GRB2 is a predicted scaffold protein, which is related to the following pathway(s).

GRB2 is a known scaffold protein, which is related to the following pathway(s).

PTPN12

->

SHC

->

SHIP

Reference:PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates.

PMID:11432829

GRB2 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)	Related Pathway(s)
PAK1	RAF1->MAP2K1->MAPK1->EGFR->GRB2
PTPN1	MAPK1->EGFR->GRB2
PTPN1	SRC->EGFR->GRB2
PTPN1	CSNK2A1->CDC2->EGFR->GRB2
MET	SRC->EGFR->GRB2
SHC1	MAPK1->EGFR->GRB2
SHC1	CSK->SRC->EGFR->GRB2
SHC1	SYK->PRKCA->EGFR->GRB2
PTPN11	MAPK3->EGFR->GRB2
PTPN11	PRKCA->EGFR->GRB2
PTPN11	PDGFRA->SRC->EGFR->GRB2
PLCG1	PDGFRA->SRC->EGFR->GRB2
CBL	CSK->SRC->EGFR->GRB2
CBL	PDGFRA->SRC->EGFR->GRB2
CBL	SYK->PRKCA->EGFR->GRB2
PLEC1	CDC2->EGFR->GRB2
PTK2	CSK->SRC->EGFR->GRB2
MUC1	SRC->EGFR->GRB2
PTPN6	SRC->EGFR->GRB2
PTPN6	SYK->PRKCA->EGFR->GRB2
MAPK14	MAP2K1->MAPK1->EGFR->GRB2
MAPK14	MAPK1->MAP2K1->MAPK3->EGFR->GRB2
PDGFRB	PDGFRA->SRC->EGFR->GRB2
PXN	CSK->SRC->EGFR->GRB2
CRK	PDGFRA->SRC->EGFR->GRB2
RASA1	CSK->SRC->EGFR->GRB2
PIK3R1	PDGFRA->SRC->EGFR->GRB2
BCAR1	SRC->EGFR->GRB2
WAS	SRC->EGFR->GRB2
CBLC	SRC->EGFR->GRB2
GAB1	MAPK1->EGFR->GRB2
GAB1	MAPK3->EGFR->GRB2
GAB2	MAPK1->EGFR->GRB2
GAB2	MAPK3->EGFR->GRB2
GAB2	SRC->EGFR->GRB2
VAV1	RAF1->MAP2K1->MAPK1->EGFR->GRB2

GRB2 is also a known signal protein, which is involved in the following pathway(s)

Scaffold Protein(s)	Related Pathway(s)	PMID
FRS2	FGFR->GRB2->SHP2	10809663
GAB1	GRB2->SOS	16687399
IRS1	GRB2->SHC	The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc
PTPN12	SHC->SHIP->GRB2	11432829
SHC1	GRB2->PTPN12	23846654

Reference:Protein-protein interactions define specificity in signal transduction.

PMID:10809663

Reference:Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops.

PMID:16687399

Reference: implications for insulin control of ras signalling.

PMID:The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc

Reference:PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates.

PMID:11432829

Reference:Temporal regulation of EGF signalling networks by the scaffold protein Shc1.

PMID:23846654

The sequence of GRB2

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