ITK is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PLCG2LCK->ITK->TEC
PLCG2LYN->BTK->ITK->TEC
PLCG1LCK->ITK->CD28
PLCG1LCK->ITK->TEC
PLCG1LYN->BTK->ITK->CD28
PLCG1LYN->BTK->ITK->TEC
PLCG1PDGFRA->SRC->ABL1->BTK->ITK->CD28
PLCG1PDGFRA->SRC->ABL1->BTK->ITK->TEC
CBLCSK->LYN->BTK->ITK
CBLCSK->SRC->ABL1->BTK->ITK
CBLPDGFRA->SRC->ABL1->BTK->ITK
BTKITK->TEC->BMX
BMXBTK->ITK->TEC
WASBTK->ITK->TEC
KHDRBS1LYN->BTK->ITK
KHDRBS1MAPK1->LCK->ITK


The sequence of ITK

Amino acids in red are phosphorylation sites determined by MS/MS

MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT 50
LKGSIELSRI KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ 100
RWVLALKEET RNNNSLVPKY HPNFWMDGKW RCCSQLEKLA TGCAQYDPTK 150
NASKKPLPPT PEDNRRPLWE PEETVVIALY DYQTNDPQEL ALRRNEEYCL 200
LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLETYEWY NKSISRDKAE 250
KLLLDTGKEG AFMVRDSRTA GTYTVSVFTK AVVSENNPCI KHYHIKETND 300
NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCF GRQKAPVTAG 350
LRYGKWVIDP SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIREGAMSE 400
EDFIEEAEVM MKLSHPKLVQ LYGVCLEQAP ICLVFEFMEH GCLSDYLRTQ 450
RGLFAAETLL GMCLDVCEGM AYLEEACVIH RDLAARNCLV GENQVIKVSD 500
FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD VWSFGVLMWE 550
VFSEGKIPYE NRSNSEVVED ISTGFRLYKP RLASTHVYQI MNHCWKERPE 600
DRPAFSRLLR QLAEIAESGL

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