GRB10 is a predicted scaffold protein, which is related to the following pathway(s).

SRC->ABL1->BCR
SRC->RAF1->MAP2K1->MAPK1->EGFR


GRB10 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
ELK1MAP2K1->MAPK1->GRB10
ELK1MAPK1->MAP2K1->MAPK3->GRB10
EGFRPAK1->MAP2K1->MAPK1->GRB10
DOK1CSK->FYN->GRB10
DOK1CSK->SRC->GRB10
IGF1RCSK->SRC->GRB10
SRCSYK->PRKCA->ADRBK1->PDGFRB->FYN->GRB10
PDGFRBPDGFRA->SRC->GRB10
INSRCSK->SRC->GRB10
RAF1MAPK1->MAP2K1->MAPK3->GRB10
RAF1PAK1->MAP2K1->MAPK1->GRB10
RAF1MAPK1->PAK1->MAP2K1->MAPK3->GRB10


The sequence of GRB10

Amino acids in red are phosphorylation sites determined by MS/MS

MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV 50
DLEALVNDMN ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ 100
PQVSPRQRVQ RSQPVHILAV RRLQEEDQQF RTSSLPAIPN PFPELCGPGS 150
PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK VVEILADMTA RDLCQLLVYK 200
SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE SKFLFRKNYA 250
KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK 300
ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG 350
RKQYNAPTDH GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG 400
MLLYQNYRIP QQRKALLSPF STPVRSVSEN SLVAMDFSGQ TGRVIENPAE 450
AQSAALEEGH AWRKRSTRMN ILGSQSPLHP STLSTVIHRT QHWFHGRISR 500
EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK NFQILPCEDD 550
GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL 600

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