1
RAF1PAK1->MAP2K1->MAPK1->LCK->IL2RB
RAF1PAK1->MAP2K1->MAPK1->LCK->VAV1
RAF1MAPK1->PAK1->MAP2K1->MAPK3->LCK->IL2RB
RAF1MAPK1->PAK1->MAP2K1->MAPK3->LCK->VAV1
RASA1LCK->ZAP70->SHC1
IFNAR1MAPK1->LCK->PTPN6
IFNAR1MAPK1->LCK->ZAP70
FCGR3ALCK->ZAP70->SHC1
KHDRBS1MAPK1->LCK->CBL
KHDRBS1MAPK1->LCK->ITK
KHDRBS1MAPK1->LCK->PLCG2
KHDRBS1MAPK1->LCK->PTPN6
GAB2MAPK1->LCK->PLCG2
GAB2MAPK1->LCK->PTPN6
GAB2MAPK1->LCK->SHC1
GAB2MAPK3->LCK->PLCG2
GAB2MAPK3->LCK->PTPN6
GAB2MAPK3->LCK->SHC1
GAB2MAPK1->LCK->ZAP70->SHC1
GAB2MAPK3->LCK->ZAP70->SHC1
CD3ELCK->ZAP70->SHC1
VAV1RAF1->MAP2K1->MAPK1->LCK->CBL
VAV1RAF1->MAP2K1->MAPK1->LCK->PRKCQ
VAV1RAF1->MAP2K1->MAPK1->LCK->PTPN6
VAV1RAF1->MAP2K1->MAPK1->LCK->ZAP70->LCP2


The sequence of LCK

Amino acids in red are phosphorylation sites determined by MS/MS

MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT 50
YEGSNPPASP LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA 100
QSLTTGQEGF IPFNFVAKAN SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS 150
FLIRESESTA GSFSLSVRDF DQNQGEVVKH YKIRNLDNGG FYISPRITFP 200
GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV PRETLKLVER 250
LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL 300
VRLYAVVTQE PIYIITEYME NDTLLDSQLE EKGLGASPWG NLGQQLLLLP 350
TGSLVDFLKT PSGIKLTINK LLDMAAQIAE GMAFIEERNY IHRDLRAANI 400
LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 450
SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY 500
QLMRLCWKER PEDRPTFDYL RSVLEDFFTA TEGQYQPQP

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