DOK1 is a predicted scaffold protein, which is related to the following pathway(s).

CSK->FYN->GRB10
CSK->FYN->SHC1
CSK->SRC->GRB10
CSK->SRC->ITGB3
CSK->SRC->KIT
CSK->SRC->PIK3R1
CSK->SRC->PTPN6
CSK->SRC->SHC1
CSK->SRC->ABL1->CRKL


DOK1 is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
SHC1SYK->PRKCA->INSR->DOK1
PTPN6SYK->PRKCA->INSR->DOK1


The sequence of DOK1

Amino acids in red are phosphorylation sites determined by MS/MS

AEQVALSRTH VCGILREELF QGDAFHQSDT HIFIIMGASG DLAKKKIYPT 50
IWWLFRDGLL PENTFIVGYA RSRLTVADIR KQSEPFFKAT PEEKLKLEDF 100
FARNSYVAGQ YDDAASYQRL NSHMNALHLG SQANRLFYLA LPPTVYEAVT 150
KNIHESCMSQ IGWNRIIVEK PFGRDLQSSD RLSNHISSLF REDQIYRIDH 200
YLGKEMVQNL MVLRFANRIF GPIWNRDNIA CVILTFKEPF GTEGRGGYFD 250
EFGIIRDVMQ NHLLQMLCLV AMEKPASTNS DDVRDEKVKV LKCISEVQAN 300
NVVLGQYVGN PDGEGEATKG YLDDPTVPRG STTATFAAVV LYVENERWDG 350
VPFILRCGKA LNERKAEVRL QFHDVAGDIF HQQCKRNELV IRVQPNEAVY 400
TKMMTKKPGM FFNPEESELD LTYGNRYKNV KLPDAYERLI LDVFCGSQMH 450
FVRSDELREA WRIFTPLLHQ IELEKPKPIP YIYGSRGPTE ADELMKRVGF 500
QYEGTYKWVN PHKL

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