GAB2 is a predicted scaffold protein, which is related to the following pathway(s).

LYN->EPOR
LYN->PLCG2
MAPK3->ETV6
SRC->PIK3R1
SRC->PLCG2
SRC->PTPN6
SRC->SHC1
SYK->SHC1
MAPK1->EGFR->GRB2
MAPK1->LCK->PLCG2
MAPK1->LCK->PTPN6
MAPK1->LCK->SHC1
MAPK3->EGFR->GRB2
MAPK3->LCK->PLCG2
MAPK3->LCK->PTPN6
MAPK3->LCK->SHC1
SRC->EGFR->GRB2
MAPK1->LCK->ZAP70->SHC1
MAPK3->LCK->ZAP70->SHC1



GAB2 is a known scaffold protein, which is related to the following pathway(s).

SHP2->P85

Reference:Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase.

PMID:11287610


GAB2 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
SHC1MAPK1->LCK->ZAP70->GAB2
LATLCK->ZAP70->GAB2
CD247LCK->ZAP70->GAB2
PTPN6LCK->ZAP70->GAB2


The sequence of GAB2

Amino acids in red are phosphorylation sites determined by MS/MS

MSGGGDVVCT GWLRKSPPEK KLRRYAWKKR WFILRSGRMS GDPDVLEYYK 50
NDHSKKPLRI INLNFCEQVD AGLTFNKKEL QDSFVFDIKT SERTFYLVAE 100
TEEDMNKWVQ SICQICGFNQ AEESTDSLRN VSSAGHGPRS SPAELSSSSQ 150
HLLRERKSSA PSHSSQPTLF TFEPPVSNHM QPTLSTSAPQ EYLYLHQCIS 200
RRAENARSAS FSQGTRASFL MRSDTAVQKL AQGNGHCVNG ISGQVHGFYS 250
LPKPSRHNTE FRDSTYDLPR SLASHGHTKG SLTGSETDNE DVYTFKTPSN 300
TLCREFGDLL VDNMDVPATP LSAYQIPRTF TLDKNHNAMT VATPGDSAIA 350
PPPRPPKPSQ AETPRWGSPQ QRPPISENSR SVAATIPRRN TLPAMDNSRL 400
HRASSCETYE YPQRGGESAG RSAESMSDGV GSFLPGKMIV GRSDSTNSED 450
NYVPMNPGSS TLLAMERAGD NSQSVYIPMS PGAHHFDSLG YPSTTLPVHR 500
GPSRGSEIQP PPVNRNLKPD RKAKPTPLDL RNNTVIDELP FKSPITKSWS 550
RANHTFNSSS SQYCRPISTQ SITSTDSGDS EENYVPMQNP VSASPVPSGT 600
NSPAPKKSTG SVDYLALDFQ PSSPSPHRKP STSSVTSDEK VDYVQVDKEK 650
TQALQNTMQE WTDVRQSSEP SKGAKL

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