HGS is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PAK1RAF1->MAP2K1->MAPK1->EGFR->HGS
METSRC->EGFR->HGS
KRT18P19CDC2->EGFR->HGS
KRT18P19PRKCA->EGFR->HGS
PIK3R1PDGFRA->SRC->EGFR->HGS


The sequence of HGS

Amino acids in red are phosphorylation sites determined by MS/MS

MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK 50
KKVNDKNPHV ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV 100
EVNVRNKILY LIQAWAHAFR NEPKYKVVQD TYQIMKVEGH VFPEFKESDA 150
MFAAERAPDW VDAEECHRCR VQFGVMTRKH HCRACGQIFC GKCSSKYSTI 200
PKFGIEKEVR VCEPCYEQLN RKAEGKATST TELPPEYLTS PLSQQSQLPP 250
KRDETALQEE EELQLALALS QSEAEEKERL RQKSTYTSYP KAEPMPSASS 300
APPASSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA 350
PVPLTEPAAQ PGEGHAAPTN VVENPLPETD SQPIPPSGGP FSEPQFHNGE 400
SEESHEQFLK ALQNAVTTFV NRMKSNHMRG RSITNDSAVL SLFQSINGMH 450
PQLLELLNQL DERRLYYEGL QDKLAQIRDA RGALSALREE HREKLRRAAE 500
EAERQRQIQL AQKLEIMRQK KQEYLEVQRQ LAIQRLQEQE KERQMRLEQQ 550
KQTVQMRAQM PAFPLPYAQL QAMPAAGGVL YQPSGPASFP STFSPAGSVE 600
GSPMHGVYMS QPAPAAGPYP SMPSTAADPS MVSAYMYPAG ATGAQAAPQA 650
QAGPTASPAY SSYQPTPTAG YQNVASQAPQ SLPAISQPPQ SSTMGYMGSQ 700
SVSMGYQPYN MQNLMTTLPS QDASLPPQQP YIAGQQPMYQ QMAPSGGPPQ 750
QQPPVAQQPQ AQGPPAQGSE AQLISFD

Home