| CSK | -> | SRC | -> | CAV1 | CSK | -> | SRC | -> | CBL | CSK | -> | SRC | -> | GNB2L1 | CSK | -> | SRC | -> | GRB10 | CSK | -> | SRC | -> | PIK3R1 | CSK | -> | SRC | -> | PTK2 | CSK | -> | SRC | -> | PTPN6 | CSK | -> | SRC | -> | RAF1 | CSK | -> | SRC | -> | SHC1 | CSK | -> | SRC | -> | STAT5A | CSK | -> | SRC | -> | STAT5B | CSK | -> | SRC | -> | IGF1R | -> | ADRB2 | CSK | -> | SRC | -> | IGF1R | -> | CRK |
| Scaffold Protein(s) | Related Pathway(s) | SHC1 | SYK->PRKCA->INSR->CBL | SHC1 | SYK->PRKCA->INSR->DOK1 | SHC1 | SYK->PRKCA->INSR->GAB1 | SHC1 | SYK->PRKCA->INSR->PIK3R1 | PTPN11 | PRKCA->INSR->CBL | PTPN11 | PRKCA->INSR->GAB1 | PTPN11 | PRKCA->INSR->PIK3R1 | PTPN11 | PRKCA->INSR->SHC1 | CBL | SYK->PRKCA->INSR->PIK3R1 | CBL | SYK->PRKCA->INSR->SHC1 | PTPN6 | SYK->PRKCA->INSR->CBL | PTPN6 | SYK->PRKCA->INSR->DOK1 | PTPN6 | SYK->PRKCA->INSR->PIK3R1 | PTPN6 | SYK->PRKCA->INSR->SHC1 | PTPN2 | INSR->SHC1 | CEACAM1 | INSR->SHC1 |
|---|
The sequence of INSR
Amino acids in red are phosphorylation sites determined by MS/MS
MATGGRRGAA AAPLLVAVAA LLLGAAGHLY PGEVCPGMDI RNNLTRLHEL 50
ENCSVIEGHL QILLMFKTRP EDFRDLSFPK LIMITDYLLL FRVYGLESLK 100
DLFPNLTVIR GSRLFFNYAL VIFEMVHLKE LGLYNLMNIT RGSVRIEKNN 150
ELCYLATIDW SRILDSVEDN YIVLNKDDNE ECGDICPGTA KGKTNCPATV 200
INGQFVERCW THSHCQKVCP TICKSHGCTA EGLCCHSECL GNCSQPDDPT 250
KCVACRNFYL DGRCVETCPP PYYHFQDWRC VNFSFCQDLH HKCKNSRRQG 300
CHQYVIHNNK CIPECPSGYT MNSSNLLCTP CLGPCPKVCH LLEGEKTIDS 350
VTSAQELRGC TVINGSLIIN IRGGNNLAAE LEANLGLIEE ISGYLKIRRS 400
YALVSLSFFR KLRLIRGETL EIGNYSFYAL DNQNLRQLWD WSKHNLTITQ 450
GKLFFHYNPK LCLSEIHKME EVSGTKGRQE RNDIALKTNG DQASCENELL 500
KFSYIRTSFD KILLRWEPYW PPDFRDLLGF MLFYKEAPYQ NVTEFDGQDA 550
CGSNSWTVVD IDPPLRSNDP KSQNHPGWLM RGLKPWTQYA IFVKTLVTFS 600
DERRTYGAKS DIIYVQTDAT NPSVPLDPIS VSNSSSQIIL KWKPPSDPNG 650
NITHYLVFWE RQAEDSELFE LDYCLKGLKL PSRTWSPPFE SEDSQKHNQS 700
EYEDSAGECC SCPKTDSQIL KELEESSFRK TFEDYLHNVV FVPRKTSSGT 750
GAEDPRPSRK RRSLGDVGNV TVAVPTVAAF PNTSSTSVPT SPEEHRPFEK 800
VVNKESLVIS GLRHFTGYRI ELQACNQDTP EERCSVAAYV SARTMPEAKA 850
DDIVGPVTHE IFENNVVHLM WQEPKEPNGL IVLYEVSYRR YGDEELHLCV 900
SRKHFALERG CRLRGLSPGN YSVRIRATSL AGNGSWTEPT YFYVTDYLDV 950
PSNIAKIIIG PLIFVFLFSV VIGSIYLFLR KRQPDGPLGP LYASSNPEYL 1000
SASDVFPCSV YVPDEWEVSR EKITLLRELG QGSFGMVYEG NARDIIKGEA 1050
ETRVAVKTVN ESASLRERIE FLNEASVMKG FTCHHVVRLL GVVSKGQPTL 1100
VVMELMAHGD LKSYLRSLRP EAENNPGRPP PTLQEMIQMA AEIADGMAYL 1150
NAKKFVHRDL AARNCMVAHD FTVKIGDFGM TRDIYETDYY RKGGKGLLPV 1200
RWMAPESLKD GVFTTSSDMW SFGVVLWEIT SLAEQPYQGL SNEQVLKFVM 1250
DGGYLDQPDN CPERVTDLMR MCWQFNPKMR PTFLEIVNLL KDDLHPSFPE 1300
VSFFHSEENK APESEELEME FEDMENVPLD RSSHCQREEA GGRDGGSSLG 1350
FKRSYEEHIP YTHMNGGKKN GRILTLPRSN PS