IGF1R is a predicted scaffold protein, which is related to the following pathway(s).

CSK->SRC->ESR1
CSK->SRC->GNB2L1
CSK->SRC->GRB10
CSK->SRC->PIK3R1
CSK->SRC->PXN
CSK->SRC->SHC1
CSK->SRC->STAT3
CSK->SRC->EGFR->CRK
CSK->SRC->EGFR->PTPN1
CSK->SRC->EGFR->RASA1
CSK->SRC->PTK2->PXN


IGF1R is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PTPN1SRC->IGF1R
SHC1CSK->SRC->IGF1R->CRK
PTPN11PDGFRA->SRC->IGF1R
EGFRCSK->SRC->IGF1R->CRK
PTK2CSK->SRC->IGF1R->CRK
DOK4SRC->IGF1R->CRK
CSKSRC->IGF1R->ADRB2
PXNCSK->SRC->IGF1R->CRK
INSRCSK->SRC->IGF1R->ADRB2
INSRCSK->SRC->IGF1R->CRK
CRKPDGFRA->SRC->IGF1R
RASA1CSK->SRC->IGF1R
PIK3R1PDGFRA->SRC->IGF1R->CRK


The sequence of IGF1R

Amino acids in red are phosphorylation sites determined by MS/MS

MKSGSGGGSP TSLWGLLFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE 50
NCTVIEGYLH ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF 100
PNLTVIRGWK LFYNYALVIF EMTNLKDIGL YNLRNITRGA IRIEKNADLC 150
YLSTVDWSLI LDAVSNNYIV GNKPPKECGD LCPGTMEEKP MCEKTTINNE 200
YNYRCWTTNR CQKMCPSTCG KRACTENNEC CHPECLGSCS APDNDTACVA 250
CRHYYYAGVC VPACPPNTYR FEGWRCVDRD FCANILSAES SDSEGFVIHD 300
GECMQECPSG FIRNGSQSMY CIPCEGPCPK VCEEEKKTKT IDSVTSAQML 350
QGCTIFKGNL LINIRRGNNI ASELENFMGL IEVVTGYVKI RHSHALVSLS 400
FLKNLRLILG EEQLEGNYSF YVLDNQNLQQ LWDWDHRNLT IKAGKMYFAF 450
NPKLCVSEIY RMEEVTGTKG RQSKGDINTR NNGERASCES DVLHFTSTTT 500
SKNRIIITWH RYRPPDYRDL ISFTVYYKEA PFKNVTEYDG QDACGSNSWN 550
MVDVDLPPNK DVEPGILLHG LKPWTQYAVY VKAVTLTMVE NDHIRGAKSE 600
ILYIRTNASV PSIPLDVLSA SNSSSQLIVK WNPPSLPNGN LSYYIVRWQR 650
QPQDGYLYRH NYCSKDKIPI RKYADGTIDI EEVTENPKTE VCGGEKGPCC 700
ACPKTEAEKQ AEKEEAEYRK VFENFLHNSI FVPRPERKRR DVMQVANTTM 750
SSRSRNTTAA DTYNITDPEE LETEYPFFES RVDNKERTVI SNLRPFTLYR 800
IDIHSCNHEA EKLGCSASNF VFARTMPAEG ADDIPGPVTW EPRPENSIFL 850
KWPEPENPNG LILMYEIKYG SQVEDQRECV SRQEYRKYGG AKLNRLNPGN 900
YTARIQATSL SGNGSWTDPV FFYVQAKTGY ENFIHLIIAL PVAVLLIVGG 950
LVIMLYVFHR KRNNSRLGNG VLYASVNPEY FSAADVYVPD EWEVAREKIT 1000
MSRELGQGSF GMVYEGVAKG VVKDEPETRV AIKTVNEAAS MRERIEFLNE 1050
ASVMKEFNCH HVVRLLGVVS QGQPTLVIME LMTRGDLKSY LRSLRPEMEN 1100
NPVLAPPSLS KMIQMAGEIA DGMAYLNANK FVHRDLAARN CMVAEDFTVK 1150
IGDFGMTRDI YETDYYRKGG KGLLPVRWMS PESLKDGVFT TYSDVWSFGV 1200
VLWEIATLAE QPYQGLSNEQ VLRFVMEGGL LDKPDNCPDM LFELMRMCWQ 1250
YNPKMRPSFL EIISSIKEEM EPGFREVSFY YSEENKLPEP EELDLEPENM 1300
ESVPLDPSAS SSSLPLPDRH SGHKAENGPG PGVLVLRASF DERQPYAHMN 1350
GGRKNERALP LPQSSTC

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