JAK3 is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
CXCR4JAK3->JAK1->STAT1
CXCR4JAK3->JAK1->STAT3
PRMT5JAK3->JAK1->TYK2
STAT5BJAK3->JAK1->STAT1
STAT5BJAK3->JAK1->STAT3
STAT5AJAK3->JAK1->STAT1
STAT5AJAK3->JAK1->STAT3
PTPN6JAK3->JAK1->TYK2->IFNAR1
PTPN2JAK3->JAK1->STAT1
PTPN2JAK3->JAK1->STAT3
IL7RJAK3->JAK1->STAT3
SKB1JAK3->JAK1->TYK2
STAM2JAK3->JAK1->TYK2
PIK3R1JAK3->JAK1->TYK2->IFNAR1
IL2RBJAK3->JAK1->STAT1
IL2RBJAK3->JAK1->STAT3
PTPRCJAK3->JAK1->TYK2->IFNAR1
IL2RGJAK3->JAK1->STAT1


The sequence of JAK3

Amino acids in red are phosphorylation sites determined by MS/MS

MAPPSEETPL IPQRSCSLLS TEAGALHVLL PARGPGPPQR LSFSFGDHLA 50
EDLCVQAAKA SGILPVYHSL FALATEDLSC WFPPSHIFSV EDASTQVLLY 100
RIRFYFPNWF GLEKCHRFGL RKDLASAILD LPVLEHLFAQ HRSDLVSGRL 150
PVGLSLKEQG ECLSLAVLDL ARMAREQAQR PGELLKTVSY KACLPPSLRD 200
LIQGLSFVTR RRIRRTVRRA LRRVAACQAD RHSLMAKYIM DLERLDPAGA 250
AETFHVGLPG ALGGHDGLGL LRVAGDGGIA WTQGEQEVLQ PFCDFPEIVD 300
ISIKQAPRVG PAGEHRLVTV TRTDNQILEA EFPGLPEALS FVALVDGYFR 350
LTTDSQHFFC KEVAPPRLLE EVAEQCHGPI TLDFAINKLK TGGSRPGSYV 400
LRRSPQDFDS FLLTVCVQNP LGPDYKGCLI RRSPTGTFLL VGLSRPHSSL 450
RELLATCWDG GLHVDGVAVT LTSCCIPRPK EKSNLIVVQR GHSPPTSSLV 500
QPQSQYQLSQ MTFHKIPADS LEWHENLGHG SFTKIYRGCR HEVVDGEARK 550
TEVLLKVMDA KHKNCMESFL EAASLMSQVS YRHLVLLHGV CMAGDSTMVQ 600
EFVHLGAIDM YLRKRGHLVP ASWKLQVVKQ LAYALNYLED KGLPHGNVSA 650
RKVLLAREGA DGSPPFIKLS DPGVSPAVLS LEMLTDRIPW VAPECLREAQ 700
TLSLEADKWG FGATVWEVFS GVTMPISALD PAKKLQFYED RQQLPAPKWT 750
ELALLIQQCM AYEPVQRPSF RAVIRDLNSL ISSDYELLSD PTPGALAPRD 800
GLWNGAQLYA CQDPTIFEER HLKYISQLGK GNFGSVELCR YDPLGDNTGA 850
LVAVKQLQHS GPDQQRDFQR EIQILKALHS DFIVKYRGVS YGPGRQSLRL 900
VMEYLPSGCL RDFLQRHRAR LDASRLLLYS SQICKGMEYL GSRRCVHRDL 950
AARNILVESE AHVKIADFGL AKLLPLDKDY YVVREPGQSP IFWYAPESLS 1000
DNIFSRQSDV WSFGVVLYEL FTYCDKSCSP SAEFLRMMGC ERDVPALCRL 1050
LELLEEGQRL PAPPACPAEV HELMKLCWAP SPQDRPSFSA LGPQLDMLWS 1100
GSRGCETHAF TAHPEGKHHS LSFS

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